Molecular Pathogenesis of Myeloproliferative Neoplasms: From Molecular Landscape to Therapeutic Implications

Molecular Pathogenesis of Myeloproliferative Neoplasms: From Molecular Landscape to Therapeutic Implications

Despite distinct clinical entities, the myeloproliferative neoplasms (MPN) share morphological similarities, propensity to thrombotic events and leukemic evolution, and a complex molecular pathogenesis. Well-known driver mutations, <i>JAK2</i>, <i>MPL</i> and <i>CALR<...

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Bibliographic Details
Main Authors: Erika Morsia, Elena Torre, Antonella Poloni, Attilio Olivieri, Serena Rupoli
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:International Journal of Molecular Sciences
Subjects:
myeloproliferative neoplasms
JAK/STAT pathway
additional mutations
Online Access:https://www.mdpi.com/1422-0067/23/9/4573

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