Napabucasin Reduces Cancer Stem Cell Characteristics in Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer. Cancer stem cells (CSCs) are a rare population with self-renewal and multipotent differentiation capacity, and reside among the more differentiated cancer cells. CSCs are associated with tumor recurrence, drug resistance...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-12-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2020.597520/full |
| _version_ | 1818383873881407488 |
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| author | Ya Li Qiuju Han Huajun Zhao Quanjuan Guo Jian Zhang |
| author_facet | Ya Li Qiuju Han Huajun Zhao Quanjuan Guo Jian Zhang |
| author_sort | Ya Li |
| collection | DOAJ |
| description | Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer. Cancer stem cells (CSCs) are a rare population with self-renewal and multipotent differentiation capacity, and reside among the more differentiated cancer cells. CSCs are associated with tumor recurrence, drug resistance and poor prognosis. The aim of this study was to determine the efficacy of napabucasin against HCC and elucidate the underlying molecular mechanisms. Napabucasin significantly decreased the viability of HCC cells in vitro by inducing apoptosis and cell cycle arrest. In addition, it suppressed CSC-related gene expression and spheroid formation in vitro, indicating depletion of CSCs. The anti-neoplastic effects of napabucasin was also evident in homograft tumor-bearing mouse models. Our findings provide the scientific basis of conducting clinical trials on napabucasin as a new therapeutic agent against HCC. |
| first_indexed | 2024-12-14T03:13:17Z |
| format | Article |
| id | doaj.art-c724bbcb195a412a862d8ffc0c97b851 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-14T03:13:17Z |
| publishDate | 2020-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-c724bbcb195a412a862d8ffc0c97b8512022-12-21T23:19:12ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122020-12-011110.3389/fphar.2020.597520597520Napabucasin Reduces Cancer Stem Cell Characteristics in Hepatocellular CarcinomaYa LiQiuju HanHuajun ZhaoQuanjuan GuoJian ZhangHepatocellular carcinoma (HCC) is the most common type of primary liver cancer. Cancer stem cells (CSCs) are a rare population with self-renewal and multipotent differentiation capacity, and reside among the more differentiated cancer cells. CSCs are associated with tumor recurrence, drug resistance and poor prognosis. The aim of this study was to determine the efficacy of napabucasin against HCC and elucidate the underlying molecular mechanisms. Napabucasin significantly decreased the viability of HCC cells in vitro by inducing apoptosis and cell cycle arrest. In addition, it suppressed CSC-related gene expression and spheroid formation in vitro, indicating depletion of CSCs. The anti-neoplastic effects of napabucasin was also evident in homograft tumor-bearing mouse models. Our findings provide the scientific basis of conducting clinical trials on napabucasin as a new therapeutic agent against HCC.https://www.frontiersin.org/articles/10.3389/fphar.2020.597520/fullnapabucasinstat3hepatocellular carcinomacancer stem cellsstemnesshepatitis B virus |
| spellingShingle | Ya Li Qiuju Han Huajun Zhao Quanjuan Guo Jian Zhang Napabucasin Reduces Cancer Stem Cell Characteristics in Hepatocellular Carcinoma Frontiers in Pharmacology napabucasin stat3 hepatocellular carcinoma cancer stem cells stemness hepatitis B virus |
| title | Napabucasin Reduces Cancer Stem Cell Characteristics in Hepatocellular Carcinoma |
| title_full | Napabucasin Reduces Cancer Stem Cell Characteristics in Hepatocellular Carcinoma |
| title_fullStr | Napabucasin Reduces Cancer Stem Cell Characteristics in Hepatocellular Carcinoma |
| title_full_unstemmed | Napabucasin Reduces Cancer Stem Cell Characteristics in Hepatocellular Carcinoma |
| title_short | Napabucasin Reduces Cancer Stem Cell Characteristics in Hepatocellular Carcinoma |
| title_sort | napabucasin reduces cancer stem cell characteristics in hepatocellular carcinoma |
| topic | napabucasin stat3 hepatocellular carcinoma cancer stem cells stemness hepatitis B virus |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2020.597520/full |
| work_keys_str_mv | AT yali napabucasinreducescancerstemcellcharacteristicsinhepatocellularcarcinoma AT qiujuhan napabucasinreducescancerstemcellcharacteristicsinhepatocellularcarcinoma AT huajunzhao napabucasinreducescancerstemcellcharacteristicsinhepatocellularcarcinoma AT quanjuanguo napabucasinreducescancerstemcellcharacteristicsinhepatocellularcarcinoma AT jianzhang napabucasinreducescancerstemcellcharacteristicsinhepatocellularcarcinoma |