Designing Vaccines to Neutralize Effective Toxin Delivery by Enterotoxigenic Escherichia coli
Enterotoxigenic Escherichia coli (ETEC) are a leading cause of diarrheal illness in developing countries. Despite the discovery of these pathogens as a cause of cholera-like diarrhea over 40 years ago, and decades of vaccine development effort, there remains no broadly protective ETEC vaccine. The d...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2014-06-01
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| Series: | Toxins |
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| Online Access: | http://www.mdpi.com/2072-6651/6/6/1799 |
| _version_ | 1798025859791060992 |
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| author | James M. Fleckenstein Alaullah Sheikh |
| author_facet | James M. Fleckenstein Alaullah Sheikh |
| author_sort | James M. Fleckenstein |
| collection | DOAJ |
| description | Enterotoxigenic Escherichia coli (ETEC) are a leading cause of diarrheal illness in developing countries. Despite the discovery of these pathogens as a cause of cholera-like diarrhea over 40 years ago, and decades of vaccine development effort, there remains no broadly protective ETEC vaccine. The discovery of new virulence proteins and an improved appreciation of the complexity of the molecular events required for effective toxin delivery may provide additional avenues to pursue in development of an effective vaccine to prevent severe diarrhea caused by these important pathogens. |
| first_indexed | 2024-04-11T18:25:42Z |
| format | Article |
| id | doaj.art-c713d1d8f1e745f988c190b9761e4ea1 |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-04-11T18:25:42Z |
| publishDate | 2014-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-c713d1d8f1e745f988c190b9761e4ea12022-12-22T04:09:37ZengMDPI AGToxins2072-66512014-06-01661799181210.3390/toxins6061799toxins6061799Designing Vaccines to Neutralize Effective Toxin Delivery by Enterotoxigenic Escherichia coliJames M. Fleckenstein0Alaullah Sheikh1Division of Infectious Diseases, Washington University School of Medicine, 660 South Euclid Avenue; Saint Louis, MO 63110, USAMolecular Microbiology and Microbiobial Pathogenesis Program, Division of Biology and Biomedical Sciences, Washington University School of Medicine, Campus Box 8051, 660 South Euclid Avenue; Saint Louis, MO 63110, USAEnterotoxigenic Escherichia coli (ETEC) are a leading cause of diarrheal illness in developing countries. Despite the discovery of these pathogens as a cause of cholera-like diarrhea over 40 years ago, and decades of vaccine development effort, there remains no broadly protective ETEC vaccine. The discovery of new virulence proteins and an improved appreciation of the complexity of the molecular events required for effective toxin delivery may provide additional avenues to pursue in development of an effective vaccine to prevent severe diarrhea caused by these important pathogens.http://www.mdpi.com/2072-6651/6/6/1799enterotoxindiarrheaneutralizing antibodiesheat-labile enterotoxinheat-stable enterotoxinenterotoxigenic Escherichia colivaccinessubunitvaccineslive-attenuated |
| spellingShingle | James M. Fleckenstein Alaullah Sheikh Designing Vaccines to Neutralize Effective Toxin Delivery by Enterotoxigenic Escherichia coli Toxins enterotoxin diarrhea neutralizing antibodies heat-labile enterotoxin heat-stable enterotoxin enterotoxigenic Escherichia coli vaccines subunit vaccines live-attenuated |
| title | Designing Vaccines to Neutralize Effective Toxin Delivery by Enterotoxigenic Escherichia coli |
| title_full | Designing Vaccines to Neutralize Effective Toxin Delivery by Enterotoxigenic Escherichia coli |
| title_fullStr | Designing Vaccines to Neutralize Effective Toxin Delivery by Enterotoxigenic Escherichia coli |
| title_full_unstemmed | Designing Vaccines to Neutralize Effective Toxin Delivery by Enterotoxigenic Escherichia coli |
| title_short | Designing Vaccines to Neutralize Effective Toxin Delivery by Enterotoxigenic Escherichia coli |
| title_sort | designing vaccines to neutralize effective toxin delivery by enterotoxigenic escherichia coli |
| topic | enterotoxin diarrhea neutralizing antibodies heat-labile enterotoxin heat-stable enterotoxin enterotoxigenic Escherichia coli vaccines subunit vaccines live-attenuated |
| url | http://www.mdpi.com/2072-6651/6/6/1799 |
| work_keys_str_mv | AT jamesmfleckenstein designingvaccinestoneutralizeeffectivetoxindeliverybyenterotoxigenicescherichiacoli AT alaullahsheikh designingvaccinestoneutralizeeffectivetoxindeliverybyenterotoxigenicescherichiacoli |