Comparison between the effectiveness of three prophylactic drugs for vestibular migraine; cinnarizine, propranolol, and topiramate: prospective study
Abstract Background Vestibular migraine (VM) is considered one of the most common causes of episodic vertigo. Acute attacks may interfere or hinder daily activities, and hence decrease the quality of life. Accordingly, this study was designed to evaluate and compare the effectiveness of Cinnarizine,...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2023-10-01
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| Series: | The Egyptian Journal of Otolaryngology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43163-023-00518-9 |
| _version_ | 1797454111442993152 |
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| author | Adel Abdel Maksoud Nassar Tamer Hussien Emara Shaimaa Salah Abdel Hamid Eman Mohamed Galal |
| author_facet | Adel Abdel Maksoud Nassar Tamer Hussien Emara Shaimaa Salah Abdel Hamid Eman Mohamed Galal |
| author_sort | Adel Abdel Maksoud Nassar |
| collection | DOAJ |
| description | Abstract Background Vestibular migraine (VM) is considered one of the most common causes of episodic vertigo. Acute attacks may interfere or hinder daily activities, and hence decrease the quality of life. Accordingly, this study was designed to evaluate and compare the effectiveness of Cinnarizine, Propranolol, and Topiramate as prophylactic treatment for vestibular migraine, in order to decrease the occurrence of acute attacks. Several medications have been proposed as a prophylactic treatment, but their benefit is still a vast field of study. Methods Forty-five subjects were diagnosed with vestibular migraine. They were divided into 3 groups; each group either received Cinnarzine, Propranolol, or Topiramate. All patients were submitted to thorough history taking for headache and vertiginous attacks, Dizziness Handicap Inventory questionnaire (DHI) -Arabic version, visual analog scale, videonystagmography, and computerized dynamic posturography (CDP) before and after receiving the treatment by 3 months. Results Topiramate was significantly superior in reducing the frequency and severity of headache attacks. The three drugs showed improvement but with no significant difference as regards duration and frequency of vertiginous attacks, DHI scores, and CDP. Only 5 patients had non-serious temporary side effects. Conclusions The three drugs were effective for ameliorating vertiginous attacks in vestibular migraine patients, but Topiramate was better in the 25 mg twice daily dose. |
| first_indexed | 2024-03-09T15:32:32Z |
| format | Article |
| id | doaj.art-c7254b34524946a1a72c0aefa3040ed9 |
| institution | Directory Open Access Journal |
| issn | 2090-8539 |
| language | English |
| last_indexed | 2024-03-09T15:32:32Z |
| publishDate | 2023-10-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Otolaryngology |
| spelling | doaj.art-c7254b34524946a1a72c0aefa3040ed92023-11-26T12:10:39ZengSpringerOpenThe Egyptian Journal of Otolaryngology2090-85392023-10-013911610.1186/s43163-023-00518-9Comparison between the effectiveness of three prophylactic drugs for vestibular migraine; cinnarizine, propranolol, and topiramate: prospective studyAdel Abdel Maksoud Nassar0Tamer Hussien Emara1Shaimaa Salah Abdel Hamid2Eman Mohamed Galal3Otorhinolaryngology Department, Faculty of Medicine, Ain Shams UniversityNeurology Department, Faculty of Medicine, Ain Shams UniversityOtorhinolaryngology Department, Faculty of Medicine, Ain Shams UniversityOtorhinolaryngology Department, Faculty of Medicine, Ain Shams UniversityAbstract Background Vestibular migraine (VM) is considered one of the most common causes of episodic vertigo. Acute attacks may interfere or hinder daily activities, and hence decrease the quality of life. Accordingly, this study was designed to evaluate and compare the effectiveness of Cinnarizine, Propranolol, and Topiramate as prophylactic treatment for vestibular migraine, in order to decrease the occurrence of acute attacks. Several medications have been proposed as a prophylactic treatment, but their benefit is still a vast field of study. Methods Forty-five subjects were diagnosed with vestibular migraine. They were divided into 3 groups; each group either received Cinnarzine, Propranolol, or Topiramate. All patients were submitted to thorough history taking for headache and vertiginous attacks, Dizziness Handicap Inventory questionnaire (DHI) -Arabic version, visual analog scale, videonystagmography, and computerized dynamic posturography (CDP) before and after receiving the treatment by 3 months. Results Topiramate was significantly superior in reducing the frequency and severity of headache attacks. The three drugs showed improvement but with no significant difference as regards duration and frequency of vertiginous attacks, DHI scores, and CDP. Only 5 patients had non-serious temporary side effects. Conclusions The three drugs were effective for ameliorating vertiginous attacks in vestibular migraine patients, but Topiramate was better in the 25 mg twice daily dose.https://doi.org/10.1186/s43163-023-00518-9Vestibular migraineProphylacticCinnarizinePropranololTopiramate |
| spellingShingle | Adel Abdel Maksoud Nassar Tamer Hussien Emara Shaimaa Salah Abdel Hamid Eman Mohamed Galal Comparison between the effectiveness of three prophylactic drugs for vestibular migraine; cinnarizine, propranolol, and topiramate: prospective study The Egyptian Journal of Otolaryngology Vestibular migraine Prophylactic Cinnarizine Propranolol Topiramate |
| title | Comparison between the effectiveness of three prophylactic drugs for vestibular migraine; cinnarizine, propranolol, and topiramate: prospective study |
| title_full | Comparison between the effectiveness of three prophylactic drugs for vestibular migraine; cinnarizine, propranolol, and topiramate: prospective study |
| title_fullStr | Comparison between the effectiveness of three prophylactic drugs for vestibular migraine; cinnarizine, propranolol, and topiramate: prospective study |
| title_full_unstemmed | Comparison between the effectiveness of three prophylactic drugs for vestibular migraine; cinnarizine, propranolol, and topiramate: prospective study |
| title_short | Comparison between the effectiveness of three prophylactic drugs for vestibular migraine; cinnarizine, propranolol, and topiramate: prospective study |
| title_sort | comparison between the effectiveness of three prophylactic drugs for vestibular migraine cinnarizine propranolol and topiramate prospective study |
| topic | Vestibular migraine Prophylactic Cinnarizine Propranolol Topiramate |
| url | https://doi.org/10.1186/s43163-023-00518-9 |
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