Antitumor Activities of Interleukin-12 in Melanoma
Melanoma is the most common and serious malignant tumor among skin cancers. Although more and more studies have revolutionized the systematic treatment of advanced melanoma in recent years, access to innovative drugs for melanoma is still greatly restricted in many countries. IL-12 produced mainly b...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/14/22/5592 |
| _version_ | 1797465732940824576 |
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| author | Wei Gao Jun Pan Jianping Pan |
| author_facet | Wei Gao Jun Pan Jianping Pan |
| author_sort | Wei Gao |
| collection | DOAJ |
| description | Melanoma is the most common and serious malignant tumor among skin cancers. Although more and more studies have revolutionized the systematic treatment of advanced melanoma in recent years, access to innovative drugs for melanoma is still greatly restricted in many countries. IL-12 produced mainly by antigen-presenting cells regulates the immune response and affects the differentiation of T cells in the process of antigen presentation. However, the dose-limited toxicity of IL-12 limits its clinical application. The present review summarizes the basic biological functions and toxicity of IL-12 in the treatment of melanoma and discusses the clinical application of IL-12, especially the combination of IL-12 with immune checkpoint inhibitors, cytokines and other therapeutic drugs. We also summarize several promising technological approaches such as carriers that have been developed to improve the pharmacokinetics, efficacy and safety of IL-12 or IL-12 encoding plasmid application. |
| first_indexed | 2024-03-09T18:26:45Z |
| format | Article |
| id | doaj.art-c705c43ac1054b4a8281b2bb2e6997f2 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T18:26:45Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-c705c43ac1054b4a8281b2bb2e6997f22023-11-24T07:53:36ZengMDPI AGCancers2072-66942022-11-011422559210.3390/cancers14225592Antitumor Activities of Interleukin-12 in MelanomaWei Gao0Jun Pan1Jianping Pan2Institute of Translational Medicine, Zhejiang University City College, Hangzhou 310015, ChinaInstitute of Cancer, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, ChinaInstitute of Translational Medicine, Zhejiang University City College, Hangzhou 310015, ChinaMelanoma is the most common and serious malignant tumor among skin cancers. Although more and more studies have revolutionized the systematic treatment of advanced melanoma in recent years, access to innovative drugs for melanoma is still greatly restricted in many countries. IL-12 produced mainly by antigen-presenting cells regulates the immune response and affects the differentiation of T cells in the process of antigen presentation. However, the dose-limited toxicity of IL-12 limits its clinical application. The present review summarizes the basic biological functions and toxicity of IL-12 in the treatment of melanoma and discusses the clinical application of IL-12, especially the combination of IL-12 with immune checkpoint inhibitors, cytokines and other therapeutic drugs. We also summarize several promising technological approaches such as carriers that have been developed to improve the pharmacokinetics, efficacy and safety of IL-12 or IL-12 encoding plasmid application.https://www.mdpi.com/2072-6694/14/22/5592melanomaIL-12cancer therapy |
| spellingShingle | Wei Gao Jun Pan Jianping Pan Antitumor Activities of Interleukin-12 in Melanoma Cancers melanoma IL-12 cancer therapy |
| title | Antitumor Activities of Interleukin-12 in Melanoma |
| title_full | Antitumor Activities of Interleukin-12 in Melanoma |
| title_fullStr | Antitumor Activities of Interleukin-12 in Melanoma |
| title_full_unstemmed | Antitumor Activities of Interleukin-12 in Melanoma |
| title_short | Antitumor Activities of Interleukin-12 in Melanoma |
| title_sort | antitumor activities of interleukin 12 in melanoma |
| topic | melanoma IL-12 cancer therapy |
| url | https://www.mdpi.com/2072-6694/14/22/5592 |
| work_keys_str_mv | AT weigao antitumoractivitiesofinterleukin12inmelanoma AT junpan antitumoractivitiesofinterleukin12inmelanoma AT jianpingpan antitumoractivitiesofinterleukin12inmelanoma |