Long-term low-dose exposure of permethrin induces liver and kidney damage in rats
Abstract Background Permethrin is one of the pyrethroid insecticides, which is widely used in agriculture and public health. Although acute toxicity of the insecticide has been studied, the chronic toxicity upon the long-term exposure has not been clear yet. The purpose of the current study is to in...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-07-01
|
| Series: | BMC Pharmacology and Toxicology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40360-022-00586-2 |
| _version_ | 1828774779209908224 |
|---|---|
| author | Ying-Jian Sun Yu-Jie Liang Lin Yang Ding-Xin Long Hui-Ping Wang Yi-Jun Wu |
| author_facet | Ying-Jian Sun Yu-Jie Liang Lin Yang Ding-Xin Long Hui-Ping Wang Yi-Jun Wu |
| author_sort | Ying-Jian Sun |
| collection | DOAJ |
| description | Abstract Background Permethrin is one of the pyrethroid insecticides, which is widely used in agriculture and public health. Although acute toxicity of the insecticide has been studied, the chronic toxicity upon the long-term exposure has not been clear yet. The purpose of the current study is to investigate the organ toxicities of permethrin following its long-term low-dose exposure. Methods Male Wistar rats were daily administrated orally with permethrin (75 mg/kg body weight/day, gavage) for 90 days, and then the samples of biofluids (blood and urine) and organs including liver and kidney were collected. The serum and urine samples were measured by biochemical assay and the tissues of kidney and liver were examined and analyzed by histopathological method. Results The results showed that no change was found in serum and urine biochemical parameters for the toxicity; however, significant changes including hyperchromatic nuclei swollen in the hepatic parenchymal cells and the swelling proximal tubules in the kidneys were observed in the tissue structures of liver and kidneys in the histopathological sections. Conclusion These results indicate that low-dose long-term exposure of permethrin can cause chronic toxicity with slight liver and kidney damage. |
| first_indexed | 2024-12-11T15:28:24Z |
| format | Article |
| id | doaj.art-c70f0876691a4590a84f89d57e0aa544 |
| institution | Directory Open Access Journal |
| issn | 2050-6511 |
| language | English |
| last_indexed | 2024-12-11T15:28:24Z |
| publishDate | 2022-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pharmacology and Toxicology |
| spelling | doaj.art-c70f0876691a4590a84f89d57e0aa5442022-12-22T01:00:09ZengBMCBMC Pharmacology and Toxicology2050-65112022-07-012311510.1186/s40360-022-00586-2Long-term low-dose exposure of permethrin induces liver and kidney damage in ratsYing-Jian Sun0Yu-Jie Liang1Lin Yang2Ding-Xin Long3Hui-Ping Wang4Yi-Jun Wu5Laboratory of Molecular Toxicology, Institute of Zoology, Chinese Academy of SciencesLaboratory of Molecular Toxicology, Institute of Zoology, Chinese Academy of SciencesLaboratory of Molecular Toxicology, Institute of Zoology, Chinese Academy of SciencesLaboratory of Molecular Toxicology, Institute of Zoology, Chinese Academy of SciencesLaboratory of Molecular Toxicology, Institute of Zoology, Chinese Academy of SciencesLaboratory of Molecular Toxicology, Institute of Zoology, Chinese Academy of SciencesAbstract Background Permethrin is one of the pyrethroid insecticides, which is widely used in agriculture and public health. Although acute toxicity of the insecticide has been studied, the chronic toxicity upon the long-term exposure has not been clear yet. The purpose of the current study is to investigate the organ toxicities of permethrin following its long-term low-dose exposure. Methods Male Wistar rats were daily administrated orally with permethrin (75 mg/kg body weight/day, gavage) for 90 days, and then the samples of biofluids (blood and urine) and organs including liver and kidney were collected. The serum and urine samples were measured by biochemical assay and the tissues of kidney and liver were examined and analyzed by histopathological method. Results The results showed that no change was found in serum and urine biochemical parameters for the toxicity; however, significant changes including hyperchromatic nuclei swollen in the hepatic parenchymal cells and the swelling proximal tubules in the kidneys were observed in the tissue structures of liver and kidneys in the histopathological sections. Conclusion These results indicate that low-dose long-term exposure of permethrin can cause chronic toxicity with slight liver and kidney damage.https://doi.org/10.1186/s40360-022-00586-2InsecticidePyrethroidLong-term low-dose exposureHistopathologyHepatotoxicityNephrotoxicity |
| spellingShingle | Ying-Jian Sun Yu-Jie Liang Lin Yang Ding-Xin Long Hui-Ping Wang Yi-Jun Wu Long-term low-dose exposure of permethrin induces liver and kidney damage in rats BMC Pharmacology and Toxicology Insecticide Pyrethroid Long-term low-dose exposure Histopathology Hepatotoxicity Nephrotoxicity |
| title | Long-term low-dose exposure of permethrin induces liver and kidney damage in rats |
| title_full | Long-term low-dose exposure of permethrin induces liver and kidney damage in rats |
| title_fullStr | Long-term low-dose exposure of permethrin induces liver and kidney damage in rats |
| title_full_unstemmed | Long-term low-dose exposure of permethrin induces liver and kidney damage in rats |
| title_short | Long-term low-dose exposure of permethrin induces liver and kidney damage in rats |
| title_sort | long term low dose exposure of permethrin induces liver and kidney damage in rats |
| topic | Insecticide Pyrethroid Long-term low-dose exposure Histopathology Hepatotoxicity Nephrotoxicity |
| url | https://doi.org/10.1186/s40360-022-00586-2 |
| work_keys_str_mv | AT yingjiansun longtermlowdoseexposureofpermethrininducesliverandkidneydamageinrats AT yujieliang longtermlowdoseexposureofpermethrininducesliverandkidneydamageinrats AT linyang longtermlowdoseexposureofpermethrininducesliverandkidneydamageinrats AT dingxinlong longtermlowdoseexposureofpermethrininducesliverandkidneydamageinrats AT huipingwang longtermlowdoseexposureofpermethrininducesliverandkidneydamageinrats AT yijunwu longtermlowdoseexposureofpermethrininducesliverandkidneydamageinrats |