Reduced plasma GDF10 levels are positively associated with cholesterol impairment and childhood obesity
Abstract Childhood obesity is a global health concern affecting over 150 million children worldwide, with projections of a rise to 206 million by 2025. Understanding the mechanisms underlying this epidemic is crucial for developing effective interventions. In this study, we investigated circulating...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-01-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-51635-1 |
| _version_ | 1797349952343506944 |
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| author | Tamana R. Yousof Aurora Mejia-Benitez Katherine M. Morrison Richard C. Austin |
| author_facet | Tamana R. Yousof Aurora Mejia-Benitez Katherine M. Morrison Richard C. Austin |
| author_sort | Tamana R. Yousof |
| collection | DOAJ |
| description | Abstract Childhood obesity is a global health concern affecting over 150 million children worldwide, with projections of a rise to 206 million by 2025. Understanding the mechanisms underlying this epidemic is crucial for developing effective interventions. In this study, we investigated circulating levels of Growth Differentiation Factor 10 (GDF10), a novel regulator of adipogenesis. Previous studies report diminished circulating GDF10 levels contribute to obesity and hepatic steatosis in mice. To further understand the role of plasma GDF10 in childhood obesity, a prospective case–control study was conducted. Using an enzyme-linked immunosorbent assay, plasma GDF10 levels were measured in children aged 5–17 years of age with normal (n = 36) and increased (n = 56) body mass index (BMI). Subsequently, plasma GDF10 levels were compared to various cardio-metabolic parameters. Children with increased BMI exhibit significantly lower levels of plasma GDF10 compared to children with normal BMI (p < 0.05). This study not only supports previous mouse data but is the first to report that lower levels of GDF10 is associated with childhood obesity, providing an important human connection for the relevance of GDF10 in obesity. Furthermore, this study revealed a significant correlation between low plasma GDF10 levels and elevated LDL-cholesterol and total cholesterol levels dependent on BMI (95% CI, p < 0.05). This study supports the hypothesis that children with obesity display lower plasma levels of GDF10, which correlates with elevated cholesterol levels. These insights shed light on potential mechanisms contributing to childhood obesity and may lead to future therapeutic interventions targeting GDF10 to mitigate adverse effects of adipogenesis in cardiometabolic health. |
| first_indexed | 2024-03-08T12:37:48Z |
| format | Article |
| id | doaj.art-c6fa06429f994857add23c7d75eb36da |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-08T12:37:48Z |
| publishDate | 2024-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-c6fa06429f994857add23c7d75eb36da2024-01-21T12:20:38ZengNature PortfolioScientific Reports2045-23222024-01-011411710.1038/s41598-024-51635-1Reduced plasma GDF10 levels are positively associated with cholesterol impairment and childhood obesityTamana R. Yousof0Aurora Mejia-Benitez1Katherine M. Morrison2Richard C. Austin3Division of Nephrology, Department of Medicine, McMaster University and The Research Institute of St. Joe’s HamiltonDivision of Nephrology, Department of Medicine, McMaster University and The Research Institute of St. Joe’s HamiltonDepartment of Pediatrics, Centre for Metabolism, Obesity and Diabetes Research, McMaster UniversityDivision of Nephrology, Department of Medicine, McMaster University and The Research Institute of St. Joe’s HamiltonAbstract Childhood obesity is a global health concern affecting over 150 million children worldwide, with projections of a rise to 206 million by 2025. Understanding the mechanisms underlying this epidemic is crucial for developing effective interventions. In this study, we investigated circulating levels of Growth Differentiation Factor 10 (GDF10), a novel regulator of adipogenesis. Previous studies report diminished circulating GDF10 levels contribute to obesity and hepatic steatosis in mice. To further understand the role of plasma GDF10 in childhood obesity, a prospective case–control study was conducted. Using an enzyme-linked immunosorbent assay, plasma GDF10 levels were measured in children aged 5–17 years of age with normal (n = 36) and increased (n = 56) body mass index (BMI). Subsequently, plasma GDF10 levels were compared to various cardio-metabolic parameters. Children with increased BMI exhibit significantly lower levels of plasma GDF10 compared to children with normal BMI (p < 0.05). This study not only supports previous mouse data but is the first to report that lower levels of GDF10 is associated with childhood obesity, providing an important human connection for the relevance of GDF10 in obesity. Furthermore, this study revealed a significant correlation between low plasma GDF10 levels and elevated LDL-cholesterol and total cholesterol levels dependent on BMI (95% CI, p < 0.05). This study supports the hypothesis that children with obesity display lower plasma levels of GDF10, which correlates with elevated cholesterol levels. These insights shed light on potential mechanisms contributing to childhood obesity and may lead to future therapeutic interventions targeting GDF10 to mitigate adverse effects of adipogenesis in cardiometabolic health.https://doi.org/10.1038/s41598-024-51635-1 |
| spellingShingle | Tamana R. Yousof Aurora Mejia-Benitez Katherine M. Morrison Richard C. Austin Reduced plasma GDF10 levels are positively associated with cholesterol impairment and childhood obesity Scientific Reports |
| title | Reduced plasma GDF10 levels are positively associated with cholesterol impairment and childhood obesity |
| title_full | Reduced plasma GDF10 levels are positively associated with cholesterol impairment and childhood obesity |
| title_fullStr | Reduced plasma GDF10 levels are positively associated with cholesterol impairment and childhood obesity |
| title_full_unstemmed | Reduced plasma GDF10 levels are positively associated with cholesterol impairment and childhood obesity |
| title_short | Reduced plasma GDF10 levels are positively associated with cholesterol impairment and childhood obesity |
| title_sort | reduced plasma gdf10 levels are positively associated with cholesterol impairment and childhood obesity |
| url | https://doi.org/10.1038/s41598-024-51635-1 |
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