Analysis of the risk of future gastrointestinal surgery in Crohn's disease with stricture
Background: Stricture in patients with Crohn's disease (CD) carries a high risk of CD-related surgery in the course of the disease. The aim of this study was to assess the rate of occurrence of CD-related surgery and to determine baseline risk factors predicting subsequent surgery in this patie...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2024-01-01
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| Series: | The Saudi Journal of Gastroenterology |
| Subjects: | |
| Online Access: | http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2024;volume=30;issue=2;spage=108;epage=113;aulast=Zeng |
| _version_ | 1797221653523988480 |
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| author | Wen Zeng Yong Chen Bolong Yin Xue Wen Jian Xiao Lian Luo Haiyuan Tang He Zheng |
| author_facet | Wen Zeng Yong Chen Bolong Yin Xue Wen Jian Xiao Lian Luo Haiyuan Tang He Zheng |
| author_sort | Wen Zeng |
| collection | DOAJ |
| description | Background: Stricture in patients with Crohn's disease (CD) carries a high risk of CD-related surgery in the course of the disease. The aim of this study was to assess the rate of occurrence of CD-related surgery and to determine baseline risk factors predicting subsequent surgery in this patient group.
Methods: Patients registered with stricturing CD were included. All baseline and follow-up data were collected retrospectively. Patients attended the clinic for follow-up at week 14 to assess their response to infliximab (IFX). CD-related surgery was the observational endpoint. Univariate and multivariate Cox regression analyses were used.
Results: A total of 123 patients with stricturing CD were included in this study. The cumulative risk of CD-related surgery for years 1–5 after diagnosis was 18.0%, 26.7%, 32.6%, 40.7%, and 46.4%, respectively. Prior gastrointestinal (GI) surgery, low body mass index (BMI), and high platelet count might be risk factors for future CD-related surgery. With 97 participants treated by IFX, prior GI surgery and primary non-response (PNR) to IFX correlated with future CD-related surgery.
Conclusion: Prior GI surgery, BMI, and platelet counts were related to future CD-related surgery. Patients who were PNR to IFX had a higher risk of CD-related surgery in the future. |
| first_indexed | 2024-04-24T13:08:51Z |
| format | Article |
| id | doaj.art-c71fc853c145420d85b12cee62dd3540 |
| institution | Directory Open Access Journal |
| issn | 1319-3767 1998-4049 |
| language | English |
| last_indexed | 2024-04-24T13:08:51Z |
| publishDate | 2024-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | The Saudi Journal of Gastroenterology |
| spelling | doaj.art-c71fc853c145420d85b12cee62dd35402024-04-05T05:29:04ZengWolters Kluwer Medknow PublicationsThe Saudi Journal of Gastroenterology1319-37671998-40492024-01-0130210811310.4103/sjg.sjg_256_23Analysis of the risk of future gastrointestinal surgery in Crohn's disease with strictureWen ZengYong ChenBolong YinXue WenJian XiaoLian LuoHaiyuan TangHe ZhengBackground: Stricture in patients with Crohn's disease (CD) carries a high risk of CD-related surgery in the course of the disease. The aim of this study was to assess the rate of occurrence of CD-related surgery and to determine baseline risk factors predicting subsequent surgery in this patient group. Methods: Patients registered with stricturing CD were included. All baseline and follow-up data were collected retrospectively. Patients attended the clinic for follow-up at week 14 to assess their response to infliximab (IFX). CD-related surgery was the observational endpoint. Univariate and multivariate Cox regression analyses were used. Results: A total of 123 patients with stricturing CD were included in this study. The cumulative risk of CD-related surgery for years 1–5 after diagnosis was 18.0%, 26.7%, 32.6%, 40.7%, and 46.4%, respectively. Prior gastrointestinal (GI) surgery, low body mass index (BMI), and high platelet count might be risk factors for future CD-related surgery. With 97 participants treated by IFX, prior GI surgery and primary non-response (PNR) to IFX correlated with future CD-related surgery. Conclusion: Prior GI surgery, BMI, and platelet counts were related to future CD-related surgery. Patients who were PNR to IFX had a higher risk of CD-related surgery in the future.http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2024;volume=30;issue=2;spage=108;epage=113;aulast=Zengcrohn's diseasestricturesurgery |
| spellingShingle | Wen Zeng Yong Chen Bolong Yin Xue Wen Jian Xiao Lian Luo Haiyuan Tang He Zheng Analysis of the risk of future gastrointestinal surgery in Crohn's disease with stricture The Saudi Journal of Gastroenterology crohn's disease stricture surgery |
| title | Analysis of the risk of future gastrointestinal surgery in Crohn's disease with stricture |
| title_full | Analysis of the risk of future gastrointestinal surgery in Crohn's disease with stricture |
| title_fullStr | Analysis of the risk of future gastrointestinal surgery in Crohn's disease with stricture |
| title_full_unstemmed | Analysis of the risk of future gastrointestinal surgery in Crohn's disease with stricture |
| title_short | Analysis of the risk of future gastrointestinal surgery in Crohn's disease with stricture |
| title_sort | analysis of the risk of future gastrointestinal surgery in crohn s disease with stricture |
| topic | crohn's disease stricture surgery |
| url | http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2024;volume=30;issue=2;spage=108;epage=113;aulast=Zeng |
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