Antibody titres in fully vaccinated healthcare workers with and without breakthrough infection during the Delta and Omicron waves
Introduction: Assessment of antibody response to vaccination against SARS CoV2 has clinical, public health, and policy implications during the pandemic and in the context of future waves. Method: In this repeated cross-sectional study, we estimated total binding antibody levels to the spike protein...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2023-07-01
|
| Series: | Journal of Family Medicine and Primary Care |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/jfmpc.jfmpc_1809_22 |
| _version_ | 1826982665634447360 |
|---|---|
| author | Sindhulina Chandrasingh Carolin E. George Leeberk R. Inbaraj Tatarao Maddipati |
| author_facet | Sindhulina Chandrasingh Carolin E. George Leeberk R. Inbaraj Tatarao Maddipati |
| author_sort | Sindhulina Chandrasingh |
| collection | DOAJ |
| description | Introduction:
Assessment of antibody response to vaccination against SARS CoV2 has clinical, public health, and policy implications during the pandemic and in the context of future waves.
Method:
In this repeated cross-sectional study, we estimated total binding antibody levels to the spike protein of the SARS CoV2 virus post two doses of Covishield vaccine among 133 health care workers (HCWs) (phase 1), followed by antibody levels among a subset (n = 61) of this group at 9 months after the second dose (phase 2). The time period of the first and second blood collection corresponds to Delta and Omicron waves, respectively.
Results:
We report 100% seroconversion post 28 days of the second dose of the Covishield vaccine among infection naïve HCWs. In this study, 33% had a breakthrough infection in phase 1 and 24% reported a history of infection in phase 2. The antibody titres were higher in the breakthrough infection group compared to the infection naïve group during both Delta and Omicron waves.
Conclusion:
This shows that there is a good seroconversion with two doses of vaccine, weaning of antibody with time, and a rise of antibody titre if infected with SARS CoV 2 subsequently. |
| first_indexed | 2024-03-12T13:45:23Z |
| format | Article |
| id | doaj.art-c711f59d3c79466b85a61f2119670663 |
| institution | Directory Open Access Journal |
| issn | 2249-4863 2278-7135 |
| language | English |
| last_indexed | 2025-02-18T06:24:13Z |
| publishDate | 2023-07-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Family Medicine and Primary Care |
| spelling | doaj.art-c711f59d3c79466b85a61f21196706632024-11-11T11:08:10ZengWolters Kluwer Medknow PublicationsJournal of Family Medicine and Primary Care2249-48632278-71352023-07-011271298130210.4103/jfmpc.jfmpc_1809_22Antibody titres in fully vaccinated healthcare workers with and without breakthrough infection during the Delta and Omicron wavesSindhulina ChandrasinghCarolin E. GeorgeLeeberk R. InbarajTatarao MaddipatiIntroduction: Assessment of antibody response to vaccination against SARS CoV2 has clinical, public health, and policy implications during the pandemic and in the context of future waves. Method: In this repeated cross-sectional study, we estimated total binding antibody levels to the spike protein of the SARS CoV2 virus post two doses of Covishield vaccine among 133 health care workers (HCWs) (phase 1), followed by antibody levels among a subset (n = 61) of this group at 9 months after the second dose (phase 2). The time period of the first and second blood collection corresponds to Delta and Omicron waves, respectively. Results: We report 100% seroconversion post 28 days of the second dose of the Covishield vaccine among infection naïve HCWs. In this study, 33% had a breakthrough infection in phase 1 and 24% reported a history of infection in phase 2. The antibody titres were higher in the breakthrough infection group compared to the infection naïve group during both Delta and Omicron waves. Conclusion: This shows that there is a good seroconversion with two doses of vaccine, weaning of antibody with time, and a rise of antibody titre if infected with SARS CoV 2 subsequently.https://journals.lww.com/10.4103/jfmpc.jfmpc_1809_22breakthrough infectiondelta wavehealth care workers (hcws)omicron wavepost-vaccination antibody titresars cov2 |
| spellingShingle | Sindhulina Chandrasingh Carolin E. George Leeberk R. Inbaraj Tatarao Maddipati Antibody titres in fully vaccinated healthcare workers with and without breakthrough infection during the Delta and Omicron waves Journal of Family Medicine and Primary Care breakthrough infection delta wave health care workers (hcws) omicron wave post-vaccination antibody titre sars cov2 |
| title | Antibody titres in fully vaccinated healthcare workers with and without breakthrough infection during the Delta and Omicron waves |
| title_full | Antibody titres in fully vaccinated healthcare workers with and without breakthrough infection during the Delta and Omicron waves |
| title_fullStr | Antibody titres in fully vaccinated healthcare workers with and without breakthrough infection during the Delta and Omicron waves |
| title_full_unstemmed | Antibody titres in fully vaccinated healthcare workers with and without breakthrough infection during the Delta and Omicron waves |
| title_short | Antibody titres in fully vaccinated healthcare workers with and without breakthrough infection during the Delta and Omicron waves |
| title_sort | antibody titres in fully vaccinated healthcare workers with and without breakthrough infection during the delta and omicron waves |
| topic | breakthrough infection delta wave health care workers (hcws) omicron wave post-vaccination antibody titre sars cov2 |
| url | https://journals.lww.com/10.4103/jfmpc.jfmpc_1809_22 |
| work_keys_str_mv | AT sindhulinachandrasingh antibodytitresinfullyvaccinatedhealthcareworkerswithandwithoutbreakthroughinfectionduringthedeltaandomicronwaves AT carolinegeorge antibodytitresinfullyvaccinatedhealthcareworkerswithandwithoutbreakthroughinfectionduringthedeltaandomicronwaves AT leeberkrinbaraj antibodytitresinfullyvaccinatedhealthcareworkerswithandwithoutbreakthroughinfectionduringthedeltaandomicronwaves AT tataraomaddipati antibodytitresinfullyvaccinatedhealthcareworkerswithandwithoutbreakthroughinfectionduringthedeltaandomicronwaves |