THE USE OF HAMMETT CONSTANTS TO UNDERSTAND THE NON-COVALENT BINDING OF AROMATICS

Non-covalent interactions of aromatics are important in a wide range of chemical and biological applications. The past two decades have seen numerous reports of arene-arene binding being understood in terms Hammett substituent constants, and similar analyses have recently been extended to cation-are...

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Main Authors: Michael Lewis, Christina Bagwill, Laura K.E. Hardebeck, Selina Wireduaah
Format: Article
Language:English
Published: Elsevier 2012-04-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037014601069
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author Michael Lewis
Christina Bagwill
Laura K.E. Hardebeck
Selina Wireduaah
author_facet Michael Lewis
Christina Bagwill
Laura K.E. Hardebeck
Selina Wireduaah
author_sort Michael Lewis
collection DOAJ
description Non-covalent interactions of aromatics are important in a wide range of chemical and biological applications. The past two decades have seen numerous reports of arene-arene binding being understood in terms Hammett substituent constants, and similar analyses have recently been extended to cation-arene and anion-arene binding. It is not immediately clear why electrostatic Hammett parameters should work so well in predicting the binding for all three interactions, given that different intermolecular forces dominate each interaction. This review explores such anomalies, and summarizes how Hammett substituent constants have been employed to understand the non-covalent binding in arene-arene, cation-arene and anion-arene interactions.
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spelling doaj.art-c721861c93b14d97b81cc68fd79a08ae2022-12-22T03:12:52ZengElsevierComputational and Structural Biotechnology Journal2001-03702012-04-011110.5936/csbj.201204004THE USE OF HAMMETT CONSTANTS TO UNDERSTAND THE NON-COVALENT BINDING OF AROMATICSMichael Lewis0Christina Bagwill1Laura K.E. Hardebeck2Selina Wireduaah3Saint Louis University, 3501 Laclede Avenue, Saint Louis, Missouri, USA 63130Saint Louis University, 3501 Laclede Avenue, Saint Louis, Missouri, USA 63130Saint Louis University, 3501 Laclede Avenue, Saint Louis, Missouri, USA 63130Saint Louis University, 3501 Laclede Avenue, Saint Louis, Missouri, USA 63130Non-covalent interactions of aromatics are important in a wide range of chemical and biological applications. The past two decades have seen numerous reports of arene-arene binding being understood in terms Hammett substituent constants, and similar analyses have recently been extended to cation-arene and anion-arene binding. It is not immediately clear why electrostatic Hammett parameters should work so well in predicting the binding for all three interactions, given that different intermolecular forces dominate each interaction. This review explores such anomalies, and summarizes how Hammett substituent constants have been employed to understand the non-covalent binding in arene-arene, cation-arene and anion-arene interactions.http://www.sciencedirect.com/science/article/pii/S2001037014601069Hammett ConstantsArene-Arene InteractionsCation-Arene InteractionsAromatics
spellingShingle Michael Lewis
Christina Bagwill
Laura K.E. Hardebeck
Selina Wireduaah
THE USE OF HAMMETT CONSTANTS TO UNDERSTAND THE NON-COVALENT BINDING OF AROMATICS
Computational and Structural Biotechnology Journal
Hammett Constants
Arene-Arene Interactions
Cation-Arene Interactions
Aromatics
title THE USE OF HAMMETT CONSTANTS TO UNDERSTAND THE NON-COVALENT BINDING OF AROMATICS
title_full THE USE OF HAMMETT CONSTANTS TO UNDERSTAND THE NON-COVALENT BINDING OF AROMATICS
title_fullStr THE USE OF HAMMETT CONSTANTS TO UNDERSTAND THE NON-COVALENT BINDING OF AROMATICS
title_full_unstemmed THE USE OF HAMMETT CONSTANTS TO UNDERSTAND THE NON-COVALENT BINDING OF AROMATICS
title_short THE USE OF HAMMETT CONSTANTS TO UNDERSTAND THE NON-COVALENT BINDING OF AROMATICS
title_sort use of hammett constants to understand the non covalent binding of aromatics
topic Hammett Constants
Arene-Arene Interactions
Cation-Arene Interactions
Aromatics
url http://www.sciencedirect.com/science/article/pii/S2001037014601069
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