Effect of Lump Size and Nodal Status on Prognosis in Invasive Breast Cancer: Experience from Rural India
Introduction: Breast cancer is now the leading cause of cancer among Indian women. Usually large tumour size and axillary lymph node involvement are linked with adverse outcome and this notion forms the basis of screening programs i.e. early detection. Aim: The present study was carried out to...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2016-06-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/8039/20470_CE[Ra1]_F(GH)_PF1(ROAK)_PFA(AK)_PF2(PAG).pdf |
| Summary: | Introduction: Breast cancer is now the leading cause of cancer
among Indian women. Usually large tumour size and axillary
lymph node involvement are linked with adverse outcome and
this notion forms the basis of screening programs i.e. early
detection.
Aim: The present study was carried out to analyse relationship
between tumour size, lymph node status and there relation with
outcome after treatment.
Materials and Methods: Fifty patients with cytology-proven
invasive breast tumours were evaluated for size, clinical and
pathologic characteristics of tumour, axillary lymph node status
and outcome data recorded on sequential follow-up.
Results: Mean age of all participated patients was 52.24±10
years. Most common tumour location was in the upper outer
quadrant with mean size of primary tumour being 3.31±1.80cm.
On pathology number of lymph nodes examined ranged from
10 to 24 and 72% of patients recorded presence of disease
in axilla. Significant positive correlation (p<0.013; r2
=0.026)
between tumour size and axillary lymph node involvement on
linear regression. Also an indicative correlation between size
and grade of tumour and axillary lymph node status was found
with survival from the disease.
Conclusion: The present study highlights that the size of the
primary tumour and the number of positive lymph nodes have
an inverse linear relationship with prognosis. Despite advances
in diagnostic modalities, evolution of newer markers and genetic
typing both size of tumour as T and axillary lymphadenopathy
as N form an integral part of TNM staging and are of paramount
importance for their role in treatment decisions and illustrate
prognosis in patients with invasive breast cancer. |
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| ISSN: | 2249-782X 0973-709X |