Occurrence and severity of myasthenic crisis in an unselected Turkish cohort of patients with myasthenia gravis
Myasthenia gravis (MG) is a disorder of the neuromuscular junction that can deteriorate into myasthenic crisis, involving weakness of bulbar and respiratory muscles. In this study, we describe the clinical manifestations of myasthenic crisis, identify risk factors, and examine treatments and outcome...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-07-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1201451/full |
| _version_ | 1797780783165865984 |
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| author | Selen Ozyurt Kose Ezgi Nazli Kemal Tutkavul Nils Erik Gilhus Nils Erik Gilhus |
| author_facet | Selen Ozyurt Kose Ezgi Nazli Kemal Tutkavul Nils Erik Gilhus Nils Erik Gilhus |
| author_sort | Selen Ozyurt Kose |
| collection | DOAJ |
| description | Myasthenia gravis (MG) is a disorder of the neuromuscular junction that can deteriorate into myasthenic crisis, involving weakness of bulbar and respiratory muscles. In this study, we describe the clinical manifestations of myasthenic crisis, identify risk factors, and examine treatments and outcomes. All 95 patients with generalized MG treated at our center during the last 10 years were included in this retrospective study. We collected data from the patients' records, including clinical follow-ups, muscle antibodies, thymic status, and treatments. The characteristics of patients who did and did not experience myasthenic crisis were compared. Features of all myasthenic crises were also assessed. Twelve patients (13%) developed myasthenic crisis during the observation period. Men were more often affected at older ages. Seven patients experienced multiple myasthenic crises. Thymoma increased the risk of a crisis, whereas thymic hyperplasia decreased the risk. Myasthenic crises were more common in the summer months. No patients died during a myasthenic crisis. Risk factors for myasthenic crisis were thymoma, older age, MuSK antibodies, and previous crises. Individualized and active immunosuppressive treatment and optimal intensive care during crises provide a good outcome for patients with generalized MG. |
| first_indexed | 2024-03-12T23:48:44Z |
| format | Article |
| id | doaj.art-c70041f17ce94be3a9d88fe601029fc2 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-03-12T23:48:44Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-c70041f17ce94be3a9d88fe601029fc22023-07-14T02:11:20ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-07-011410.3389/fneur.2023.12014511201451Occurrence and severity of myasthenic crisis in an unselected Turkish cohort of patients with myasthenia gravisSelen Ozyurt Kose0Ezgi Nazli1Kemal Tutkavul2Nils Erik Gilhus3Nils Erik Gilhus4Department of Clinical Neurophysiology, Marmara University Pendik Teaching and Research Hospital, Istanbul, TurkeyDepartment of Neurology, Health Sciences University Haydarpasa Numune Teaching and Research Hospital, Istanbul, TurkeyDepartment of Neurology, Health Sciences University Haydarpasa Numune Teaching and Research Hospital, Istanbul, TurkeyDepartment of Neurology, Haukeland University Hospital, Bergen, NorwayDepartment of Clinical Medicine, University of Bergen, Bergen, NorwayMyasthenia gravis (MG) is a disorder of the neuromuscular junction that can deteriorate into myasthenic crisis, involving weakness of bulbar and respiratory muscles. In this study, we describe the clinical manifestations of myasthenic crisis, identify risk factors, and examine treatments and outcomes. All 95 patients with generalized MG treated at our center during the last 10 years were included in this retrospective study. We collected data from the patients' records, including clinical follow-ups, muscle antibodies, thymic status, and treatments. The characteristics of patients who did and did not experience myasthenic crisis were compared. Features of all myasthenic crises were also assessed. Twelve patients (13%) developed myasthenic crisis during the observation period. Men were more often affected at older ages. Seven patients experienced multiple myasthenic crises. Thymoma increased the risk of a crisis, whereas thymic hyperplasia decreased the risk. Myasthenic crises were more common in the summer months. No patients died during a myasthenic crisis. Risk factors for myasthenic crisis were thymoma, older age, MuSK antibodies, and previous crises. Individualized and active immunosuppressive treatment and optimal intensive care during crises provide a good outcome for patients with generalized MG.https://www.frontiersin.org/articles/10.3389/fneur.2023.1201451/fullmyasthenia gravismyasthenic crisisventilation supportprognosistreatment |
| spellingShingle | Selen Ozyurt Kose Ezgi Nazli Kemal Tutkavul Nils Erik Gilhus Nils Erik Gilhus Occurrence and severity of myasthenic crisis in an unselected Turkish cohort of patients with myasthenia gravis Frontiers in Neurology myasthenia gravis myasthenic crisis ventilation support prognosis treatment |
| title | Occurrence and severity of myasthenic crisis in an unselected Turkish cohort of patients with myasthenia gravis |
| title_full | Occurrence and severity of myasthenic crisis in an unselected Turkish cohort of patients with myasthenia gravis |
| title_fullStr | Occurrence and severity of myasthenic crisis in an unselected Turkish cohort of patients with myasthenia gravis |
| title_full_unstemmed | Occurrence and severity of myasthenic crisis in an unselected Turkish cohort of patients with myasthenia gravis |
| title_short | Occurrence and severity of myasthenic crisis in an unselected Turkish cohort of patients with myasthenia gravis |
| title_sort | occurrence and severity of myasthenic crisis in an unselected turkish cohort of patients with myasthenia gravis |
| topic | myasthenia gravis myasthenic crisis ventilation support prognosis treatment |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1201451/full |
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