Functional Classification and Interaction Selectivity Landscape of the Human SH3 Domain Superfamily

Functional Classification and Interaction Selectivity Landscape of the Human SH3 Domain Superfamily

SRC homology 3 (SH3) domains are critical interaction modules that orchestrate the assembly of protein complexes involved in diverse biological processes. They facilitate transient protein–protein interactions by selectively interacting with proline-rich motifs (PRMs). A database search revealed 298...

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Bibliographic Details
Main Authors: Neda S. Kazemein Jasemi, Mehrnaz Mehrabipour, Eva Magdalena Estirado, Luc Brunsveld, Radovan Dvorsky, Mohammad R. Ahmadian
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Cells
Subjects:
ARHGAP12
GRB2
NCK1
proline-rich motifs
protein–protein interaction
SH3 domain
Online Access:https://www.mdpi.com/2073-4409/13/2/195

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