Streptozotocin induces renal proximal tubular injury through p53 signaling activation

Streptozotocin induces renal proximal tubular injury through p53 signaling activation

Abstract Streptozotocin (STZ), an anti-cancer drug that is primarily used to treat neuroendocrine tumors (NETs) in clinical settings, is incorporated into pancreatic β-cells or proximal tubular epithelial cells through the glucose transporter, GLUT2. However, its cytotoxic effects on kidney cells ha...

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Bibliographic Details
Main Authors: Kunihiro Nakai, Minato Umehara, Atsushi Minamida, Hiroko Yamauchi-Sawada, Yasuto Sunahara, Yayoi Matoba, Natsuko Okuno-Ozeki, Itaru Nakamura, Tomohiro Nakata, Aya Yagi-Tomita, Noriko Uehara-Watanabe, Tomoharu Ida, Noriyuki Yamashita, Michitsugu Kamezaki, Yuhei Kirita, Eiichi Konishi, Hiroaki Yasuda, Satoaki Matoba, Keiichi Tamagaki, Tetsuro Kusaba
Format: Article
Language:English
Published: Nature Portfolio 2023-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-35850-w

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