Investigation of the Mechanisms of Cytotoxic Activity of 1,3-Disubstituted Thiourea Derivatives

Investigation of the Mechanisms of Cytotoxic Activity of 1,3-Disubstituted Thiourea Derivatives

Substituted thiourea derivatives possess confirmed cytotoxic activity towards cancer but also normal cells. To develop new selective antitumor agents, a series of 3-(trifluoromethyl)phenylthiourea analogs were synthesized, and their cytotoxicity was evaluated in vitro against the cell line panel. Co...

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Bibliographic Details
Main Authors: Paulina Strzyga-Łach, Alicja Chrzanowska, Katarzyna Podsadni, Anna Bielenica
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Pharmaceuticals
Subjects:
thiourea
cytotoxic activity
apoptosis
interleukin-6
trypan blue assay
Online Access:https://www.mdpi.com/1424-8247/14/11/1097

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