Calcium phosphate: a substitute for aluminum adjuvants?
Introduction: Calcium phosphate was used as an adjuvant in France in diphtheria, tetanus, pertussis and poliomyelitis vaccines. It was later completely substituted by alum salts in the late 80’s, but it still remains as an approved adjuvant for the World Health Organization for human vaccination. Ar...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2017-03-01
|
| Series: | Expert Review of Vaccines |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/14760584.2017.1244484 |
| _version_ | 1797680448944472064 |
|---|---|
| author | Jean-Daniel Masson Michel Thibaudon Laurent Bélec Guillemette Crépeaux |
| author_facet | Jean-Daniel Masson Michel Thibaudon Laurent Bélec Guillemette Crépeaux |
| author_sort | Jean-Daniel Masson |
| collection | DOAJ |
| description | Introduction: Calcium phosphate was used as an adjuvant in France in diphtheria, tetanus, pertussis and poliomyelitis vaccines. It was later completely substituted by alum salts in the late 80’s, but it still remains as an approved adjuvant for the World Health Organization for human vaccination. Area covered: Thus, calcium phosphate is now considered as one of the substances that could replace alum salts in vaccines. The aim of this paper is to draw a review of existing data on calcium phosphate as an adjuvant in order to bring out the strengths and weaknesses for its use on a large scale. Expert commentary: Calcium phosphate is a compound naturally present in the organism, safe and already used in human vaccination. Beyond comparisons with the other adjuvants, calcium phosphate represents a good candidate to replace or to complete alum salts as a vaccine adjuvant. |
| first_indexed | 2024-03-11T23:30:11Z |
| format | Article |
| id | doaj.art-c72914221f1e48e78298ad8eb746ac63 |
| institution | Directory Open Access Journal |
| issn | 1476-0584 1744-8395 |
| language | English |
| last_indexed | 2024-03-11T23:30:11Z |
| publishDate | 2017-03-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Expert Review of Vaccines |
| spelling | doaj.art-c72914221f1e48e78298ad8eb746ac632023-09-20T10:18:01ZengTaylor & Francis GroupExpert Review of Vaccines1476-05841744-83952017-03-0116328929910.1080/14760584.2017.12444841244484Calcium phosphate: a substitute for aluminum adjuvants?Jean-Daniel Masson0Michel Thibaudon1Laurent Bélec2Guillemette Crépeaux3Association E3M (Entraide aux Malades de Myofasciite à Macrophages)de l’Institut PasteurUniversité Paris Descartes, Sorbonne Paris CitéÉcole nationale vétérinaire d’AlfortIntroduction: Calcium phosphate was used as an adjuvant in France in diphtheria, tetanus, pertussis and poliomyelitis vaccines. It was later completely substituted by alum salts in the late 80’s, but it still remains as an approved adjuvant for the World Health Organization for human vaccination. Area covered: Thus, calcium phosphate is now considered as one of the substances that could replace alum salts in vaccines. The aim of this paper is to draw a review of existing data on calcium phosphate as an adjuvant in order to bring out the strengths and weaknesses for its use on a large scale. Expert commentary: Calcium phosphate is a compound naturally present in the organism, safe and already used in human vaccination. Beyond comparisons with the other adjuvants, calcium phosphate represents a good candidate to replace or to complete alum salts as a vaccine adjuvant.http://dx.doi.org/10.1080/14760584.2017.1244484vaccineadjuvantcalcium phosphatesafetyimmune responsealuminum salts |
| spellingShingle | Jean-Daniel Masson Michel Thibaudon Laurent Bélec Guillemette Crépeaux Calcium phosphate: a substitute for aluminum adjuvants? Expert Review of Vaccines vaccine adjuvant calcium phosphate safety immune response aluminum salts |
| title | Calcium phosphate: a substitute for aluminum adjuvants? |
| title_full | Calcium phosphate: a substitute for aluminum adjuvants? |
| title_fullStr | Calcium phosphate: a substitute for aluminum adjuvants? |
| title_full_unstemmed | Calcium phosphate: a substitute for aluminum adjuvants? |
| title_short | Calcium phosphate: a substitute for aluminum adjuvants? |
| title_sort | calcium phosphate a substitute for aluminum adjuvants |
| topic | vaccine adjuvant calcium phosphate safety immune response aluminum salts |
| url | http://dx.doi.org/10.1080/14760584.2017.1244484 |
| work_keys_str_mv | AT jeandanielmasson calciumphosphateasubstituteforaluminumadjuvants AT michelthibaudon calciumphosphateasubstituteforaluminumadjuvants AT laurentbelec calciumphosphateasubstituteforaluminumadjuvants AT guillemettecrepeaux calciumphosphateasubstituteforaluminumadjuvants |