Evaluation of diagnostic performance of serum copeptin in correlation with dyslipidemia in Obesed and Non-Obesed type 2 diabetes mellitus (T2DM)
Background: High fat in the diet is the main explanations for insulin resistance which will cause type 2 DM (T2DM). Obesity has been known to be related to dyslipidemia which may be a metabolic abnormality resulting in a persistent increase within the plasma concentration of cholesterol and triglyce...
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| Format: | Article |
| Language: | English |
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Al Ameen Medical College
2020-10-01
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| Series: | Al Ameen Journal of Medical Sciences |
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| Online Access: | http://ajms.alameenmedical.org/ArticlePDFs/3%20AJMS%20V13.N4.2020%20p%20226-233.pdf |
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| author | Adedeji David Atere Olumide Faith Ajani Oluwaseun Grace Alade Love Adeiye Ajani Adebimpe Iyanuoluwa Moronkeji |
| author_facet | Adedeji David Atere Olumide Faith Ajani Oluwaseun Grace Alade Love Adeiye Ajani Adebimpe Iyanuoluwa Moronkeji |
| author_sort | Adedeji David Atere |
| collection | DOAJ |
| description | Background: High fat in the diet is the main explanations for insulin resistance which will cause type 2 DM (T2DM). Obesity has been known to be related to dyslipidemia which may be a metabolic abnormality resulting in a persistent increase within the plasma concentration of cholesterol and triglycerides. This study thus aimed in determining the diagnostic role of copeptin and its association with dyslipidemia in obesed and non obesed diabetic subjects. Methods: This research was administered on 50 diabetic subjects and 30 age and sex-matched controls. 5ml of blood was collected from each subject and dispensed into an appropriate anticoagulant bottle. Copeptin and atherogenic indices (Total cholesterol, triglycerides, high density lipoprotein, and low density lipoprotein) were determined using standard laboratory techniques. Statistical analysis of the data was done appropriately and P values less than 0.05 were considered significant. Results: The mean values of copeptin, Total Cholesterol, High Density Lipoprotein, and Low Density Lipoprotein were significantly higher in both Obesed and non-obesed diabetic subjects in comparison to the control group (p<0.05). Also, FBS had a higher area under the ROC curve (AUROC) than copeptin. Conclusion: This study shows that diabetic subjects have higher levels of copeptin and atherogenic indices when it's compared with non-diabetic groups. This actually confirmed that copeptin is related to dyslipidemia which is one among an indicator for top risk of atherogenicity, especially in obesed diabetic subjects that had higher copeptin levels than non-obesed diabetes. Also, copeptin wasn't found to be a more accurate marker of diagnosis for DM when its diagnostic performance with fasting blood glucose decided. |
| first_indexed | 2024-12-10T23:54:24Z |
| format | Article |
| id | doaj.art-c727dfd2ff024227921506c519300f42 |
| institution | Directory Open Access Journal |
| issn | 0974-1143 0974-1143 |
| language | English |
| last_indexed | 2024-12-10T23:54:24Z |
| publishDate | 2020-10-01 |
| publisher | Al Ameen Medical College |
| record_format | Article |
| series | Al Ameen Journal of Medical Sciences |
| spelling | doaj.art-c727dfd2ff024227921506c519300f422022-12-22T01:28:39ZengAl Ameen Medical CollegeAl Ameen Journal of Medical Sciences0974-11430974-11432020-10-011304226233Evaluation of diagnostic performance of serum copeptin in correlation with dyslipidemia in Obesed and Non-Obesed type 2 diabetes mellitus (T2DM)Adedeji David Atere0Olumide Faith Ajani1Oluwaseun Grace Alade2Love Adeiye Ajani3Adebimpe Iyanuoluwa Moronkeji4Department of Medical Laboratory Science, Faculty of Basic Medical Sciences, Adeleke University, Ede, Osun State, NigeriaDepartment of Laboratory Logistics, Chemonics International Inc, 11 Anthony Enahoro St, Utako, Abuja, NigeriaDepartment of Medical Laboratory Science, Achievers University, Owo, Ondo State, NigeriaMolecular Laboratory Department, Institute of Human Virology, Abuja, NigeriaDepartment of Medical Laboratory Science, Achievers University, Owo, Ondo State, NigeriaBackground: High fat in the diet is the main explanations for insulin resistance which will cause type 2 DM (T2DM). Obesity has been known to be related to dyslipidemia which may be a metabolic abnormality resulting in a persistent increase within the plasma concentration of cholesterol and triglycerides. This study thus aimed in determining the diagnostic role of copeptin and its association with dyslipidemia in obesed and non obesed diabetic subjects. Methods: This research was administered on 50 diabetic subjects and 30 age and sex-matched controls. 5ml of blood was collected from each subject and dispensed into an appropriate anticoagulant bottle. Copeptin and atherogenic indices (Total cholesterol, triglycerides, high density lipoprotein, and low density lipoprotein) were determined using standard laboratory techniques. Statistical analysis of the data was done appropriately and P values less than 0.05 were considered significant. Results: The mean values of copeptin, Total Cholesterol, High Density Lipoprotein, and Low Density Lipoprotein were significantly higher in both Obesed and non-obesed diabetic subjects in comparison to the control group (p<0.05). Also, FBS had a higher area under the ROC curve (AUROC) than copeptin. Conclusion: This study shows that diabetic subjects have higher levels of copeptin and atherogenic indices when it's compared with non-diabetic groups. This actually confirmed that copeptin is related to dyslipidemia which is one among an indicator for top risk of atherogenicity, especially in obesed diabetic subjects that had higher copeptin levels than non-obesed diabetes. Also, copeptin wasn't found to be a more accurate marker of diagnosis for DM when its diagnostic performance with fasting blood glucose decided.http://ajms.alameenmedical.org/ArticlePDFs/3%20AJMS%20V13.N4.2020%20p%20226-233.pdfatherogenicitycopeptindyslipidemiahyperglycemiaobesity |
| spellingShingle | Adedeji David Atere Olumide Faith Ajani Oluwaseun Grace Alade Love Adeiye Ajani Adebimpe Iyanuoluwa Moronkeji Evaluation of diagnostic performance of serum copeptin in correlation with dyslipidemia in Obesed and Non-Obesed type 2 diabetes mellitus (T2DM) Al Ameen Journal of Medical Sciences atherogenicity copeptin dyslipidemia hyperglycemia obesity |
| title | Evaluation of diagnostic performance of serum copeptin in correlation with dyslipidemia in Obesed and Non-Obesed type 2 diabetes mellitus (T2DM) |
| title_full | Evaluation of diagnostic performance of serum copeptin in correlation with dyslipidemia in Obesed and Non-Obesed type 2 diabetes mellitus (T2DM) |
| title_fullStr | Evaluation of diagnostic performance of serum copeptin in correlation with dyslipidemia in Obesed and Non-Obesed type 2 diabetes mellitus (T2DM) |
| title_full_unstemmed | Evaluation of diagnostic performance of serum copeptin in correlation with dyslipidemia in Obesed and Non-Obesed type 2 diabetes mellitus (T2DM) |
| title_short | Evaluation of diagnostic performance of serum copeptin in correlation with dyslipidemia in Obesed and Non-Obesed type 2 diabetes mellitus (T2DM) |
| title_sort | evaluation of diagnostic performance of serum copeptin in correlation with dyslipidemia in obesed and non obesed type 2 diabetes mellitus t2dm |
| topic | atherogenicity copeptin dyslipidemia hyperglycemia obesity |
| url | http://ajms.alameenmedical.org/ArticlePDFs/3%20AJMS%20V13.N4.2020%20p%20226-233.pdf |
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