A tale from TGF-β superfamily for thymus ontogeny and function
Multiple signaling pathways control every aspect of cell behavior, organ formation and tissue homeostasis throughout the lifespan of any individual. This review takes an ontogenetic view focused on the large superfamily of TGF-β/BMP ligands to address thymus morphogenesis and function in T cell diff...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-09-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00442/full |
| _version_ | 1828933634793406464 |
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| author | Arnon Dias Jurberg Arnon Dias Jurberg Larissa eVasconcelos-Fontes Vinicius eCotta-de-Almeida |
| author_facet | Arnon Dias Jurberg Arnon Dias Jurberg Larissa eVasconcelos-Fontes Vinicius eCotta-de-Almeida |
| author_sort | Arnon Dias Jurberg |
| collection | DOAJ |
| description | Multiple signaling pathways control every aspect of cell behavior, organ formation and tissue homeostasis throughout the lifespan of any individual. This review takes an ontogenetic view focused on the large superfamily of TGF-β/BMP ligands to address thymus morphogenesis and function in T cell differentiation. Recent findings on a role of GDF11 for reversing aging-related phenotypes are also discussed. |
| first_indexed | 2024-12-14T01:19:02Z |
| format | Article |
| id | doaj.art-c723cc7f5b874f1c82e707f25a5bec70 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-14T01:19:02Z |
| publishDate | 2015-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-c723cc7f5b874f1c82e707f25a5bec702022-12-21T23:22:30ZengFrontiers Media S.A.Frontiers in Immunology1664-32242015-09-01610.3389/fimmu.2015.00442156812A tale from TGF-β superfamily for thymus ontogeny and functionArnon Dias Jurberg0Arnon Dias Jurberg1Larissa eVasconcelos-Fontes2Vinicius eCotta-de-Almeida3Oswaldo Cruz Institute(IOC)/Oswaldo Cruz Foundation (Fiocruz)Federal University of Rio de Janeiro (UFRJ)Oswaldo Cruz Institute(IOC)/Oswaldo Cruz Foundation (Fiocruz)Oswaldo Cruz Institute(IOC)/Oswaldo Cruz Foundation (Fiocruz)Multiple signaling pathways control every aspect of cell behavior, organ formation and tissue homeostasis throughout the lifespan of any individual. This review takes an ontogenetic view focused on the large superfamily of TGF-β/BMP ligands to address thymus morphogenesis and function in T cell differentiation. Recent findings on a role of GDF11 for reversing aging-related phenotypes are also discussed.http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00442/fullBMPT cell developmentThymusTGF-βThymopoiesis |
| spellingShingle | Arnon Dias Jurberg Arnon Dias Jurberg Larissa eVasconcelos-Fontes Vinicius eCotta-de-Almeida A tale from TGF-β superfamily for thymus ontogeny and function Frontiers in Immunology BMP T cell development Thymus TGF-β Thymopoiesis |
| title | A tale from TGF-β superfamily for thymus ontogeny and function |
| title_full | A tale from TGF-β superfamily for thymus ontogeny and function |
| title_fullStr | A tale from TGF-β superfamily for thymus ontogeny and function |
| title_full_unstemmed | A tale from TGF-β superfamily for thymus ontogeny and function |
| title_short | A tale from TGF-β superfamily for thymus ontogeny and function |
| title_sort | tale from tgf β superfamily for thymus ontogeny and function |
| topic | BMP T cell development Thymus TGF-β Thymopoiesis |
| url | http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00442/full |
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