Small-vessel disease in the brain
Cerebral small-vessels are generally located in the brain at branch points from major cerebral blood vessels and perfuse subcortical structures such as the white matter tracts, basal ganglia, thalamus, and pons. Cerebral small-vessel disease (CSVD) can lead to several different clinical manifestatio...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-03-01
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| Series: | American Heart Journal Plus |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666602223000290 |
| _version_ | 1811154351659417600 |
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| author | Amita Singh Gabriel Bonnell Justin De Prey Natalie Buchwald Kyrillos Eskander Keith J. Kincaid Christina A. Wilson |
| author_facet | Amita Singh Gabriel Bonnell Justin De Prey Natalie Buchwald Kyrillos Eskander Keith J. Kincaid Christina A. Wilson |
| author_sort | Amita Singh |
| collection | DOAJ |
| description | Cerebral small-vessels are generally located in the brain at branch points from major cerebral blood vessels and perfuse subcortical structures such as the white matter tracts, basal ganglia, thalamus, and pons. Cerebral small-vessel disease (CSVD) can lead to several different clinical manifestations including ischemic lacunar stroke, intracerebral hemorrhage, and vascular dementia. Risk factors for CSVD overlap with conventional vascular risk factors including hypertension, diabetes mellitus, and hypercholesterolemia, as well as genetic causes. As in cardiovascular disease, treatment of CSVD involves both primary and secondary prevention. Aspirin has not been established as a primary prevention strategy for CSVD among the general population; however, long-term antiplatelet therapy with aspirin alone continues to be the mainstay of secondary stroke prevention for non-cardioembolic ischemic stroke and high-risk TIA. |
| first_indexed | 2024-04-10T04:15:22Z |
| format | Article |
| id | doaj.art-c6fcf54c77d44b68b7bb5ec21a59d508 |
| institution | Directory Open Access Journal |
| issn | 2666-6022 |
| language | English |
| last_indexed | 2024-04-10T04:15:22Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | American Heart Journal Plus |
| spelling | doaj.art-c6fcf54c77d44b68b7bb5ec21a59d5082023-03-12T04:22:22ZengElsevierAmerican Heart Journal Plus2666-60222023-03-0127100277Small-vessel disease in the brainAmita Singh0Gabriel Bonnell1Justin De Prey2Natalie Buchwald3Kyrillos Eskander4Keith J. Kincaid5Christina A. Wilson6Department of Neurology, University of Florida, Gainesville, FL, United States of AmericaDepartment of Neurology, University of Florida, Gainesville, FL, United States of AmericaDepartment of Neurology, University of Florida, Gainesville, FL, United States of AmericaDepartment of Neurology, University of Florida, Gainesville, FL, United States of AmericaDepartment of Neurology, University of Florida, Gainesville, FL, United States of AmericaDepartment of Neurology, University of Florida, Gainesville, FL, United States of AmericaCorresponding author at: Department of Neurology, University of Florida, 1149 Newell Dr., PO Box 100236, Gainesville, FL 32610, United States of America.; Department of Neurology, University of Florida, Gainesville, FL, United States of AmericaCerebral small-vessels are generally located in the brain at branch points from major cerebral blood vessels and perfuse subcortical structures such as the white matter tracts, basal ganglia, thalamus, and pons. Cerebral small-vessel disease (CSVD) can lead to several different clinical manifestations including ischemic lacunar stroke, intracerebral hemorrhage, and vascular dementia. Risk factors for CSVD overlap with conventional vascular risk factors including hypertension, diabetes mellitus, and hypercholesterolemia, as well as genetic causes. As in cardiovascular disease, treatment of CSVD involves both primary and secondary prevention. Aspirin has not been established as a primary prevention strategy for CSVD among the general population; however, long-term antiplatelet therapy with aspirin alone continues to be the mainstay of secondary stroke prevention for non-cardioembolic ischemic stroke and high-risk TIA.http://www.sciencedirect.com/science/article/pii/S2666602223000290Small-vessel diseaseBrainIschemic strokeHemorrhageVascular dementia |
| spellingShingle | Amita Singh Gabriel Bonnell Justin De Prey Natalie Buchwald Kyrillos Eskander Keith J. Kincaid Christina A. Wilson Small-vessel disease in the brain American Heart Journal Plus Small-vessel disease Brain Ischemic stroke Hemorrhage Vascular dementia |
| title | Small-vessel disease in the brain |
| title_full | Small-vessel disease in the brain |
| title_fullStr | Small-vessel disease in the brain |
| title_full_unstemmed | Small-vessel disease in the brain |
| title_short | Small-vessel disease in the brain |
| title_sort | small vessel disease in the brain |
| topic | Small-vessel disease Brain Ischemic stroke Hemorrhage Vascular dementia |
| url | http://www.sciencedirect.com/science/article/pii/S2666602223000290 |
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