Polygenic risk score validation using Korean genomes of 265 early-onset acute myocardial infarction patients and 636 healthy controls.

Polygenic risk score validation using Korean genomes of 265 early-onset acute myocardial infarction patients and 636 healthy controls.

<h4>Background</h4>The polygenic risk score (PRS) developed for coronary artery disease (CAD) is known to be effective for classifying patients with CAD and predicting subsequent events. However, the PRS was developed mainly based on the analysis of Caucasian genomes and has not been val...

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Main Authors: Youngjune Bhak, Yeonsu Jeon, Sungwon Jeon, Changhan Yoon, Min Kim, Asta Blazyte, Yeonkyung Kim, Younghui Kang, Changjae Kim, Sang Yeub Lee, Jang-Whan Bae, Weon Kim, Yeo Jin Kim, Jungae Shim, Nayeong Kim, Sung Chun, Byoung-Chul Kim, Byung Chul Kim, Semin Lee, Jong Bhak, Eun-Seok Shin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0246538

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