The Burkholderia Type VI Secretion System 5: Composition, Regulation and Role in Virulence
The soil saprophyte and Tier I select agent Burkholderia pseudomallei can cause rapidly fatal infections in humans and animals. The capability of switching to an intracellular life cycle during infection appears to be a decisive trait of B. pseudomallei for causing disease. B. pseudomallei harbors m...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-01-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fmicb.2018.03339/full |
| _version_ | 1819077739184914432 |
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| author | Jan Lennings T. Eoin West Sandra Schwarz |
| author_facet | Jan Lennings T. Eoin West Sandra Schwarz |
| author_sort | Jan Lennings |
| collection | DOAJ |
| description | The soil saprophyte and Tier I select agent Burkholderia pseudomallei can cause rapidly fatal infections in humans and animals. The capability of switching to an intracellular life cycle during infection appears to be a decisive trait of B. pseudomallei for causing disease. B. pseudomallei harbors multiple type VI secretion systems (T6SSs) orthologs of which are present in the surrogate organism Burkholderia thailandensis. Upon host cell entry and vacuolar escape into the cytoplasm, B. pseudomallei and B. thailandensis manipulate host cells by utilizing the T6SS-5 (also termed T6SS1) to form multinucleated giant cells for intercellular spread. Disruption of the T6SS-5 in B. thailandensis causes a drastic attenuation of virulence in wildtype but not in mice lacking the central innate immune adapter protein MyD88. This result suggests that the T6SS-5 is deployed by the bacteria to overcome innate immune responses. However, important questions in this field remain unsolved including the mechanism underlying T6SS-5 activity and its physiological role during infection. In this review, we summarize the current knowledge on the components and regulation of the T6SS-5 as well as its role in virulence in mammalian hosts. |
| first_indexed | 2024-12-21T19:01:59Z |
| format | Article |
| id | doaj.art-c6fa3606501943b28a37bdfe65433134 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-21T19:01:59Z |
| publishDate | 2019-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-c6fa3606501943b28a37bdfe654331342022-12-21T18:53:28ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2019-01-01910.3389/fmicb.2018.03339436682The Burkholderia Type VI Secretion System 5: Composition, Regulation and Role in VirulenceJan Lennings0T. Eoin West1Sandra Schwarz2Interfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, Tübingen, GermanyDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Washington, Seattle, WA, United StatesInterfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, Tübingen, GermanyThe soil saprophyte and Tier I select agent Burkholderia pseudomallei can cause rapidly fatal infections in humans and animals. The capability of switching to an intracellular life cycle during infection appears to be a decisive trait of B. pseudomallei for causing disease. B. pseudomallei harbors multiple type VI secretion systems (T6SSs) orthologs of which are present in the surrogate organism Burkholderia thailandensis. Upon host cell entry and vacuolar escape into the cytoplasm, B. pseudomallei and B. thailandensis manipulate host cells by utilizing the T6SS-5 (also termed T6SS1) to form multinucleated giant cells for intercellular spread. Disruption of the T6SS-5 in B. thailandensis causes a drastic attenuation of virulence in wildtype but not in mice lacking the central innate immune adapter protein MyD88. This result suggests that the T6SS-5 is deployed by the bacteria to overcome innate immune responses. However, important questions in this field remain unsolved including the mechanism underlying T6SS-5 activity and its physiological role during infection. In this review, we summarize the current knowledge on the components and regulation of the T6SS-5 as well as its role in virulence in mammalian hosts.https://www.frontiersin.org/article/10.3389/fmicb.2018.03339/fullB. pseudomalleitype VI secretion systemintracellular life cyclemultinucleated giant cell formationvirulence |
| spellingShingle | Jan Lennings T. Eoin West Sandra Schwarz The Burkholderia Type VI Secretion System 5: Composition, Regulation and Role in Virulence Frontiers in Microbiology B. pseudomallei type VI secretion system intracellular life cycle multinucleated giant cell formation virulence |
| title | The Burkholderia Type VI Secretion System 5: Composition, Regulation and Role in Virulence |
| title_full | The Burkholderia Type VI Secretion System 5: Composition, Regulation and Role in Virulence |
| title_fullStr | The Burkholderia Type VI Secretion System 5: Composition, Regulation and Role in Virulence |
| title_full_unstemmed | The Burkholderia Type VI Secretion System 5: Composition, Regulation and Role in Virulence |
| title_short | The Burkholderia Type VI Secretion System 5: Composition, Regulation and Role in Virulence |
| title_sort | burkholderia type vi secretion system 5 composition regulation and role in virulence |
| topic | B. pseudomallei type VI secretion system intracellular life cycle multinucleated giant cell formation virulence |
| url | https://www.frontiersin.org/article/10.3389/fmicb.2018.03339/full |
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