Anal Canal Melanoma: Challenging the Odds
Introduction: Anal canal melanoma is a rare form of both anal cancer and skin melanoma, representing 1% of all anal cancers. Diagnosis is often made at an advanced disease stage. Because of late diagnosis and aggressive clinical course, anal canal melanoma has a very poor prognosis. Case Presentatio...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Karger Publishers
2024-02-01
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| Series: | Case Reports in Oncology |
| Subjects: | |
| Online Access: | https://beta.karger.com/Article/FullText/535956 |
| _version_ | 1797270032789536768 |
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| author | Sara Magno Hugo Nunes |
| author_facet | Sara Magno Hugo Nunes |
| author_sort | Sara Magno |
| collection | DOAJ |
| description | Introduction: Anal canal melanoma is a rare form of both anal cancer and skin melanoma, representing 1% of all anal cancers. Diagnosis is often made at an advanced disease stage. Because of late diagnosis and aggressive clinical course, anal canal melanoma has a very poor prognosis. Case Presentation: We present the case of a 61-year-old female with anal canal melanoma and lung, liver, pelvic and central nervous system (CNS) metastasis, BRAF V600E mutated. Combined BRAF/MEK inhibition and CNS radiation therapy were able to achieve excellent local and distant disease control. Conclusion: Anal canal melanoma is a rare and aggressive form of melanoma. Multidisciplinary management in experienced centers is mandatory for good clinical outcomes. |
| first_indexed | 2024-03-07T19:38:59Z |
| format | Article |
| id | doaj.art-c705b47c073443269e467557b8df99f0 |
| institution | Directory Open Access Journal |
| issn | 1662-6575 |
| language | English |
| last_indexed | 2024-04-25T01:57:49Z |
| publishDate | 2024-02-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Oncology |
| spelling | doaj.art-c705b47c073443269e467557b8df99f02024-03-07T15:41:15ZengKarger PublishersCase Reports in Oncology1662-65752024-02-0117122523110.1159/000535956535956Anal Canal Melanoma: Challenging the OddsSara Magno0Hugo Nunes1Medical Oncology, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, PortugalMedical Oncology, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, PortugalIntroduction: Anal canal melanoma is a rare form of both anal cancer and skin melanoma, representing 1% of all anal cancers. Diagnosis is often made at an advanced disease stage. Because of late diagnosis and aggressive clinical course, anal canal melanoma has a very poor prognosis. Case Presentation: We present the case of a 61-year-old female with anal canal melanoma and lung, liver, pelvic and central nervous system (CNS) metastasis, BRAF V600E mutated. Combined BRAF/MEK inhibition and CNS radiation therapy were able to achieve excellent local and distant disease control. Conclusion: Anal canal melanoma is a rare and aggressive form of melanoma. Multidisciplinary management in experienced centers is mandatory for good clinical outcomes.https://beta.karger.com/Article/FullText/535956anal canalmelanomabraf |
| spellingShingle | Sara Magno Hugo Nunes Anal Canal Melanoma: Challenging the Odds Case Reports in Oncology anal canal melanoma braf |
| title | Anal Canal Melanoma: Challenging the Odds |
| title_full | Anal Canal Melanoma: Challenging the Odds |
| title_fullStr | Anal Canal Melanoma: Challenging the Odds |
| title_full_unstemmed | Anal Canal Melanoma: Challenging the Odds |
| title_short | Anal Canal Melanoma: Challenging the Odds |
| title_sort | anal canal melanoma challenging the odds |
| topic | anal canal melanoma braf |
| url | https://beta.karger.com/Article/FullText/535956 |
| work_keys_str_mv | AT saramagno analcanalmelanomachallengingtheodds AT hugonunes analcanalmelanomachallengingtheodds |