THE USE OF HAMMETT CONSTANTS TO UNDERSTAND THE NON-COVALENT BINDING OF AROMATICS
Non-covalent interactions of aromatics are important in a wide range of chemical and biological applications. The past two decades have seen numerous reports of arene-arene binding being understood in terms Hammett substituent constants, and similar analyses have recently been extended to cation-are...
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Elsevier
2012-04-01
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Series: | Computational and Structural Biotechnology Journal |
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Online Access: | http://www.sciencedirect.com/science/article/pii/S2001037014601069 |
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author | Michael Lewis Christina Bagwill Laura K.E. Hardebeck Selina Wireduaah |
author_facet | Michael Lewis Christina Bagwill Laura K.E. Hardebeck Selina Wireduaah |
author_sort | Michael Lewis |
collection | DOAJ |
description | Non-covalent interactions of aromatics are important in a wide range of chemical and biological applications. The past two decades have seen numerous reports of arene-arene binding being understood in terms Hammett substituent constants, and similar analyses have recently been extended to cation-arene and anion-arene binding. It is not immediately clear why electrostatic Hammett parameters should work so well in predicting the binding for all three interactions, given that different intermolecular forces dominate each interaction. This review explores such anomalies, and summarizes how Hammett substituent constants have been employed to understand the non-covalent binding in arene-arene, cation-arene and anion-arene interactions. |
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id | doaj.art-c721861c93b14d97b81cc68fd79a08ae |
institution | Directory Open Access Journal |
issn | 2001-0370 |
language | English |
last_indexed | 2024-04-12T23:08:28Z |
publishDate | 2012-04-01 |
publisher | Elsevier |
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series | Computational and Structural Biotechnology Journal |
spelling | doaj.art-c721861c93b14d97b81cc68fd79a08ae2022-12-22T03:12:52ZengElsevierComputational and Structural Biotechnology Journal2001-03702012-04-011110.5936/csbj.201204004THE USE OF HAMMETT CONSTANTS TO UNDERSTAND THE NON-COVALENT BINDING OF AROMATICSMichael Lewis0Christina Bagwill1Laura K.E. Hardebeck2Selina Wireduaah3Saint Louis University, 3501 Laclede Avenue, Saint Louis, Missouri, USA 63130Saint Louis University, 3501 Laclede Avenue, Saint Louis, Missouri, USA 63130Saint Louis University, 3501 Laclede Avenue, Saint Louis, Missouri, USA 63130Saint Louis University, 3501 Laclede Avenue, Saint Louis, Missouri, USA 63130Non-covalent interactions of aromatics are important in a wide range of chemical and biological applications. The past two decades have seen numerous reports of arene-arene binding being understood in terms Hammett substituent constants, and similar analyses have recently been extended to cation-arene and anion-arene binding. It is not immediately clear why electrostatic Hammett parameters should work so well in predicting the binding for all three interactions, given that different intermolecular forces dominate each interaction. This review explores such anomalies, and summarizes how Hammett substituent constants have been employed to understand the non-covalent binding in arene-arene, cation-arene and anion-arene interactions.http://www.sciencedirect.com/science/article/pii/S2001037014601069Hammett ConstantsArene-Arene InteractionsCation-Arene InteractionsAromatics |
spellingShingle | Michael Lewis Christina Bagwill Laura K.E. Hardebeck Selina Wireduaah THE USE OF HAMMETT CONSTANTS TO UNDERSTAND THE NON-COVALENT BINDING OF AROMATICS Computational and Structural Biotechnology Journal Hammett Constants Arene-Arene Interactions Cation-Arene Interactions Aromatics |
title | THE USE OF HAMMETT CONSTANTS TO UNDERSTAND THE NON-COVALENT BINDING OF AROMATICS |
title_full | THE USE OF HAMMETT CONSTANTS TO UNDERSTAND THE NON-COVALENT BINDING OF AROMATICS |
title_fullStr | THE USE OF HAMMETT CONSTANTS TO UNDERSTAND THE NON-COVALENT BINDING OF AROMATICS |
title_full_unstemmed | THE USE OF HAMMETT CONSTANTS TO UNDERSTAND THE NON-COVALENT BINDING OF AROMATICS |
title_short | THE USE OF HAMMETT CONSTANTS TO UNDERSTAND THE NON-COVALENT BINDING OF AROMATICS |
title_sort | use of hammett constants to understand the non covalent binding of aromatics |
topic | Hammett Constants Arene-Arene Interactions Cation-Arene Interactions Aromatics |
url | http://www.sciencedirect.com/science/article/pii/S2001037014601069 |
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