Ephrin-A/EphA specific co-adaptation as a novel mechanism in topographic axon guidance
Genetic hardwiring during brain development provides computational architectures for innate neuronal processing. Thus, the paradigmatic chick retinotectal projection, due to its neighborhood preserving, topographic organization, establishes millions of parallel channels for incremental visual field...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2017-07-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/25533 |
| _version_ | 1811181051788132352 |
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| author | Felix Fiederling Markus Weschenfelder Martin Fritz Anne von Philipsborn Martin Bastmeyer Franco Weth |
| author_facet | Felix Fiederling Markus Weschenfelder Martin Fritz Anne von Philipsborn Martin Bastmeyer Franco Weth |
| author_sort | Felix Fiederling |
| collection | DOAJ |
| description | Genetic hardwiring during brain development provides computational architectures for innate neuronal processing. Thus, the paradigmatic chick retinotectal projection, due to its neighborhood preserving, topographic organization, establishes millions of parallel channels for incremental visual field analysis. Retinal axons receive targeting information from quantitative guidance cue gradients. Surprisingly, novel adaptation assays demonstrate that retinal growth cones robustly adapt towards ephrin-A/EphA forward and reverse signals, which provide the major mapping cues. Computational modeling suggests that topographic accuracy and adaptability, though seemingly incompatible, could be reconciled by a novel mechanism of coupled adaptation of signaling channels. Experimentally, we find such ‘co-adaptation’ in retinal growth cones specifically for ephrin-A/EphA signaling. Co-adaptation involves trafficking of unliganded sensors between the surface membrane and recycling endosomes, and is presumably triggered by changes in the lipid composition of membrane microdomains. We propose that co-adaptative desensitization eventually relies on guidance sensor translocation into cis-signaling endosomes to outbalance repulsive trans-signaling. |
| first_indexed | 2024-04-11T09:13:09Z |
| format | Article |
| id | doaj.art-c70bfe9613d14cc6b3024c98c8830fb3 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-11T09:13:09Z |
| publishDate | 2017-07-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-c70bfe9613d14cc6b3024c98c8830fb32022-12-22T04:32:26ZengeLife Sciences Publications LtdeLife2050-084X2017-07-01610.7554/eLife.25533Ephrin-A/EphA specific co-adaptation as a novel mechanism in topographic axon guidanceFelix Fiederling0https://orcid.org/0000-0001-7837-5556Markus Weschenfelder1Martin Fritz2Anne von Philipsborn3https://orcid.org/0000-0002-7921-8744Martin Bastmeyer4Franco Weth5https://orcid.org/0000-0002-6819-7028Department of Cell and Neurobiology, Karlsruhe Institute of Technology, Zoological Institute, Karlruhe, GermanyDepartment of Cell and Neurobiology, Karlsruhe Institute of Technology, Zoological Institute, Karlruhe, GermanyDepartment of Cell and Neurobiology, Karlsruhe Institute of Technology, Zoological Institute, Karlruhe, GermanyDepartment of Cell and Neurobiology, Karlsruhe Institute of Technology, Zoological Institute, Karlruhe, GermanyDepartment of Cell and Neurobiology, Karlsruhe Institute of Technology, Zoological Institute, Karlruhe, GermanyDepartment of Cell and Neurobiology, Karlsruhe Institute of Technology, Zoological Institute, Karlruhe, GermanyGenetic hardwiring during brain development provides computational architectures for innate neuronal processing. Thus, the paradigmatic chick retinotectal projection, due to its neighborhood preserving, topographic organization, establishes millions of parallel channels for incremental visual field analysis. Retinal axons receive targeting information from quantitative guidance cue gradients. Surprisingly, novel adaptation assays demonstrate that retinal growth cones robustly adapt towards ephrin-A/EphA forward and reverse signals, which provide the major mapping cues. Computational modeling suggests that topographic accuracy and adaptability, though seemingly incompatible, could be reconciled by a novel mechanism of coupled adaptation of signaling channels. Experimentally, we find such ‘co-adaptation’ in retinal growth cones specifically for ephrin-A/EphA signaling. Co-adaptation involves trafficking of unliganded sensors between the surface membrane and recycling endosomes, and is presumably triggered by changes in the lipid composition of membrane microdomains. We propose that co-adaptative desensitization eventually relies on guidance sensor translocation into cis-signaling endosomes to outbalance repulsive trans-signaling.https://elifesciences.org/articles/25533Axon guidancegrowth coneretinotectalephrinEphtopographic map |
| spellingShingle | Felix Fiederling Markus Weschenfelder Martin Fritz Anne von Philipsborn Martin Bastmeyer Franco Weth Ephrin-A/EphA specific co-adaptation as a novel mechanism in topographic axon guidance eLife Axon guidance growth cone retinotectal ephrin Eph topographic map |
| title | Ephrin-A/EphA specific co-adaptation as a novel mechanism in topographic axon guidance |
| title_full | Ephrin-A/EphA specific co-adaptation as a novel mechanism in topographic axon guidance |
| title_fullStr | Ephrin-A/EphA specific co-adaptation as a novel mechanism in topographic axon guidance |
| title_full_unstemmed | Ephrin-A/EphA specific co-adaptation as a novel mechanism in topographic axon guidance |
| title_short | Ephrin-A/EphA specific co-adaptation as a novel mechanism in topographic axon guidance |
| title_sort | ephrin a epha specific co adaptation as a novel mechanism in topographic axon guidance |
| topic | Axon guidance growth cone retinotectal ephrin Eph topographic map |
| url | https://elifesciences.org/articles/25533 |
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