The therapeutic potential of probucol and probucol analogues in neurodegenerative diseases

The therapeutic potential of probucol and probucol analogues in neurodegenerative diseases

Abstract Neurodegenerative disorders present complex pathologies characterized by various interconnected factors, including the aggregation of misfolded proteins, oxidative stress, neuroinflammation and compromised blood–brain barrier (BBB) integrity. Addressing such multifaceted pathways necessitat...

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Bibliographic Details
Main Authors: Arazu Sharif, John Mamo, Virginie Lam, Hani Al-Salami, Armin Mooranian, Gerald F. Watts, Roger Clarnette, Giuseppe Luna, Ryu Takechi
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Translational Neurodegeneration
Subjects:
Neurodegenerative disease
Probucol
Probucol analogues
Inflammation
Blood–brain barrier
Oxidative stress
Online Access:https://doi.org/10.1186/s40035-024-00398-w

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