Altered Conformational Landscape upon Sensing Guanine Nucleotides in a Disease Mutant of Elongation Factor-like 1 (EFL1) GTPase

Altered Conformational Landscape upon Sensing Guanine Nucleotides in a Disease Mutant of Elongation Factor-like 1 (EFL1) GTPase

The final maturation step of the 60S ribosomal subunit requires the release of eukaryotic translation initiation factor 6 (human eIF6, yeast Tif6) to enter the pool of mature ribosomes capable of engaging in translation. This process is mediated by the concerted action of the Elongation Factor-like...

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Bibliographic Details
Main Authors: Jesús Pérez-Juárez, Juana Virginia Tapia-Vieyra, Gabriel Gutiérrez-Magdaleno, Nuria Sánchez-Puig
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Biomolecules
Subjects:
conformational change
EFL1
guanine nucleotides
ITC
magnesium ions
SBDS
Online Access:https://www.mdpi.com/2218-273X/12/8/1141

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