Body Fat Changes and Liver Safety in Obese and Overweight Women Supplemented with Conjugated Linoleic Acid: A 12-Week Randomised, Double-Blind, Placebo-Controlled Trial
Preliminary evidence suggests that conjugated linoleic acid (CLA) may reduce body weight and affect body composition. The present study assessed the effect of CLA supplementation on body fat composition in overweight and obese women, while also evaluating the liver safety of CLA use. Seventy-four ob...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-06-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/12/6/1811 |
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| author | Edyta Mądry Ida Judyta Malesza Mehala Subramaniapillai Agata Czochralska-Duszyńska Marek Walkowiak Anna Miśkiewicz-Chotnicka Jarosław Walkowiak Aleksandra Lisowska |
| author_facet | Edyta Mądry Ida Judyta Malesza Mehala Subramaniapillai Agata Czochralska-Duszyńska Marek Walkowiak Anna Miśkiewicz-Chotnicka Jarosław Walkowiak Aleksandra Lisowska |
| author_sort | Edyta Mądry |
| collection | DOAJ |
| description | Preliminary evidence suggests that conjugated linoleic acid (CLA) may reduce body weight and affect body composition. The present study assessed the effect of CLA supplementation on body fat composition in overweight and obese women, while also evaluating the liver safety of CLA use. Seventy-four obese or overweight women were randomly assigned to receive 3 g/day CLA or placebo for 12 weeks. Body composition (dual-energy X-ray absorptiometry) and liver function (<sup>13</sup>C-methacetin breath test and serum liver enzymes) were assessed before and after the trial. Patients receiving CLA experienced a significant reduction of total body fat expressed as mass (<i>p</i> = 0.0007) and percentage (<i>p</i> = 0.0006), android adipose tissue (<i>p</i> = 0.0002), gynoid adipose tissue (<i>p</i> = 0.0028), and visceral adipose tissue (<i>p</i> = 4.2 × 10<sup>−9</sup>) as well as a significant increase in lean body mass to height (<i>p</i> = 6.1 × 10<sup>−11</sup>) when compared to those receiving a placebo. The maximum momentary 13C recovery changes and end-point values were significantly higher in the CLA group when compared to the placebo group (<i>p</i> = 0.0385 and <i>p</i> = 0.0076, respectively). There were no significant changes in alanine aminotransferase, asparagine aminotransferase, and gamma-glutamyl transpeptidase activities between the groups. In conclusion, CLA supplementation was well tolerated and safe for the liver, which shows beneficial effects on fat composition in overweight and obese women. |
| first_indexed | 2024-03-10T19:06:29Z |
| format | Article |
| id | doaj.art-c7283d9b4db8497abac78aa003a2903a |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T19:06:29Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-c7283d9b4db8497abac78aa003a2903a2023-11-20T04:09:22ZengMDPI AGNutrients2072-66432020-06-01126181110.3390/nu12061811Body Fat Changes and Liver Safety in Obese and Overweight Women Supplemented with Conjugated Linoleic Acid: A 12-Week Randomised, Double-Blind, Placebo-Controlled TrialEdyta Mądry0Ida Judyta Malesza1Mehala Subramaniapillai2Agata Czochralska-Duszyńska3Marek Walkowiak4Anna Miśkiewicz-Chotnicka5Jarosław Walkowiak6Aleksandra Lisowska7Department of Physiology, Poznan University of Medical Sciences, 61701 Poznań, PolandDepartment of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, 61701 Poznań, PolandDepartment of Physiology, Poznan University of Medical Sciences, 61701 Poznań, PolandDepartment of Physiology, Poznan University of Medical Sciences, 61701 Poznań, PolandDivision of Reproduction, Department of Gynecology and Obstetrics, Poznan University of Medical Sciences, 61701 Poznań, PolandDepartment of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, 61701 Poznań, PolandDepartment of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, 61701 Poznań, PolandDepartment of Clinical Auxology and Pediatric Nursing, Poznan University of Medical Sciences, 61701 Poznań, PolandPreliminary evidence suggests that conjugated linoleic acid (CLA) may reduce body weight and affect body composition. The present study assessed the effect of CLA supplementation on body fat composition in overweight and obese women, while also evaluating the liver safety of CLA use. Seventy-four obese or overweight women were randomly assigned to receive 3 g/day CLA or placebo for 12 weeks. Body composition (dual-energy X-ray absorptiometry) and liver function (<sup>13</sup>C-methacetin breath test and serum liver enzymes) were assessed before and after the trial. Patients receiving CLA experienced a significant reduction of total body fat expressed as mass (<i>p</i> = 0.0007) and percentage (<i>p</i> = 0.0006), android adipose tissue (<i>p</i> = 0.0002), gynoid adipose tissue (<i>p</i> = 0.0028), and visceral adipose tissue (<i>p</i> = 4.2 × 10<sup>−9</sup>) as well as a significant increase in lean body mass to height (<i>p</i> = 6.1 × 10<sup>−11</sup>) when compared to those receiving a placebo. The maximum momentary 13C recovery changes and end-point values were significantly higher in the CLA group when compared to the placebo group (<i>p</i> = 0.0385 and <i>p</i> = 0.0076, respectively). There were no significant changes in alanine aminotransferase, asparagine aminotransferase, and gamma-glutamyl transpeptidase activities between the groups. In conclusion, CLA supplementation was well tolerated and safe for the liver, which shows beneficial effects on fat composition in overweight and obese women.https://www.mdpi.com/2072-6643/12/6/1811livercytochrome P450<sup>13</sup>C-methacetin breath testobesityadipose tissuebody composition |
| spellingShingle | Edyta Mądry Ida Judyta Malesza Mehala Subramaniapillai Agata Czochralska-Duszyńska Marek Walkowiak Anna Miśkiewicz-Chotnicka Jarosław Walkowiak Aleksandra Lisowska Body Fat Changes and Liver Safety in Obese and Overweight Women Supplemented with Conjugated Linoleic Acid: A 12-Week Randomised, Double-Blind, Placebo-Controlled Trial Nutrients liver cytochrome P450 <sup>13</sup>C-methacetin breath test obesity adipose tissue body composition |
| title | Body Fat Changes and Liver Safety in Obese and Overweight Women Supplemented with Conjugated Linoleic Acid: A 12-Week Randomised, Double-Blind, Placebo-Controlled Trial |
| title_full | Body Fat Changes and Liver Safety in Obese and Overweight Women Supplemented with Conjugated Linoleic Acid: A 12-Week Randomised, Double-Blind, Placebo-Controlled Trial |
| title_fullStr | Body Fat Changes and Liver Safety in Obese and Overweight Women Supplemented with Conjugated Linoleic Acid: A 12-Week Randomised, Double-Blind, Placebo-Controlled Trial |
| title_full_unstemmed | Body Fat Changes and Liver Safety in Obese and Overweight Women Supplemented with Conjugated Linoleic Acid: A 12-Week Randomised, Double-Blind, Placebo-Controlled Trial |
| title_short | Body Fat Changes and Liver Safety in Obese and Overweight Women Supplemented with Conjugated Linoleic Acid: A 12-Week Randomised, Double-Blind, Placebo-Controlled Trial |
| title_sort | body fat changes and liver safety in obese and overweight women supplemented with conjugated linoleic acid a 12 week randomised double blind placebo controlled trial |
| topic | liver cytochrome P450 <sup>13</sup>C-methacetin breath test obesity adipose tissue body composition |
| url | https://www.mdpi.com/2072-6643/12/6/1811 |
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