Exposure to polycyclic aromatic hydrocarbons in women living in the Chinese cities of BaoDing and Dalian revealed by hair analysis

Polycyclic aromatic hydrocarbons (PAH) are produced from incomplete combustion of organic matter and released as environmental contaminants from activities such as transports, wood combustion, coal-fired power plants. In numerous urban areas worldwide, the levels of PAH exposure are considered criti...

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Main Authors: Paul Palazzi, Sakina Mezzache, Nasrine Bourokba, Emilie M. Hardy, Anna Schritz, Philippe Bastien, Claude Emond, Jing Li, Jeremie Soeur, Brice M.R. Appenzeller
Format: Article
Language:English
Published: Elsevier 2018-12-01
Series:Environment International
Online Access:http://www.sciencedirect.com/science/article/pii/S016041201831496X
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author Paul Palazzi
Sakina Mezzache
Nasrine Bourokba
Emilie M. Hardy
Anna Schritz
Philippe Bastien
Claude Emond
Jing Li
Jeremie Soeur
Brice M.R. Appenzeller
author_facet Paul Palazzi
Sakina Mezzache
Nasrine Bourokba
Emilie M. Hardy
Anna Schritz
Philippe Bastien
Claude Emond
Jing Li
Jeremie Soeur
Brice M.R. Appenzeller
author_sort Paul Palazzi
collection DOAJ
description Polycyclic aromatic hydrocarbons (PAH) are produced from incomplete combustion of organic matter and released as environmental contaminants from activities such as transports, wood combustion, coal-fired power plants. In numerous urban areas worldwide, the levels of PAH exposure are considered critical regarding public health issues. The possibility to detect PAH and PAH metabolites biologically incorporated in human hair was demonstrated and proposed as biomarkers of exposure. Nevertheless, the possibility to distinguish different levels of exposure between different populations is still needed to validate the relevance of hair analysis in epidemiological studies. In this work, hair samples were collected from 204 women from two cities in China based on one year Air Quality Index history from governmental data (Baoding as polluted city and Dalian less polluted city). 8 out of the 15 parent PAH and 7 out of the 56 metabolites analyzed in this study were detected in all the samples. The highest concentrations in hair were observed for phenanthrene (4.2 to 889 pg/mg) > fluoranthene (1.05 to 204 pg/mg) > pyrene (3.2 to 124 pg/mg) for parent PAH, and for 9-OH-fluorene (0.04 to 1.78 pg/mg) > 2-OH-naphthalene (0.68 to 811 pg/mg) > 1-OH-anthracene (0.24 to 10.9 pg/mg) for metabolites. 14 parent PAH and 15 metabolites presented a significantly higher concentration in the hair samples collected from Baoding, as compared to Dalian. The median concentration of parent PAH was from 1.5 to 2.8 times higher in the hair of the subjects from Baoding than in subjects from Dalian and that of PAH metabolites was from 1 to 2.3 times higher. The study of inter-chemical associations revealed similarities and differences between the two areas, suggesting common and different sources of exposure depending on PAH respectively. The results confirmed the relevance of hair analysis to identify qualitative and quantitative differences in PAH exposure between populations from different areas. This study is the first one to investigate both parent PAH and their metabolites in a biological matrix. Keywords: Polycyclic aromatic hydrocarbons, Hair analysis, Cumulative exposure, Environmental exposure, Biomarkers
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spelling doaj.art-c71b555f62814f22aba9d4e6f8ac2f272022-12-21T23:25:43ZengElsevierEnvironment International0160-41202018-12-0112113411354Exposure to polycyclic aromatic hydrocarbons in women living in the Chinese cities of BaoDing and Dalian revealed by hair analysisPaul Palazzi0Sakina Mezzache1Nasrine Bourokba2Emilie M. Hardy3Anna Schritz4Philippe Bastien5Claude Emond6Jing Li7Jeremie Soeur8Brice M.R. Appenzeller9Human Biomonitoring Research Unit, Department of Population Health, Luxembourg Institute of Health, 1 A-B rue Thomas Edison, 1445 Strassen, LuxembourgL'Oréal Research and Innovation, 1 avenue Eugène Schueller BP22, 93601 Aulnay sous Bois, FranceL'Oréal Research and Innovation, Biopolis Drive, Synapse, 138623, SingaporeHuman Biomonitoring Research Unit, Department of Population Health, Luxembourg Institute of Health, 1 A-B rue Thomas Edison, 1445 Strassen, LuxembourgCompetence Center for Methodology and Statistics, Department of Population Health, Luxembourg Institute of Health, 1 A-B rue Thomas Edison, 1445 Strassen, LuxembourgL'Oréal Research and Innovation, 1 avenue Eugène Schueller BP22, 93601 Aulnay sous Bois, FranceHuman Biomonitoring Research Unit, Department of Population Health, Luxembourg Institute of Health, 1 A-B rue Thomas Edison, 1445 Strassen, LuxembourgL'Oréal Research and Innovation, No. 550 JinYu Rd., Pudong New Area, ChinaL'Oréal Research and Innovation, 1 avenue Eugène Schueller BP22, 93601 Aulnay sous Bois, FranceHuman Biomonitoring Research Unit, Department of Population Health, Luxembourg Institute of Health, 1 A-B rue Thomas Edison, 1445 Strassen, Luxembourg; Corresponding author.Polycyclic aromatic hydrocarbons (PAH) are produced from incomplete combustion of organic matter and released as environmental contaminants from activities such as transports, wood combustion, coal-fired power plants. In numerous urban areas worldwide, the levels of PAH exposure are considered critical regarding public health issues. The possibility to detect PAH and PAH metabolites biologically incorporated in human hair was demonstrated and proposed as biomarkers of exposure. Nevertheless, the possibility to distinguish different levels of exposure between different populations is still needed to validate the relevance of hair analysis in epidemiological studies. In this work, hair samples were collected from 204 women from two cities in China based on one year Air Quality Index history from governmental data (Baoding as polluted city and Dalian less polluted city). 8 out of the 15 parent PAH and 7 out of the 56 metabolites analyzed in this study were detected in all the samples. The highest concentrations in hair were observed for phenanthrene (4.2 to 889 pg/mg) > fluoranthene (1.05 to 204 pg/mg) > pyrene (3.2 to 124 pg/mg) for parent PAH, and for 9-OH-fluorene (0.04 to 1.78 pg/mg) > 2-OH-naphthalene (0.68 to 811 pg/mg) > 1-OH-anthracene (0.24 to 10.9 pg/mg) for metabolites. 14 parent PAH and 15 metabolites presented a significantly higher concentration in the hair samples collected from Baoding, as compared to Dalian. The median concentration of parent PAH was from 1.5 to 2.8 times higher in the hair of the subjects from Baoding than in subjects from Dalian and that of PAH metabolites was from 1 to 2.3 times higher. The study of inter-chemical associations revealed similarities and differences between the two areas, suggesting common and different sources of exposure depending on PAH respectively. The results confirmed the relevance of hair analysis to identify qualitative and quantitative differences in PAH exposure between populations from different areas. This study is the first one to investigate both parent PAH and their metabolites in a biological matrix. Keywords: Polycyclic aromatic hydrocarbons, Hair analysis, Cumulative exposure, Environmental exposure, Biomarkershttp://www.sciencedirect.com/science/article/pii/S016041201831496X
spellingShingle Paul Palazzi
Sakina Mezzache
Nasrine Bourokba
Emilie M. Hardy
Anna Schritz
Philippe Bastien
Claude Emond
Jing Li
Jeremie Soeur
Brice M.R. Appenzeller
Exposure to polycyclic aromatic hydrocarbons in women living in the Chinese cities of BaoDing and Dalian revealed by hair analysis
Environment International
title Exposure to polycyclic aromatic hydrocarbons in women living in the Chinese cities of BaoDing and Dalian revealed by hair analysis
title_full Exposure to polycyclic aromatic hydrocarbons in women living in the Chinese cities of BaoDing and Dalian revealed by hair analysis
title_fullStr Exposure to polycyclic aromatic hydrocarbons in women living in the Chinese cities of BaoDing and Dalian revealed by hair analysis
title_full_unstemmed Exposure to polycyclic aromatic hydrocarbons in women living in the Chinese cities of BaoDing and Dalian revealed by hair analysis
title_short Exposure to polycyclic aromatic hydrocarbons in women living in the Chinese cities of BaoDing and Dalian revealed by hair analysis
title_sort exposure to polycyclic aromatic hydrocarbons in women living in the chinese cities of baoding and dalian revealed by hair analysis
url http://www.sciencedirect.com/science/article/pii/S016041201831496X
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