Metoclopramide versus Serum Therapy in the Control of Vomiting due to Acute Viral Gastroenteritis in Children: A Single-blind Randomized Clinical Trial
Background: Acute gastroenteritis in pediatric patients entails high rates of morbidity and mortality. One of its complications is dehydration, which should be managed carefully. We evaluated the efficacy of metoclopramide in the control of vomiting in children with acute viral gastroenteritis and m...
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| Format: | Article |
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Isfahan University of Medical Sciences
2012-12-01
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| Series: | مجله دانشکده پزشکی اصفهان |
| Online Access: | http://jims.mui.ac.ir/index.php/jims/article/view/1997 |
| _version_ | 1827846672526344192 |
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| author | Parsa Yousefi Mohammadreza Firouzifar Fatemeh Motaghedi |
| author_facet | Parsa Yousefi Mohammadreza Firouzifar Fatemeh Motaghedi |
| author_sort | Parsa Yousefi |
| collection | DOAJ |
| description | Background: Acute gastroenteritis in pediatric patients entails high rates of morbidity and mortality. One of its complications is dehydration, which should be managed carefully. We evaluated the efficacy of metoclopramide in the control of vomiting in children with acute viral gastroenteritis and moderate dehydration.
Methods: In this single-blind randomized clinical trial, we randomly assigned children aged 1-7 years with vomiting due to acute viral gastroenteritis to two groups of serum therapy (control) and metoclopramide (intervention). The control group received 5% dextrose water solution along with electrolyte management while the intervention group, in addition to the standard treatment, received 0.1 mg/kg metoclopramide intravenously. Patients were followed for 4 days for the number of vomiting episodes.
Findings: 240 children were studied in intervention and control groups (120 in each group). The mean number of vomiting episodes was significantly lower in metoclopramide-assigned patients in all 4 days of the follow up period (P = 0.021, P = 0.007, P = 0.002, and P = 0.001, respectively for day 1 to 4).
Conclusion: Although metoclopramide have shown effectiveness in the treatment of vomiting due to acute gastroenteritis, it is suggested performing multicenter studies comparing this drug with other common anti-emetics to allow for a better judgment.
Keywords: Gastroenteritis, Vomiting, Dehydration, Metoclopramide, Child |
| first_indexed | 2024-03-12T09:19:30Z |
| format | Article |
| id | doaj.art-c71a82cfc28045b09a16d4ac9006609f |
| institution | Directory Open Access Journal |
| issn | 1027-7595 1735-854X |
| language | fas |
| last_indexed | 2024-03-12T09:19:30Z |
| publishDate | 2012-12-01 |
| publisher | Isfahan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشکده پزشکی اصفهان |
| spelling | doaj.art-c71a82cfc28045b09a16d4ac9006609f2023-09-02T14:38:42ZfasIsfahan University of Medical Sciencesمجله دانشکده پزشکی اصفهان1027-75951735-854X2012-12-0130212182918381192Metoclopramide versus Serum Therapy in the Control of Vomiting due to Acute Viral Gastroenteritis in Children: A Single-blind Randomized Clinical TrialParsa Yousefi0Mohammadreza Firouzifar1Fatemeh Motaghedi2Assistant Professor, Department of Pediatrics, School of Medicine, Arak University of Medical Sciences, Arak, IranStudent of Medicine, Student Research Committee, Arak University of Medical Sciences, Arak, IranStudent of Medicine, Student Research Committee, Arak University of Medical Sciences, Arak, IranBackground: Acute gastroenteritis in pediatric patients entails high rates of morbidity and mortality. One of its complications is dehydration, which should be managed carefully. We evaluated the efficacy of metoclopramide in the control of vomiting in children with acute viral gastroenteritis and moderate dehydration. Methods: In this single-blind randomized clinical trial, we randomly assigned children aged 1-7 years with vomiting due to acute viral gastroenteritis to two groups of serum therapy (control) and metoclopramide (intervention). The control group received 5% dextrose water solution along with electrolyte management while the intervention group, in addition to the standard treatment, received 0.1 mg/kg metoclopramide intravenously. Patients were followed for 4 days for the number of vomiting episodes. Findings: 240 children were studied in intervention and control groups (120 in each group). The mean number of vomiting episodes was significantly lower in metoclopramide-assigned patients in all 4 days of the follow up period (P = 0.021, P = 0.007, P = 0.002, and P = 0.001, respectively for day 1 to 4). Conclusion: Although metoclopramide have shown effectiveness in the treatment of vomiting due to acute gastroenteritis, it is suggested performing multicenter studies comparing this drug with other common anti-emetics to allow for a better judgment. Keywords: Gastroenteritis, Vomiting, Dehydration, Metoclopramide, Childhttp://jims.mui.ac.ir/index.php/jims/article/view/1997 |
| spellingShingle | Parsa Yousefi Mohammadreza Firouzifar Fatemeh Motaghedi Metoclopramide versus Serum Therapy in the Control of Vomiting due to Acute Viral Gastroenteritis in Children: A Single-blind Randomized Clinical Trial مجله دانشکده پزشکی اصفهان |
| title | Metoclopramide versus Serum Therapy in the Control of Vomiting due to Acute Viral Gastroenteritis in Children: A Single-blind Randomized Clinical Trial |
| title_full | Metoclopramide versus Serum Therapy in the Control of Vomiting due to Acute Viral Gastroenteritis in Children: A Single-blind Randomized Clinical Trial |
| title_fullStr | Metoclopramide versus Serum Therapy in the Control of Vomiting due to Acute Viral Gastroenteritis in Children: A Single-blind Randomized Clinical Trial |
| title_full_unstemmed | Metoclopramide versus Serum Therapy in the Control of Vomiting due to Acute Viral Gastroenteritis in Children: A Single-blind Randomized Clinical Trial |
| title_short | Metoclopramide versus Serum Therapy in the Control of Vomiting due to Acute Viral Gastroenteritis in Children: A Single-blind Randomized Clinical Trial |
| title_sort | metoclopramide versus serum therapy in the control of vomiting due to acute viral gastroenteritis in children a single blind randomized clinical trial |
| url | http://jims.mui.ac.ir/index.php/jims/article/view/1997 |
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