Characteristics of visual functions and their correlation with OCT-angiography of the macula in patients with small choroidal melanoma
<p> E.B. Myakoshina, S.V. Saakyan </p> <p> Helmholtz National Medical Research Center of Eye Diseases, Moscow, Russian Federation </p> <p> <b>Background</b>: choroidal melanoma is the most common malignancy in ophthalmological practice. However, it is d...
| Main Authors: | , |
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| Format: | Article |
| Language: | Russian |
| Published: |
Prime-Media
2022-11-01
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| Series: | РМЖ "Клиническая офтальмология" |
| Online Access: | http://clinopht.com/upload/iblock/33c/hx6ryv4yc6c9w81cd2xas1k2wh9z3hkp.pdf |
| _version_ | 1826866114047508480 |
|---|---|
| author | Е.Б. Мякошина S.V. Saakyan |
| author_facet | Е.Б. Мякошина S.V. Saakyan |
| author_sort | Е.Б. Мякошина |
| collection | DOAJ |
| description | <p>
E.B. Myakoshina, S.V. Saakyan
</p>
<p>
Helmholtz National Medical Research Center of Eye Diseases, Moscow, Russian Federation
</p>
<p>
<b>Background</b>: choroidal melanoma is the most common malignancy in ophthalmological practice. However, it is difficult to diagnose its early stages, since patients report non-specific symptoms. A delay in malignant tumor diagnosis is associated with metastasis and fatal outcome. Optical coherence tomography angiography (OCT-A) enables to visualize the ocular fundus microcirculation and, as a result, to achieve an earlier diagnosis of choroidal melanoma.
</p>
<p>
<b>Aim</b>: to describe characteristics of the visual functions and their correlation with ophthalmoscopy and OCT-A findings in patients with small choroidal melanoma.
</p>
<p>
<b>Patients and Methods:</b> the study involved 46 (92 eyes) patients with small choroidal melanoma, 17–84 years old (mean 59.67±14.2). All patients were split into 3 groups based on the tumor size. Group 1 (n=17): a prominence is 1.3±0.3 mm and a basal diameter is 6.8±2.2 mm; group 2 (n=12): a prominence is 1.7±0.4 mm and a basal diameter is 8.3±2.01 mm; group 3 (n=17): a prominence is 2.4±0.74 mm and a basal diameter is 9.75±0.47 mm. The control group consisted of healthy paired-eyes (n=46). Visometry with the evaluation of the uncorrected and maximum-corrected distance visual acuity was performed in all patients.
</p>
<p>
<b>Results</b>: a correlation was found between the decrease in the uncorrected and maximum-corrected distance visual acuity and the tumor size (р<005). According to the OCT-A results, an area and perimeter of the foveolar avascular zone expanded with an increase in tumor size (p<0.05). As shown, a decrease in density of the perfusion and vessels in the superficial and deep capillary plexuses in all quadrants of the perifoveolar zone was associated with the tumor growth (p <0.05).
</p>
<p>
<b>Conclusion</b>: the characterization of visual functions and their correlation with ophthalmoscopy is important for identifying the first signs of choroidal melanoma development.The assessment of OCT-A findings is a unique diagnostic criterion enabling to detect the first signs of macular microvascular disorders accompanying the manifestation and growth of extramacular choroidal melanoma. A timely diagnosis of small choroidal melanoma offers the opportunities of adequate treatment and, ultimately, improves the vital prognosis for patients with malignant tumor.
</p>
<p>
<b>Keywords</b>: visual functions, OCT-angiography, maculopathy, small choroidal melanoma.
</p>
<p>
<b>For citation:</b> Myakoshina E.B., Saakyan S.V. Characteristics of visual functions and their correlation with OCT-angiography of the macula in patients with small choroidal melanoma. Russian Journal of Clinical Ophthalmology. 2022;22(4):216–223 (in Russ.). DOI: 10.32364/2311-7729-2022-22-4-216-223.
</p> |
| first_indexed | 2024-03-07T21:40:47Z |
| format | Article |
| id | doaj.art-c72843e327854abc966e9b7c18ee944d |
| institution | Directory Open Access Journal |
| issn | 2311-7729 2619-1571 |
| language | Russian |
| last_indexed | 2025-02-16T21:53:13Z |
| publishDate | 2022-11-01 |
| publisher | Prime-Media |
| record_format | Article |
| series | РМЖ "Клиническая офтальмология" |
| spelling | doaj.art-c72843e327854abc966e9b7c18ee944d2025-01-16T09:39:38ZrusPrime-MediaРМЖ "Клиническая офтальмология"2311-77292619-15712022-11-0122431519Characteristics of visual functions and their correlation with OCT-angiography of the macula in patients with small choroidal melanomaЕ.Б. Мякошина0S.V. Saakyan1Russian Journal of Clinical Ophthalmology, Publisher of «Medicina-Inform» Address for correspondence: Russia, 105064, Moscow, P.O. Box 399Russian Journal of Clinical Ophthalmology, Publisher of «Medicina-Inform» Address for correspondence: Russia, 105064, Moscow, P.O. Box 399<p> E.B. Myakoshina, S.V. Saakyan </p> <p> Helmholtz National Medical Research Center of Eye Diseases, Moscow, Russian Federation </p> <p> <b>Background</b>: choroidal melanoma is the most common malignancy in ophthalmological practice. However, it is difficult to diagnose its early stages, since patients report non-specific symptoms. A delay in malignant tumor diagnosis is associated with metastasis and fatal outcome. Optical coherence tomography angiography (OCT-A) enables to visualize the ocular fundus microcirculation and, as a result, to achieve an earlier diagnosis of choroidal melanoma. </p> <p> <b>Aim</b>: to describe characteristics of the visual functions and their correlation with ophthalmoscopy and OCT-A findings in patients with small choroidal melanoma. </p> <p> <b>Patients and Methods:</b> the study involved 46 (92 eyes) patients with small choroidal melanoma, 17–84 years old (mean 59.67±14.2). All patients were split into 3 groups based on the tumor size. Group 1 (n=17): a prominence is 1.3±0.3 mm and a basal diameter is 6.8±2.2 mm; group 2 (n=12): a prominence is 1.7±0.4 mm and a basal diameter is 8.3±2.01 mm; group 3 (n=17): a prominence is 2.4±0.74 mm and a basal diameter is 9.75±0.47 mm. The control group consisted of healthy paired-eyes (n=46). Visometry with the evaluation of the uncorrected and maximum-corrected distance visual acuity was performed in all patients. </p> <p> <b>Results</b>: a correlation was found between the decrease in the uncorrected and maximum-corrected distance visual acuity and the tumor size (р<005). According to the OCT-A results, an area and perimeter of the foveolar avascular zone expanded with an increase in tumor size (p<0.05). As shown, a decrease in density of the perfusion and vessels in the superficial and deep capillary plexuses in all quadrants of the perifoveolar zone was associated with the tumor growth (p <0.05). </p> <p> <b>Conclusion</b>: the characterization of visual functions and their correlation with ophthalmoscopy is important for identifying the first signs of choroidal melanoma development.The assessment of OCT-A findings is a unique diagnostic criterion enabling to detect the first signs of macular microvascular disorders accompanying the manifestation and growth of extramacular choroidal melanoma. A timely diagnosis of small choroidal melanoma offers the opportunities of adequate treatment and, ultimately, improves the vital prognosis for patients with malignant tumor. </p> <p> <b>Keywords</b>: visual functions, OCT-angiography, maculopathy, small choroidal melanoma. </p> <p> <b>For citation:</b> Myakoshina E.B., Saakyan S.V. Characteristics of visual functions and their correlation with OCT-angiography of the macula in patients with small choroidal melanoma. Russian Journal of Clinical Ophthalmology. 2022;22(4):216–223 (in Russ.). DOI: 10.32364/2311-7729-2022-22-4-216-223. </p>http://clinopht.com/upload/iblock/33c/hx6ryv4yc6c9w81cd2xas1k2wh9z3hkp.pdf |
| spellingShingle | Е.Б. Мякошина S.V. Saakyan Characteristics of visual functions and their correlation with OCT-angiography of the macula in patients with small choroidal melanoma РМЖ "Клиническая офтальмология" |
| title | Characteristics of visual functions and their correlation with OCT-angiography of the macula in patients with small choroidal melanoma |
| title_full | Characteristics of visual functions and their correlation with OCT-angiography of the macula in patients with small choroidal melanoma |
| title_fullStr | Characteristics of visual functions and their correlation with OCT-angiography of the macula in patients with small choroidal melanoma |
| title_full_unstemmed | Characteristics of visual functions and their correlation with OCT-angiography of the macula in patients with small choroidal melanoma |
| title_short | Characteristics of visual functions and their correlation with OCT-angiography of the macula in patients with small choroidal melanoma |
| title_sort | characteristics of visual functions and their correlation with oct angiography of the macula in patients with small choroidal melanoma |
| url | http://clinopht.com/upload/iblock/33c/hx6ryv4yc6c9w81cd2xas1k2wh9z3hkp.pdf |
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