Left Ventricular Non-Compaction Spectrum in Adults and Children: From a Morphological Trait to a Structural Muscular Disease
Left ventricular non-compaction (LVNC) is an extremely heterogeneous disorder with a highly variable clinical presentation, morphologic appearance at imaging testing, and prognosis. It is still unclear whether LVNC should be classified as a separate cardiomyopathy or if it is a mere morphological tr...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Cardiogenetics |
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| Online Access: | https://www.mdpi.com/2035-8148/12/2/16 |
| _version_ | 1797489083455373312 |
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| author | Flavia Fusco Nunzia Borrelli Rosaria Barracano Giovanni Domenico Ciriello Federica Verrillo Giancarlo Scognamiglio Berardo Sarubbi |
| author_facet | Flavia Fusco Nunzia Borrelli Rosaria Barracano Giovanni Domenico Ciriello Federica Verrillo Giancarlo Scognamiglio Berardo Sarubbi |
| author_sort | Flavia Fusco |
| collection | DOAJ |
| description | Left ventricular non-compaction (LVNC) is an extremely heterogeneous disorder with a highly variable clinical presentation, morphologic appearance at imaging testing, and prognosis. It is still unclear whether LVNC should be classified as a separate cardiomyopathy or if it is a mere morphological trait shared by many phenotypically distinct cardiomyopathies. Moreover, the hypertrabeculated phenotype may be reversible in some cases, possibly reflecting the left ventricular physiological response of the cardiac muscle to chronic overload. The current diagnostic criteria have several limitations, leaving many patients in a grey area. Here, we review the available literature on LVNC in order to provide an overview of the current knowledge on this complex disorder. |
| first_indexed | 2024-03-10T00:12:26Z |
| format | Article |
| id | doaj.art-c721133f872e4b5c917148ee65ec7e69 |
| institution | Directory Open Access Journal |
| issn | 2035-8253 2035-8148 |
| language | English |
| last_indexed | 2024-03-10T00:12:26Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cardiogenetics |
| spelling | doaj.art-c721133f872e4b5c917148ee65ec7e692023-11-23T15:58:37ZengMDPI AGCardiogenetics2035-82532035-81482022-04-0112217018410.3390/cardiogenetics12020016Left Ventricular Non-Compaction Spectrum in Adults and Children: From a Morphological Trait to a Structural Muscular DiseaseFlavia Fusco0Nunzia Borrelli1Rosaria Barracano2Giovanni Domenico Ciriello3Federica Verrillo4Giancarlo Scognamiglio5Berardo Sarubbi6Adult Congenital Heart Disease Unit, AO dei Colli—Monaldi Hospital, 80131 Naples, ItalyAdult Congenital Heart Disease Unit, AO dei Colli—Monaldi Hospital, 80131 Naples, ItalyAdult Congenital Heart Disease Unit, AO dei Colli—Monaldi Hospital, 80131 Naples, ItalyAdult Congenital Heart Disease Unit, AO dei Colli—Monaldi Hospital, 80131 Naples, ItalyInherited and Rare Cardiovascular Diseases, Department of Translational Medical Sciences, University of Campania Luigi Vanvitelli, Monaldi Hospital, 80131 Naples, ItalyAdult Congenital Heart Disease Unit, AO dei Colli—Monaldi Hospital, 80131 Naples, ItalyAdult Congenital Heart Disease Unit, AO dei Colli—Monaldi Hospital, 80131 Naples, ItalyLeft ventricular non-compaction (LVNC) is an extremely heterogeneous disorder with a highly variable clinical presentation, morphologic appearance at imaging testing, and prognosis. It is still unclear whether LVNC should be classified as a separate cardiomyopathy or if it is a mere morphological trait shared by many phenotypically distinct cardiomyopathies. Moreover, the hypertrabeculated phenotype may be reversible in some cases, possibly reflecting the left ventricular physiological response of the cardiac muscle to chronic overload. The current diagnostic criteria have several limitations, leaving many patients in a grey area. Here, we review the available literature on LVNC in order to provide an overview of the current knowledge on this complex disorder.https://www.mdpi.com/2035-8148/12/2/16left ventricular non-compactionLVNChypertrabeculated left ventriclecardiomyopathyreversible |
| spellingShingle | Flavia Fusco Nunzia Borrelli Rosaria Barracano Giovanni Domenico Ciriello Federica Verrillo Giancarlo Scognamiglio Berardo Sarubbi Left Ventricular Non-Compaction Spectrum in Adults and Children: From a Morphological Trait to a Structural Muscular Disease Cardiogenetics left ventricular non-compaction LVNC hypertrabeculated left ventricle cardiomyopathy reversible |
| title | Left Ventricular Non-Compaction Spectrum in Adults and Children: From a Morphological Trait to a Structural Muscular Disease |
| title_full | Left Ventricular Non-Compaction Spectrum in Adults and Children: From a Morphological Trait to a Structural Muscular Disease |
| title_fullStr | Left Ventricular Non-Compaction Spectrum in Adults and Children: From a Morphological Trait to a Structural Muscular Disease |
| title_full_unstemmed | Left Ventricular Non-Compaction Spectrum in Adults and Children: From a Morphological Trait to a Structural Muscular Disease |
| title_short | Left Ventricular Non-Compaction Spectrum in Adults and Children: From a Morphological Trait to a Structural Muscular Disease |
| title_sort | left ventricular non compaction spectrum in adults and children from a morphological trait to a structural muscular disease |
| topic | left ventricular non-compaction LVNC hypertrabeculated left ventricle cardiomyopathy reversible |
| url | https://www.mdpi.com/2035-8148/12/2/16 |
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