Terpinen-4-ol, A volatile terpene molecule, extensively electrifies the biological systems against the oxidative stress-linked pathogenesis
Terpenes and their derivatives in essential oil have been raising an upstream interest due to their unwavering health-promoting effects and safety profiles, although the individual essential oil components are inadequately assessed for their biological potential. Terpinen-4-ol, a bioactive natural t...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Advances in Redox Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S266713792300022X |
| _version_ | 1797398448531570688 |
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| author | Jobaier Ibne Deen A.N.M. Shahriar Zawad Mijbah Uddin Muhammad Abid Hasan Chowdhury Salahuddin Qader Al Araby Md. Atiar Rahman |
| author_facet | Jobaier Ibne Deen A.N.M. Shahriar Zawad Mijbah Uddin Muhammad Abid Hasan Chowdhury Salahuddin Qader Al Araby Md. Atiar Rahman |
| author_sort | Jobaier Ibne Deen |
| collection | DOAJ |
| description | Terpenes and their derivatives in essential oil have been raising an upstream interest due to their unwavering health-promoting effects and safety profiles, although the individual essential oil components are inadequately assessed for their biological potential. Terpinen-4-ol, a bioactive natural terpene-derivative unambiguously distributed in most essential oil sources, is displaying a very remarkable role as a phytometabolite. This review, therefore, deciphered the health-promoting effects of Terpinen-4-ol in oxidative stress-linked diseases including neurodegenerative disorders, cancers, cardiovascular diseases, diabetes, and inflammatory disorders. Using Google as a search engine, this systematic review unraveled 217 relevant articles out of 857 search results from Web of Science, PubMed, and ScienceDirect. Terpinen-4-ol is reported to increase superoxide dismutase, decrease glutathione-S-transferase and acetylcholine esterase, inhibit NF-κB and NLRP3 inflammasome activation pathway, downregulate the α-amylase activity and increase insulin sensitivity, and substantially inhibit the generation of inflammatory mediators such as IL-1β, IL-6, IL-10. Despite several beneficial actions of Terpinen-4-ol, it has hardly been expedited to use as pharmaceutical therapeutic target for unveiled biological activities. In that context, this review has focused on the role of Terpinen-4-ol in attenuating oxidative stress and stress-linked pathophysiological conditions unraveling a research gap on it to manifest its best pharmaceutical and therapeutic uses. |
| first_indexed | 2024-03-09T01:25:44Z |
| format | Article |
| id | doaj.art-c709758031574aa49b75c0df9f37f17a |
| institution | Directory Open Access Journal |
| issn | 2667-1379 |
| language | English |
| last_indexed | 2024-03-09T01:25:44Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Advances in Redox Research |
| spelling | doaj.art-c709758031574aa49b75c0df9f37f17a2023-12-10T06:18:52ZengElsevierAdvances in Redox Research2667-13792023-12-019100082Terpinen-4-ol, A volatile terpene molecule, extensively electrifies the biological systems against the oxidative stress-linked pathogenesisJobaier Ibne Deen0A.N.M. Shahriar Zawad1Mijbah Uddin2Muhammad Abid Hasan Chowdhury3Salahuddin Qader Al Araby4Md. Atiar Rahman5Department of Biochemistry and Molecular Biology, University of Chittagong, Chittagong 4331, BangladeshDepartment of Biochemistry and Molecular Biology, University of Chittagong, Chittagong 4331, BangladeshDepartment of Biochemistry and Molecular Biology, University of Chittagong, Chittagong 4331, BangladeshBangladesh Tea Research Institute, Sreemangal-3210, Moulvibazar District, Sylhet 3100, BangladeshDepartment of Biochemistry and Molecular Biology, University of Chittagong, Chittagong 4331, BangladeshDepartment of Biochemistry and Molecular Biology, University of Chittagong, Chittagong 4331, Bangladesh; School of Allied Health Sciences, Walailak University, Nakhon Si, Thammarat 80160, Thailand; Corresponding author at: Department of Biochemistry & Molecular Biology, University of Chittagong, Chittagong 4331, Bangladesh.Terpenes and their derivatives in essential oil have been raising an upstream interest due to their unwavering health-promoting effects and safety profiles, although the individual essential oil components are inadequately assessed for their biological potential. Terpinen-4-ol, a bioactive natural terpene-derivative unambiguously distributed in most essential oil sources, is displaying a very remarkable role as a phytometabolite. This review, therefore, deciphered the health-promoting effects of Terpinen-4-ol in oxidative stress-linked diseases including neurodegenerative disorders, cancers, cardiovascular diseases, diabetes, and inflammatory disorders. Using Google as a search engine, this systematic review unraveled 217 relevant articles out of 857 search results from Web of Science, PubMed, and ScienceDirect. Terpinen-4-ol is reported to increase superoxide dismutase, decrease glutathione-S-transferase and acetylcholine esterase, inhibit NF-κB and NLRP3 inflammasome activation pathway, downregulate the α-amylase activity and increase insulin sensitivity, and substantially inhibit the generation of inflammatory mediators such as IL-1β, IL-6, IL-10. Despite several beneficial actions of Terpinen-4-ol, it has hardly been expedited to use as pharmaceutical therapeutic target for unveiled biological activities. In that context, this review has focused on the role of Terpinen-4-ol in attenuating oxidative stress and stress-linked pathophysiological conditions unraveling a research gap on it to manifest its best pharmaceutical and therapeutic uses.http://www.sciencedirect.com/science/article/pii/S266713792300022XTerpinen-4-olOxidative stressEssential oilCardioprotective effectsAntidiabetic effectsAnti-inflammatory effects |
| spellingShingle | Jobaier Ibne Deen A.N.M. Shahriar Zawad Mijbah Uddin Muhammad Abid Hasan Chowdhury Salahuddin Qader Al Araby Md. Atiar Rahman Terpinen-4-ol, A volatile terpene molecule, extensively electrifies the biological systems against the oxidative stress-linked pathogenesis Advances in Redox Research Terpinen-4-ol Oxidative stress Essential oil Cardioprotective effects Antidiabetic effects Anti-inflammatory effects |
| title | Terpinen-4-ol, A volatile terpene molecule, extensively electrifies the biological systems against the oxidative stress-linked pathogenesis |
| title_full | Terpinen-4-ol, A volatile terpene molecule, extensively electrifies the biological systems against the oxidative stress-linked pathogenesis |
| title_fullStr | Terpinen-4-ol, A volatile terpene molecule, extensively electrifies the biological systems against the oxidative stress-linked pathogenesis |
| title_full_unstemmed | Terpinen-4-ol, A volatile terpene molecule, extensively electrifies the biological systems against the oxidative stress-linked pathogenesis |
| title_short | Terpinen-4-ol, A volatile terpene molecule, extensively electrifies the biological systems against the oxidative stress-linked pathogenesis |
| title_sort | terpinen 4 ol a volatile terpene molecule extensively electrifies the biological systems against the oxidative stress linked pathogenesis |
| topic | Terpinen-4-ol Oxidative stress Essential oil Cardioprotective effects Antidiabetic effects Anti-inflammatory effects |
| url | http://www.sciencedirect.com/science/article/pii/S266713792300022X |
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