Effects of glutamine alone or in combination with zinc and vitamin A on growth, intestinal barrier function, stress and satiety-related hormones in Brazilian shantytown children
OBJECTIVE: To determine the impact of supplemental zinc, vitamin A, and glutamine alone or in combination on growth, intestinal barrier function, stress and satiety-related hormones among Brazilian shantytown children with low median height-for-age z-scores. METHODS: A randomized, double-blind, pla...
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| Format: | Article |
| Language: | English |
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Elsevier España
2014-04-01
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| Series: | Clinics |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322014000400225&lng=en&tlng=en |
| _version_ | 1818119255687692288 |
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| author | Aldo A.M. Lima Gregory M. Anstead Qiong Zhang Ítalo L. Figueiredo Alberto M. Soares Rosa M.S. Mota Noélia L. Lima Richard L. Guerrant Reinaldo B. Oriá |
| author_facet | Aldo A.M. Lima Gregory M. Anstead Qiong Zhang Ítalo L. Figueiredo Alberto M. Soares Rosa M.S. Mota Noélia L. Lima Richard L. Guerrant Reinaldo B. Oriá |
| author_sort | Aldo A.M. Lima |
| collection | DOAJ |
| description | OBJECTIVE: To determine the impact of supplemental zinc, vitamin A, and glutamine alone or in combination on growth, intestinal barrier function, stress and satiety-related hormones among Brazilian shantytown children with low median height-for-age z-scores. METHODS: A randomized, double-blind, placebo-controlled trial was conducted in children aged two months to nine years from the urban shanty compound community of Fortaleza, Brazil. Demographic and anthropometric information was assessed. The random treatment groups available for testing (a total of 120 children) were as follows: (1) glutamine alone, n = 38; (2) glutamine plus vitamin A plus zinc, n = 37; and a placebo (zinc plus vitamin A vehicle) plus glycine (isonitrogenous to glutamine) control treatment, n = 38. Leptin, adiponectin, insulin-like growth factor (IGF-1), and plasma levels of cortisol were measured with immune-enzymatic assays; urinary lactulose/mannitol and serum amino acids were measured with high-performance liquid chromatography. ClinicalTrials.gov: NCT00133406. RESULTS: Glutamine treatment significantly improved weight-for-height z-scores compared to the placebo-glycine control treatment. Either glutamine alone or all nutrients combined prevented disruption of the intestinal barrier function, as measured by the percentage of lactulose urinary excretion and the lactulose:mannitol absorption ratio. Plasma leptin was negatively correlated with plasma glutamine (p = 0.002) and arginine (p = 0.001) levels at baseline. After glutamine treatment, leptin was correlated with weight-for-age (WAZ) and weight-for-height z-scores (WHZ) (p≤0.002) at a 4-month follow-up. In addition, glutamine and all combined nutrients (glutamine, vitamin A, and zinc) improved the intestinal barrier function in these children. CONCLUSION: Taken together, these findings reveal the benefits of glutamine alone or in combination with other gut-trophic nutrients in growing children via interactions with leptin. |
| first_indexed | 2024-12-11T05:07:18Z |
| format | Article |
| id | doaj.art-c715e44419c44ec493d4cc7fee77f5ba |
| institution | Directory Open Access Journal |
| issn | 1980-5322 |
| language | English |
| last_indexed | 2024-12-11T05:07:18Z |
| publishDate | 2014-04-01 |
| publisher | Elsevier España |
| record_format | Article |
| series | Clinics |
| spelling | doaj.art-c715e44419c44ec493d4cc7fee77f5ba2022-12-22T01:19:59ZengElsevier EspañaClinics1980-53222014-04-0169422523310.6061/clinics/2014(04)02S1807-59322014000400225Effects of glutamine alone or in combination with zinc and vitamin A on growth, intestinal barrier function, stress and satiety-related hormones in Brazilian shantytown childrenAldo A.M. LimaGregory M. AnsteadQiong ZhangÍtalo L. FigueiredoAlberto M. SoaresRosa M.S. MotaNoélia L. LimaRichard L. GuerrantReinaldo B. OriáOBJECTIVE: To determine the impact of supplemental zinc, vitamin A, and glutamine alone or in combination on growth, intestinal barrier function, stress and satiety-related hormones among Brazilian shantytown children with low median height-for-age z-scores. METHODS: A randomized, double-blind, placebo-controlled trial was conducted in children aged two months to nine years from the urban shanty compound community of Fortaleza, Brazil. Demographic and anthropometric information was assessed. The random treatment groups available for testing (a total of 120 children) were as follows: (1) glutamine alone, n = 38; (2) glutamine plus vitamin A plus zinc, n = 37; and a placebo (zinc plus vitamin A vehicle) plus glycine (isonitrogenous to glutamine) control treatment, n = 38. Leptin, adiponectin, insulin-like growth factor (IGF-1), and plasma levels of cortisol were measured with immune-enzymatic assays; urinary lactulose/mannitol and serum amino acids were measured with high-performance liquid chromatography. ClinicalTrials.gov: NCT00133406. RESULTS: Glutamine treatment significantly improved weight-for-height z-scores compared to the placebo-glycine control treatment. Either glutamine alone or all nutrients combined prevented disruption of the intestinal barrier function, as measured by the percentage of lactulose urinary excretion and the lactulose:mannitol absorption ratio. Plasma leptin was negatively correlated with plasma glutamine (p = 0.002) and arginine (p = 0.001) levels at baseline. After glutamine treatment, leptin was correlated with weight-for-age (WAZ) and weight-for-height z-scores (WHZ) (p≤0.002) at a 4-month follow-up. In addition, glutamine and all combined nutrients (glutamine, vitamin A, and zinc) improved the intestinal barrier function in these children. CONCLUSION: Taken together, these findings reveal the benefits of glutamine alone or in combination with other gut-trophic nutrients in growing children via interactions with leptin.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322014000400225&lng=en&tlng=enMicronutrientsStressGrowth and DevelopmentIntestinal Barrier FunctionHormonal Biomarkers |
| spellingShingle | Aldo A.M. Lima Gregory M. Anstead Qiong Zhang Ítalo L. Figueiredo Alberto M. Soares Rosa M.S. Mota Noélia L. Lima Richard L. Guerrant Reinaldo B. Oriá Effects of glutamine alone or in combination with zinc and vitamin A on growth, intestinal barrier function, stress and satiety-related hormones in Brazilian shantytown children Clinics Micronutrients Stress Growth and Development Intestinal Barrier Function Hormonal Biomarkers |
| title | Effects of glutamine alone or in combination with zinc and vitamin A on growth, intestinal barrier function, stress and satiety-related hormones in Brazilian shantytown children |
| title_full | Effects of glutamine alone or in combination with zinc and vitamin A on growth, intestinal barrier function, stress and satiety-related hormones in Brazilian shantytown children |
| title_fullStr | Effects of glutamine alone or in combination with zinc and vitamin A on growth, intestinal barrier function, stress and satiety-related hormones in Brazilian shantytown children |
| title_full_unstemmed | Effects of glutamine alone or in combination with zinc and vitamin A on growth, intestinal barrier function, stress and satiety-related hormones in Brazilian shantytown children |
| title_short | Effects of glutamine alone or in combination with zinc and vitamin A on growth, intestinal barrier function, stress and satiety-related hormones in Brazilian shantytown children |
| title_sort | effects of glutamine alone or in combination with zinc and vitamin a on growth intestinal barrier function stress and satiety related hormones in brazilian shantytown children |
| topic | Micronutrients Stress Growth and Development Intestinal Barrier Function Hormonal Biomarkers |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322014000400225&lng=en&tlng=en |
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