Structure–Activity Relationships and Molecular Docking Analysis of Mcl-1 Targeting Renieramycin T Analogues in Patient-derived Lung Cancer Cells

Structure–Activity Relationships and Molecular Docking Analysis of Mcl-1 Targeting Renieramycin T Analogues in Patient-derived Lung Cancer Cells

Myeloid cell leukemia 1 (Mcl-1) and B-cell lymphoma 2 (Bcl-2) proteins are promising targets for cancer therapy. Here, we investigated the structure–activity relationships (SARs) and performed molecular docking analysis of renieramycin T (RT) and its analogues and identified the critical functional...

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Bibliographic Details
Main Authors:	Korrakod Petsri, Masashi Yokoya, Sucharat Tungsukruthai, Thanyada Rungrotmongkol, Bodee Nutho, Chanida Vinayanuwattikun, Naoki Saito, Takehiro Matsubara, Ryo Sato, Pithi Chanvorachote
Format:	Article
Language:	English
Published:	MDPI AG 2020-04-01
Series:	Cancers
Subjects:	renieramycin T Structure–Activity Relationship patient-derived primary lung cancer cells lung cancer apoptosis Mcl-1
Online Access:	https://www.mdpi.com/2072-6694/12/4/875

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