Epithelial-mesenchymal Transition and Tumor Metastasis
Metastasis is the transfer of malignant tumors from one organ to a distant organ. It is the most common cause of death in cancer patients. Different molecular mechanisms enable tumor cells to infiltrate the surrounding tissue, invade blood vessels and leave the blood stream at a different site. Epit...
| Main Authors: | , , |
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| Format: | Article |
| Language: | zho |
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Chinese Anti-Cancer Association; Chinese Antituberculosis Association
2011-07-01
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| Series: | Chinese Journal of Lung Cancer |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.3779/j.issn.1009-3419.2011.07.11 |
| _version_ | 1818850526631034880 |
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| author | Rongzhi ZHAO Zhihao WU Qinghua ZHOU |
| author_facet | Rongzhi ZHAO Zhihao WU Qinghua ZHOU |
| author_sort | Rongzhi ZHAO |
| collection | DOAJ |
| description | Metastasis is the transfer of malignant tumors from one organ to a distant organ. It is the most common cause of death in cancer patients. Different molecular mechanisms enable tumor cells to infiltrate the surrounding tissue, invade blood vessels and leave the blood stream at a different site. Epithelial-mesenchymal transition (EMT) is critical for appropriate embryonic development, and this process is re-engaged in adults during wound healing, tissue regeneration, organ fibrosis, and cancer progression. EMT is the first step in tumor invasion and metastasis. A detailed knowledge of the molecular requirements for EMT in human cancer will help us to better understand tumor progression and to delineate more effective strategies for future therapeutic intervention. |
| first_indexed | 2024-12-19T06:50:32Z |
| format | Article |
| id | doaj.art-c713970da3474d4085e4dcbe99322781 |
| institution | Directory Open Access Journal |
| issn | 1009-3419 1999-6187 |
| language | zho |
| last_indexed | 2024-12-19T06:50:32Z |
| publishDate | 2011-07-01 |
| publisher | Chinese Anti-Cancer Association; Chinese Antituberculosis Association |
| record_format | Article |
| series | Chinese Journal of Lung Cancer |
| spelling | doaj.art-c713970da3474d4085e4dcbe993227812022-12-21T20:31:45ZzhoChinese Anti-Cancer Association; Chinese Antituberculosis AssociationChinese Journal of Lung Cancer1009-34191999-61872011-07-0114762062410.3779/j.issn.1009-3419.2011.07.11Epithelial-mesenchymal Transition and Tumor MetastasisRongzhi ZHAOZhihao WUQinghua ZHOUMetastasis is the transfer of malignant tumors from one organ to a distant organ. It is the most common cause of death in cancer patients. Different molecular mechanisms enable tumor cells to infiltrate the surrounding tissue, invade blood vessels and leave the blood stream at a different site. Epithelial-mesenchymal transition (EMT) is critical for appropriate embryonic development, and this process is re-engaged in adults during wound healing, tissue regeneration, organ fibrosis, and cancer progression. EMT is the first step in tumor invasion and metastasis. A detailed knowledge of the molecular requirements for EMT in human cancer will help us to better understand tumor progression and to delineate more effective strategies for future therapeutic intervention.http://dx.doi.org/10.3779/j.issn.1009-3419.2011.07.11Epithelial-mesenchymal transitionTumor invasionMetastasis |
| spellingShingle | Rongzhi ZHAO Zhihao WU Qinghua ZHOU Epithelial-mesenchymal Transition and Tumor Metastasis Chinese Journal of Lung Cancer Epithelial-mesenchymal transition Tumor invasion Metastasis |
| title | Epithelial-mesenchymal Transition and Tumor Metastasis |
| title_full | Epithelial-mesenchymal Transition and Tumor Metastasis |
| title_fullStr | Epithelial-mesenchymal Transition and Tumor Metastasis |
| title_full_unstemmed | Epithelial-mesenchymal Transition and Tumor Metastasis |
| title_short | Epithelial-mesenchymal Transition and Tumor Metastasis |
| title_sort | epithelial mesenchymal transition and tumor metastasis |
| topic | Epithelial-mesenchymal transition Tumor invasion Metastasis |
| url | http://dx.doi.org/10.3779/j.issn.1009-3419.2011.07.11 |
| work_keys_str_mv | AT rongzhizhao epithelialmesenchymaltransitionandtumormetastasis AT zhihaowu epithelialmesenchymaltransitionandtumormetastasis AT qinghuazhou epithelialmesenchymaltransitionandtumormetastasis |