'Metal elements and pesticides as risk factors for Parkinson's disease - A review'
Essential metals including iron (Fe) and manganese (Mn) with known physiological functions in human body play an important role in cell homeostasis. Excessive exposure to these essential as well as non-essential metals including mercury (Hg) and Aluminum (Al) may contribute to pathological condition...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2021-01-01
|
| Series: | Toxicology Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214750021000500 |
| _version_ | 1818352712171913216 |
|---|---|
| author | Inam Ullah Longhe Zhao Yang Hai Muhammad Fahim Dhafer Alwayli Xin Wang Hongyu Li |
| author_facet | Inam Ullah Longhe Zhao Yang Hai Muhammad Fahim Dhafer Alwayli Xin Wang Hongyu Li |
| author_sort | Inam Ullah |
| collection | DOAJ |
| description | Essential metals including iron (Fe) and manganese (Mn) with known physiological functions in human body play an important role in cell homeostasis. Excessive exposure to these essential as well as non-essential metals including mercury (Hg) and Aluminum (Al) may contribute to pathological conditions, including PD. Each metal could be toxic through specific pathways. Epidemiological evidences from occupational and ecological studies besides various in vivo and in vitro studies have revealed the possible pathogenic role and neurotoxicity of different metals. Pesticides are substances that aim to mitigate the harm done by pests to plants and crops, and are extensively used to boost agricultural production. This review provides an outline of our current knowledge on the possible association between metals and PD. We have discussed the potential association between these two, furthermore the chemical properties, biological and toxicological aspects as well as possible mechanisms of Fe, Mn, Cu, Zn, Al, Ca, Pb, Hg and Zn in PD pathogenesis. In addition, we review recent evidence on deregulated microRNAs upon pesticide exposure and possible role of deregulated miRNA and pesticides to PD pathogenesis. |
| first_indexed | 2024-12-13T18:57:59Z |
| format | Article |
| id | doaj.art-c708954482bd4960ac0894d636f42bfd |
| institution | Directory Open Access Journal |
| issn | 2214-7500 |
| language | English |
| last_indexed | 2024-12-13T18:57:59Z |
| publishDate | 2021-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Toxicology Reports |
| spelling | doaj.art-c708954482bd4960ac0894d636f42bfd2022-12-21T23:34:46ZengElsevierToxicology Reports2214-75002021-01-018607616'Metal elements and pesticides as risk factors for Parkinson's disease - A review'Inam Ullah0Longhe Zhao1Yang Hai2Muhammad Fahim3Dhafer Alwayli4Xin Wang5Hongyu Li6School of Life Sciences, Lanzhou University, ChinaSchool of Pharmacy, Lanzhou University, ChinaSchool of Pharmacy, Lanzhou University, ChinaSchool of Life Sciences, Lanzhou University, ChinaSchool of Life Sciences, Lanzhou University, ChinaSchool of Pharmacy, Lanzhou University, China; Corresponding authors at: School of Pharmacy, Lanzhou university, China.School of Life Sciences, Lanzhou University, China; School of Pharmacy, Lanzhou University, China; Corresponding authors at: School of Pharmacy, Lanzhou university, China.Essential metals including iron (Fe) and manganese (Mn) with known physiological functions in human body play an important role in cell homeostasis. Excessive exposure to these essential as well as non-essential metals including mercury (Hg) and Aluminum (Al) may contribute to pathological conditions, including PD. Each metal could be toxic through specific pathways. Epidemiological evidences from occupational and ecological studies besides various in vivo and in vitro studies have revealed the possible pathogenic role and neurotoxicity of different metals. Pesticides are substances that aim to mitigate the harm done by pests to plants and crops, and are extensively used to boost agricultural production. This review provides an outline of our current knowledge on the possible association between metals and PD. We have discussed the potential association between these two, furthermore the chemical properties, biological and toxicological aspects as well as possible mechanisms of Fe, Mn, Cu, Zn, Al, Ca, Pb, Hg and Zn in PD pathogenesis. In addition, we review recent evidence on deregulated microRNAs upon pesticide exposure and possible role of deregulated miRNA and pesticides to PD pathogenesis.http://www.sciencedirect.com/science/article/pii/S2214750021000500Parkinson’s diseaseMetalsOxidative stressDopaminePesticidesmiRNAs |
| spellingShingle | Inam Ullah Longhe Zhao Yang Hai Muhammad Fahim Dhafer Alwayli Xin Wang Hongyu Li 'Metal elements and pesticides as risk factors for Parkinson's disease - A review' Toxicology Reports Parkinson’s disease Metals Oxidative stress Dopamine Pesticides miRNAs |
| title | 'Metal elements and pesticides as risk factors for Parkinson's disease - A review' |
| title_full | 'Metal elements and pesticides as risk factors for Parkinson's disease - A review' |
| title_fullStr | 'Metal elements and pesticides as risk factors for Parkinson's disease - A review' |
| title_full_unstemmed | 'Metal elements and pesticides as risk factors for Parkinson's disease - A review' |
| title_short | 'Metal elements and pesticides as risk factors for Parkinson's disease - A review' |
| title_sort | metal elements and pesticides as risk factors for parkinson s disease a review |
| topic | Parkinson’s disease Metals Oxidative stress Dopamine Pesticides miRNAs |
| url | http://www.sciencedirect.com/science/article/pii/S2214750021000500 |
| work_keys_str_mv | AT inamullah metalelementsandpesticidesasriskfactorsforparkinsonsdiseaseareview AT longhezhao metalelementsandpesticidesasriskfactorsforparkinsonsdiseaseareview AT yanghai metalelementsandpesticidesasriskfactorsforparkinsonsdiseaseareview AT muhammadfahim metalelementsandpesticidesasriskfactorsforparkinsonsdiseaseareview AT dhaferalwayli metalelementsandpesticidesasriskfactorsforparkinsonsdiseaseareview AT xinwang metalelementsandpesticidesasriskfactorsforparkinsonsdiseaseareview AT hongyuli metalelementsandpesticidesasriskfactorsforparkinsonsdiseaseareview |