The Role of Trace Elements and Minerals in Osteoporosis: A Review of Epidemiological and Laboratory Findings
The objective of the present study was to review recent epidemiological and clinical data on the association between selected minerals and trace elements and osteoporosis, as well as to discuss the molecular mechanisms underlying these associations. We have performed a search in the PubMed-Medline a...
| Những tác giả chính: | , , , , , , , , , |
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| Định dạng: | Bài viết |
| Ngôn ngữ: | English |
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MDPI AG
2023-06-01
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| Loạt: | Biomolecules |
| Những chủ đề: | |
| Truy cập trực tuyến: | https://www.mdpi.com/2218-273X/13/6/1006 |
| _version_ | 1827738277275238400 |
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| author | Anatoly V. Skalny Michael Aschner Ekaterina V. Silina Victor A. Stupin Oleg N. Zaitsev Tatiana I. Sotnikova Serafima Ia. Tazina Feng Zhang Xiong Guo Alexey A. Tinkov |
| author_facet | Anatoly V. Skalny Michael Aschner Ekaterina V. Silina Victor A. Stupin Oleg N. Zaitsev Tatiana I. Sotnikova Serafima Ia. Tazina Feng Zhang Xiong Guo Alexey A. Tinkov |
| author_sort | Anatoly V. Skalny |
| collection | DOAJ |
| description | The objective of the present study was to review recent epidemiological and clinical data on the association between selected minerals and trace elements and osteoporosis, as well as to discuss the molecular mechanisms underlying these associations. We have performed a search in the PubMed-Medline and Google Scholar databases using the MeSH terms “osteoporosis”, “osteogenesis”, “osteoblast”, “osteoclast”, and “osteocyte” in association with the names of particular trace elements and minerals through 21 March 2023. The data demonstrate that physiological and nutritional levels of trace elements and minerals promote osteogenic differentiation through the up-regulation of BMP-2 and Wnt/β-catenin signaling, as well as other pathways. miRNA and epigenetic effects were also involved in the regulation of the osteogenic effects of trace minerals. The antiresorptive effect of trace elements and minerals was associated with the inhibition of osteoclastogenesis. At the same time, the effect of trace elements and minerals on bone health appeared to be dose-dependent with low doses promoting an osteogenic effect, whereas high doses exerted opposite effects which promoted bone resorption and impaired bone formation. Concomitant with the results of the laboratory studies, several clinical trials and epidemiological studies demonstrated that supplementation with Zn, Mg, F, and Sr may improve bone quality, thus inducing antiosteoporotic effects. |
| first_indexed | 2024-03-11T02:42:09Z |
| format | Article |
| id | doaj.art-c6fc30660870450487ef77ceec949aae |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-11T02:42:09Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-c6fc30660870450487ef77ceec949aae2023-11-18T09:31:50ZengMDPI AGBiomolecules2218-273X2023-06-01136100610.3390/biom13061006The Role of Trace Elements and Minerals in Osteoporosis: A Review of Epidemiological and Laboratory FindingsAnatoly V. Skalny0Michael Aschner1Ekaterina V. Silina2Victor A. Stupin3Oleg N. Zaitsev4Tatiana I. Sotnikova5Serafima Ia. Tazina6Feng Zhang7Xiong Guo8Alexey A. Tinkov9Laboratory of Ecobiomonitoring and Quality Control, Yaroslavl State University, 150003 Yaroslavl, RussiaDepartment of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USACenter of Bioelementology and Human Ecology, Institute of Biodesign and Modeling of Complex Systems, Department of Therapy of the Institute of Postgraduate Education, IM Sechenov First Moscow State Medical University (Sechenov University), 119435 Moscow, RussiaDepartment of Hospital Surgery No. 1, Pirogov Russian National Research Medical University, 117997 Moscow, RussiaDepartment of Physical Education, Yaroslavl State Technical University, 150023 Yaroslavl, RussiaCenter of Bioelementology and Human Ecology, Institute of Biodesign and Modeling of Complex Systems, Department of Therapy of the Institute of Postgraduate Education, IM Sechenov First Moscow State Medical University (Sechenov University), 119435 Moscow, RussiaCenter of Bioelementology and Human Ecology, Institute of Biodesign and Modeling of Complex Systems, Department of Therapy of the Institute of Postgraduate Education, IM Sechenov First Moscow State Medical University (Sechenov University), 119435 Moscow, RussiaKey Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Health Science Center, School of Public Health, Xi’an Jiaotong University, Xi’an 710061, ChinaKey Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Health Science Center, School of Public Health, Xi’an Jiaotong University, Xi’an 710061, ChinaLaboratory of Ecobiomonitoring and Quality Control, Yaroslavl State University, 150003 Yaroslavl, RussiaThe objective of the present study was to review recent epidemiological and clinical data on the association between selected minerals and trace elements and osteoporosis, as well as to discuss the molecular mechanisms underlying these associations. We have performed a search in the PubMed-Medline and Google Scholar databases using the MeSH terms “osteoporosis”, “osteogenesis”, “osteoblast”, “osteoclast”, and “osteocyte” in association with the names of particular trace elements and minerals through 21 March 2023. The data demonstrate that physiological and nutritional levels of trace elements and minerals promote osteogenic differentiation through the up-regulation of BMP-2 and Wnt/β-catenin signaling, as well as other pathways. miRNA and epigenetic effects were also involved in the regulation of the osteogenic effects of trace minerals. The antiresorptive effect of trace elements and minerals was associated with the inhibition of osteoclastogenesis. At the same time, the effect of trace elements and minerals on bone health appeared to be dose-dependent with low doses promoting an osteogenic effect, whereas high doses exerted opposite effects which promoted bone resorption and impaired bone formation. Concomitant with the results of the laboratory studies, several clinical trials and epidemiological studies demonstrated that supplementation with Zn, Mg, F, and Sr may improve bone quality, thus inducing antiosteoporotic effects.https://www.mdpi.com/2218-273X/13/6/1006osteoporosistrace elementsbone mineral densitymineralsbone resorptionselenium |
| spellingShingle | Anatoly V. Skalny Michael Aschner Ekaterina V. Silina Victor A. Stupin Oleg N. Zaitsev Tatiana I. Sotnikova Serafima Ia. Tazina Feng Zhang Xiong Guo Alexey A. Tinkov The Role of Trace Elements and Minerals in Osteoporosis: A Review of Epidemiological and Laboratory Findings Biomolecules osteoporosis trace elements bone mineral density minerals bone resorption selenium |
| title | The Role of Trace Elements and Minerals in Osteoporosis: A Review of Epidemiological and Laboratory Findings |
| title_full | The Role of Trace Elements and Minerals in Osteoporosis: A Review of Epidemiological and Laboratory Findings |
| title_fullStr | The Role of Trace Elements and Minerals in Osteoporosis: A Review of Epidemiological and Laboratory Findings |
| title_full_unstemmed | The Role of Trace Elements and Minerals in Osteoporosis: A Review of Epidemiological and Laboratory Findings |
| title_short | The Role of Trace Elements and Minerals in Osteoporosis: A Review of Epidemiological and Laboratory Findings |
| title_sort | role of trace elements and minerals in osteoporosis a review of epidemiological and laboratory findings |
| topic | osteoporosis trace elements bone mineral density minerals bone resorption selenium |
| url | https://www.mdpi.com/2218-273X/13/6/1006 |
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