Preserved performance monitoring and error detection in left hemisphere stroke
Depending on the lesion site, a stroke typically affects various aspects of cognitive control. While executing a task, the performance monitoring system constantly compares an intended action plan with the executed action and thereby registers inaccurate actions in case of any mismatch. When errors...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-01-01
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| Series: | NeuroImage: Clinical |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158220301443 |
| _version_ | 1818260798718345216 |
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| author | Eva Niessen Jana M. Ant Stefan Bode Jochen Saliger Hans Karbe Gereon R. Fink Jutta Stahl Peter H. Weiss |
| author_facet | Eva Niessen Jana M. Ant Stefan Bode Jochen Saliger Hans Karbe Gereon R. Fink Jutta Stahl Peter H. Weiss |
| author_sort | Eva Niessen |
| collection | DOAJ |
| description | Depending on the lesion site, a stroke typically affects various aspects of cognitive control. While executing a task, the performance monitoring system constantly compares an intended action plan with the executed action and thereby registers inaccurate actions in case of any mismatch. When errors occur, the performance monitoring system signals the need for more cognitive control, which is most efficient when the subject notices errors rather than processing them subconsciously. The current study aimed to investigate performance monitoring and error detection in a large sample of patients with left hemisphere (LH) stroke.In addition to clinical and neuropsychological tests, 24 LH stroke patients and 32 healthy age-matched controls performed a Go/Nogo task with simultaneous electroencephalography (EEG) measurements. This set-up enabled us to compare performance monitoring at the behavioral and the neural level. EEG data were analyzed using event-related potentials [ERPs; e.g., the error-related negativity (Ne/ERN) and error positivity (Pe)] and additionally more sensitive whole-brain multivariate pattern classification analyses (MVPA). We hypothesized that LH stroke patients would show behavioural deficits in error detection when compared to healthy controls, mirrored by differences in neural signals, in particular reflected in the Pe component.Interestingly, despite clinically relevant cognitive deficits (e.g., aphasia and apraxia) including executive dysfunction (trail making test), we did not observe any behavioral impairments related to performance monitoring and error processing in the current LH stroke patients. Patients also showed similar results for Ne/ERN and Pe components, compared to the control group, and a highly similar prediction of errors from multivariate signals. ERP abnormalities during stimulus processing (i.e., N2 and P3) demonstrated the specificity of these findings in the current LH stroke patients. In contrast to previous studies, by employing a relatively large patient sample, a well-controlled experimental paradigm with a standardized error signaling procedure, and advanced data analysis, we were able to show that performance monitoring (of simple actions) is a preserved cognitive control function in LH stroke patients that might constitute a useful resource in rehabilitative therapies for re-learning impeded functions. |
| first_indexed | 2024-12-12T18:37:04Z |
| format | Article |
| id | doaj.art-c71b806c1fcc4eaa97849a9d5bba1c54 |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-12-12T18:37:04Z |
| publishDate | 2020-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-c71b806c1fcc4eaa97849a9d5bba1c542022-12-22T00:15:45ZengElsevierNeuroImage: Clinical2213-15822020-01-0127102307Preserved performance monitoring and error detection in left hemisphere strokeEva Niessen0Jana M. Ant1Stefan Bode2Jochen Saliger3Hans Karbe4Gereon R. Fink5Jutta Stahl6Peter H. Weiss7Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM-3), Research Centre Jülich, Germany; Corresponding author at: Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM-3), Research Centre Jülich, 52425 Jülich, Germany.University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Neurology, GermanyMelbourne School of Psychological Sciences, University of Melbourne, Australia; Department of Individual Differences and Psychological Assessment, University of Cologne, GermanyNeurological Rehabilitation Centre Godeshöhe, GermanyNeurological Rehabilitation Centre Godeshöhe, GermanyCognitive Neuroscience, Institute of Neuroscience and Medicine (INM-3), Research Centre Jülich, Germany; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Neurology, GermanyDepartment of Individual Differences and Psychological Assessment, University of Cologne, GermanyCognitive Neuroscience, Institute of Neuroscience and Medicine (INM-3), Research Centre Jülich, Germany; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Neurology, GermanyDepending on the lesion site, a stroke typically affects various aspects of cognitive control. While executing a task, the performance monitoring system constantly compares an intended action plan with the executed action and thereby registers inaccurate actions in case of any mismatch. When errors occur, the performance monitoring system signals the need for more cognitive control, which is most efficient when the subject notices errors rather than processing them subconsciously. The current study aimed to investigate performance monitoring and error detection in a large sample of patients with left hemisphere (LH) stroke.In addition to clinical and neuropsychological tests, 24 LH stroke patients and 32 healthy age-matched controls performed a Go/Nogo task with simultaneous electroencephalography (EEG) measurements. This set-up enabled us to compare performance monitoring at the behavioral and the neural level. EEG data were analyzed using event-related potentials [ERPs; e.g., the error-related negativity (Ne/ERN) and error positivity (Pe)] and additionally more sensitive whole-brain multivariate pattern classification analyses (MVPA). We hypothesized that LH stroke patients would show behavioural deficits in error detection when compared to healthy controls, mirrored by differences in neural signals, in particular reflected in the Pe component.Interestingly, despite clinically relevant cognitive deficits (e.g., aphasia and apraxia) including executive dysfunction (trail making test), we did not observe any behavioral impairments related to performance monitoring and error processing in the current LH stroke patients. Patients also showed similar results for Ne/ERN and Pe components, compared to the control group, and a highly similar prediction of errors from multivariate signals. ERP abnormalities during stimulus processing (i.e., N2 and P3) demonstrated the specificity of these findings in the current LH stroke patients. In contrast to previous studies, by employing a relatively large patient sample, a well-controlled experimental paradigm with a standardized error signaling procedure, and advanced data analysis, we were able to show that performance monitoring (of simple actions) is a preserved cognitive control function in LH stroke patients that might constitute a useful resource in rehabilitative therapies for re-learning impeded functions.http://www.sciencedirect.com/science/article/pii/S2213158220301443StrokeCognitive controlEEGMultivariate pattern analysisEvent-related potentials |
| spellingShingle | Eva Niessen Jana M. Ant Stefan Bode Jochen Saliger Hans Karbe Gereon R. Fink Jutta Stahl Peter H. Weiss Preserved performance monitoring and error detection in left hemisphere stroke NeuroImage: Clinical Stroke Cognitive control EEG Multivariate pattern analysis Event-related potentials |
| title | Preserved performance monitoring and error detection in left hemisphere stroke |
| title_full | Preserved performance monitoring and error detection in left hemisphere stroke |
| title_fullStr | Preserved performance monitoring and error detection in left hemisphere stroke |
| title_full_unstemmed | Preserved performance monitoring and error detection in left hemisphere stroke |
| title_short | Preserved performance monitoring and error detection in left hemisphere stroke |
| title_sort | preserved performance monitoring and error detection in left hemisphere stroke |
| topic | Stroke Cognitive control EEG Multivariate pattern analysis Event-related potentials |
| url | http://www.sciencedirect.com/science/article/pii/S2213158220301443 |
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