Oligodendrocyte lineage is severely affected in human alcohol-exposed foetuses

Oligodendrocyte lineage is severely affected in human alcohol-exposed foetuses

Abstract Prenatal alcohol exposure is a major cause of neurobehavioral disabilities. MRI studies in humans have shown that alcohol is associated with white matter microstructural anomalies but these studies focused on myelin abnormalities only after birth. Only one of these studies evaluated oligode...

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Bibliographic Details
Main Authors: Florent Marguet, Mélanie Brosolo, Gaëlle Friocourt, Fanny Sauvestre, Pascale Marcorelles, Céline Lesueur, Stéphane Marret, Bruno J. Gonzalez, Annie Laquerrière
Format: Article
Language:English
Published: BMC 2022-05-01
Series:Acta Neuropathologica Communications
Subjects:
Oligodendrocyte precursors
PDGFR-α
Olig2
Myelination defects
Human foetal brain
Foetal alcohol syndrome
Online Access:https://doi.org/10.1186/s40478-022-01378-9

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