Cardioprotective potential of hydro-alcoholic fruit extract of Ananas comosus against isoproterenol induced myocardial infraction in Wistar Albino rats.
Objectives: To evaluate the cardioprotective effects of hydro alcoholic extract of Ananas comosus (A. comosus) (HEAC), on Isoproterenol (ISO) induced myocardial infarction in Albino Wistar rats. Methods: Myocardial infarction was induced by Isoproterenol (85 mg/kg, s.c.) for two consecutive days at...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2014-01-01
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| Series: | Journal of Acute Disease |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2221618914600512 |
| _version_ | 1818481364267171840 |
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| author | Priya Saxena Dharamveer Panjwani |
| author_facet | Priya Saxena Dharamveer Panjwani |
| author_sort | Priya Saxena |
| collection | DOAJ |
| description | Objectives: To evaluate the cardioprotective effects of hydro alcoholic extract of Ananas comosus (A. comosus) (HEAC), on Isoproterenol (ISO) induced myocardial infarction in Albino Wistar rats.
Methods: Myocardial infarction was induced by Isoproterenol (85 mg/kg, s.c.) for two consecutive days at an interval of 24 h. Rats were pretreated with HEAC (200–400 mg/kg/day, oral) for a period of 30 days and Isoproterenol (ISO) was injected on 31st and 32nd day and after 24 h blood was collected through retro-orbital plexus for the estimation of biochemical parameters and histopathological studies were also performed.
Results: In the present study, ISO administration significantly elevated the cholesterol, low density lipoprotein, very low density lipoprotein, triglycerides, alanine aminotransferase and aspartate aminotransferase levels while it decreases high density lipoprotein and total protein in plasma and administration of HEAC decreases the level of cholesterol, low density lipoprotein, very low density lipoprotein, triglycerides, alanine aminotransferase and aspartate aminotransferase levels while it increases high density lipoprotein and total protein levels. Pretreatment with the HEAC protected the cardiotoxicity induced by Isoproterenol. The histopathological findings of the ISO-induced myocardium showed infracted zone with inflammatory cells, lipid droplets, myocardial necrosis and vacuolization of myofibrils which were reduced by the pretreatment of HEAC.
Conclusion: It can be concluded that HEAC possess cardioprotective activity against Isoproterenol induced myocardial infarction in rats. |
| first_indexed | 2024-12-10T11:33:54Z |
| format | Article |
| id | doaj.art-c70f36a717754424b0e504c3c1a9ddc7 |
| institution | Directory Open Access Journal |
| issn | 2221-6189 |
| language | English |
| last_indexed | 2024-12-10T11:33:54Z |
| publishDate | 2014-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Acute Disease |
| spelling | doaj.art-c70f36a717754424b0e504c3c1a9ddc72022-12-22T01:50:29ZengWolters Kluwer Medknow PublicationsJournal of Acute Disease2221-61892014-01-013322823410.1016/S2221-6189(14)60051-2Cardioprotective potential of hydro-alcoholic fruit extract of Ananas comosus against isoproterenol induced myocardial infraction in Wistar Albino rats.Priya SaxenaDharamveer PanjwaniObjectives: To evaluate the cardioprotective effects of hydro alcoholic extract of Ananas comosus (A. comosus) (HEAC), on Isoproterenol (ISO) induced myocardial infarction in Albino Wistar rats. Methods: Myocardial infarction was induced by Isoproterenol (85 mg/kg, s.c.) for two consecutive days at an interval of 24 h. Rats were pretreated with HEAC (200–400 mg/kg/day, oral) for a period of 30 days and Isoproterenol (ISO) was injected on 31st and 32nd day and after 24 h blood was collected through retro-orbital plexus for the estimation of biochemical parameters and histopathological studies were also performed. Results: In the present study, ISO administration significantly elevated the cholesterol, low density lipoprotein, very low density lipoprotein, triglycerides, alanine aminotransferase and aspartate aminotransferase levels while it decreases high density lipoprotein and total protein in plasma and administration of HEAC decreases the level of cholesterol, low density lipoprotein, very low density lipoprotein, triglycerides, alanine aminotransferase and aspartate aminotransferase levels while it increases high density lipoprotein and total protein levels. Pretreatment with the HEAC protected the cardiotoxicity induced by Isoproterenol. The histopathological findings of the ISO-induced myocardium showed infracted zone with inflammatory cells, lipid droplets, myocardial necrosis and vacuolization of myofibrils which were reduced by the pretreatment of HEAC. Conclusion: It can be concluded that HEAC possess cardioprotective activity against Isoproterenol induced myocardial infarction in rats.http://www.sciencedirect.com/science/article/pii/S2221618914600512Ananas comosusIsoproterenolCardiotoxicityMyocardial infarction |
| spellingShingle | Priya Saxena Dharamveer Panjwani Cardioprotective potential of hydro-alcoholic fruit extract of Ananas comosus against isoproterenol induced myocardial infraction in Wistar Albino rats. Journal of Acute Disease Ananas comosus Isoproterenol Cardiotoxicity Myocardial infarction |
| title | Cardioprotective potential of hydro-alcoholic fruit extract of Ananas comosus against isoproterenol induced myocardial infraction in Wistar Albino rats. |
| title_full | Cardioprotective potential of hydro-alcoholic fruit extract of Ananas comosus against isoproterenol induced myocardial infraction in Wistar Albino rats. |
| title_fullStr | Cardioprotective potential of hydro-alcoholic fruit extract of Ananas comosus against isoproterenol induced myocardial infraction in Wistar Albino rats. |
| title_full_unstemmed | Cardioprotective potential of hydro-alcoholic fruit extract of Ananas comosus against isoproterenol induced myocardial infraction in Wistar Albino rats. |
| title_short | Cardioprotective potential of hydro-alcoholic fruit extract of Ananas comosus against isoproterenol induced myocardial infraction in Wistar Albino rats. |
| title_sort | cardioprotective potential of hydro alcoholic fruit extract of ananas comosus against isoproterenol induced myocardial infraction in wistar albino rats |
| topic | Ananas comosus Isoproterenol Cardiotoxicity Myocardial infarction |
| url | http://www.sciencedirect.com/science/article/pii/S2221618914600512 |
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