Autophagy regulates Notch degradation and modulates stem cell development and neurogenesis
The molecular mechanisms behind how autophagy may impact on developmental pathways and cell fate decisions are unclear. Here Wu et al.identify Notch receptors being taken up into ATG16L1-positive autophagosomes and, using a mouse mutant model, show that changes in autophagy can impact on stem cell f...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2016-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms10533 |
| _version_ | 1818341752994529280 |
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| author | Xiaoting Wu Angeleen Fleming Thomas Ricketts Mariana Pavel Herbert Virgin Fiona M. Menzies David C. Rubinsztein |
| author_facet | Xiaoting Wu Angeleen Fleming Thomas Ricketts Mariana Pavel Herbert Virgin Fiona M. Menzies David C. Rubinsztein |
| author_sort | Xiaoting Wu |
| collection | DOAJ |
| description | The molecular mechanisms behind how autophagy may impact on developmental pathways and cell fate decisions are unclear. Here Wu et al.identify Notch receptors being taken up into ATG16L1-positive autophagosomes and, using a mouse mutant model, show that changes in autophagy can impact on stem cell fate. |
| first_indexed | 2024-12-13T16:03:48Z |
| format | Article |
| id | doaj.art-c71934f520734080a9c2a869599163df |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-13T16:03:48Z |
| publishDate | 2016-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-c71934f520734080a9c2a869599163df2022-12-21T23:39:05ZengNature PortfolioNature Communications2041-17232016-02-017111710.1038/ncomms10533Autophagy regulates Notch degradation and modulates stem cell development and neurogenesisXiaoting Wu0Angeleen Fleming1Thomas Ricketts2Mariana Pavel3Herbert Virgin4Fiona M. Menzies5David C. Rubinsztein6Department of Medical Genetics, Cambridge Institute for Medical Research (CIMR), University of CambridgeDepartment of Medical Genetics, Cambridge Institute for Medical Research (CIMR), University of CambridgeDepartment of Medical Genetics, Cambridge Institute for Medical Research (CIMR), University of CambridgeDepartment of Medical Genetics, Cambridge Institute for Medical Research (CIMR), University of CambridgeDepartment of Pathology and Immunology, Washington University School of MedicineDepartment of Medical Genetics, Cambridge Institute for Medical Research (CIMR), University of CambridgeDepartment of Medical Genetics, Cambridge Institute for Medical Research (CIMR), University of CambridgeThe molecular mechanisms behind how autophagy may impact on developmental pathways and cell fate decisions are unclear. Here Wu et al.identify Notch receptors being taken up into ATG16L1-positive autophagosomes and, using a mouse mutant model, show that changes in autophagy can impact on stem cell fate.https://doi.org/10.1038/ncomms10533 |
| spellingShingle | Xiaoting Wu Angeleen Fleming Thomas Ricketts Mariana Pavel Herbert Virgin Fiona M. Menzies David C. Rubinsztein Autophagy regulates Notch degradation and modulates stem cell development and neurogenesis Nature Communications |
| title | Autophagy regulates Notch degradation and modulates stem cell development and neurogenesis |
| title_full | Autophagy regulates Notch degradation and modulates stem cell development and neurogenesis |
| title_fullStr | Autophagy regulates Notch degradation and modulates stem cell development and neurogenesis |
| title_full_unstemmed | Autophagy regulates Notch degradation and modulates stem cell development and neurogenesis |
| title_short | Autophagy regulates Notch degradation and modulates stem cell development and neurogenesis |
| title_sort | autophagy regulates notch degradation and modulates stem cell development and neurogenesis |
| url | https://doi.org/10.1038/ncomms10533 |
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