PLGA-microspheres-carried circGMCL1 protects against Crohn’s colitis through alleviating NLRP3 inflammasome-induced pyroptosis by promoting autophagy

PLGA-microspheres-carried circGMCL1 protects against Crohn’s colitis through alleviating NLRP3 inflammasome-induced pyroptosis by promoting autophagy

Abstract This study aimed to at explore exploring the biological functions of dysregulated circRNA in Crohn’s disease (CD) pathogenesis, with the overarching goal of and providing potential novel therapeutic targets. CircRNA microarray and quantitative real time-polymerase chain reaction (qRT-PCR) a...

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Bibliographic Details
Main Authors: Jie Zhao, Ye Sun, Haojun Yang, Jun Qian, Yan Zhou, Yu Gong, Yi Dai, Yuwen Jiao, Weiming Zhu, Honggang Wang, Zhiliang Lin, Liming Tang
Format: Article
Language:English
Published: Nature Publishing Group 2022-09-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-05226-5

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