Engineered three-dimensional scaffolds for enhanced bone regeneration in osteonecrosis
Osteonecrosis, which is typically induced by trauma, glucocorticoid abuse, or alcoholism, is one of the most severe diseases in clinical orthopedics. Osteonecrosis often leads to joint destruction, and arthroplasty is eventually required. Enhancement of bone regeneration is a critical management str...
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| Format: | Article |
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KeAi Communications Co., Ltd.
2020-09-01
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| Series: | Bioactive Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X20300682 |
| _version_ | 1797203258271334400 |
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| author | Tongtong Zhu Yutao Cui Mingran Zhang Duoyi Zhao Guangyao Liu Jianxun Ding |
| author_facet | Tongtong Zhu Yutao Cui Mingran Zhang Duoyi Zhao Guangyao Liu Jianxun Ding |
| author_sort | Tongtong Zhu |
| collection | DOAJ |
| description | Osteonecrosis, which is typically induced by trauma, glucocorticoid abuse, or alcoholism, is one of the most severe diseases in clinical orthopedics. Osteonecrosis often leads to joint destruction, and arthroplasty is eventually required. Enhancement of bone regeneration is a critical management strategy employed in osteonecrosis therapy. Bone tissue engineering based on engineered three-dimensional (3D) scaffolds with appropriate architecture and osteoconductive activity, alone or functionalized with bioactive factors, have been developed to enhance bone regeneration in osteonecrosis. In this review, we elaborate on the ideal properties of 3D scaffolds for enhanced bone regeneration in osteonecrosis, including biocompatibility, degradability, porosity, and mechanical performance. In addition, we summarize the development of 3D scaffolds alone or functionalized with bioactive factors for accelerating bone regeneration in osteonecrosis and discuss their prospects for translation to clinical practice. |
| first_indexed | 2024-04-24T08:16:28Z |
| format | Article |
| id | doaj.art-c7299f04a77746a7be4c6fbc09ea5398 |
| institution | Directory Open Access Journal |
| issn | 2452-199X |
| language | English |
| last_indexed | 2024-04-24T08:16:28Z |
| publishDate | 2020-09-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj.art-c7299f04a77746a7be4c6fbc09ea53982024-04-17T03:23:50ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2020-09-0153584601Engineered three-dimensional scaffolds for enhanced bone regeneration in osteonecrosisTongtong Zhu0Yutao Cui1Mingran Zhang2Duoyi Zhao3Guangyao Liu4Jianxun Ding5Department of Orthopedics, China-Japan Union Hospital of Jilin University, 126 Xiantai Street, Changchun, 130033, PR China; Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun, 130022, PR ChinaDepartment of Orthopedics, The Second Hospital of Jilin University, 218 Ziqiang Road, Changchun, 130041, PR ChinaDepartment of Orthopedics, China-Japan Union Hospital of Jilin University, 126 Xiantai Street, Changchun, 130033, PR China; Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun, 130022, PR ChinaKey Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun, 130022, PR ChinaDepartment of Orthopedics, China-Japan Union Hospital of Jilin University, 126 Xiantai Street, Changchun, 130033, PR China; Corresponding author.Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun, 130022, PR ChinaOsteonecrosis, which is typically induced by trauma, glucocorticoid abuse, or alcoholism, is one of the most severe diseases in clinical orthopedics. Osteonecrosis often leads to joint destruction, and arthroplasty is eventually required. Enhancement of bone regeneration is a critical management strategy employed in osteonecrosis therapy. Bone tissue engineering based on engineered three-dimensional (3D) scaffolds with appropriate architecture and osteoconductive activity, alone or functionalized with bioactive factors, have been developed to enhance bone regeneration in osteonecrosis. In this review, we elaborate on the ideal properties of 3D scaffolds for enhanced bone regeneration in osteonecrosis, including biocompatibility, degradability, porosity, and mechanical performance. In addition, we summarize the development of 3D scaffolds alone or functionalized with bioactive factors for accelerating bone regeneration in osteonecrosis and discuss their prospects for translation to clinical practice.http://www.sciencedirect.com/science/article/pii/S2452199X20300682Three-dimensional scaffoldFunctionalizationBone regenerationBone tissue engineeringOsteonecrosis therapy |
| spellingShingle | Tongtong Zhu Yutao Cui Mingran Zhang Duoyi Zhao Guangyao Liu Jianxun Ding Engineered three-dimensional scaffolds for enhanced bone regeneration in osteonecrosis Bioactive Materials Three-dimensional scaffold Functionalization Bone regeneration Bone tissue engineering Osteonecrosis therapy |
| title | Engineered three-dimensional scaffolds for enhanced bone regeneration in osteonecrosis |
| title_full | Engineered three-dimensional scaffolds for enhanced bone regeneration in osteonecrosis |
| title_fullStr | Engineered three-dimensional scaffolds for enhanced bone regeneration in osteonecrosis |
| title_full_unstemmed | Engineered three-dimensional scaffolds for enhanced bone regeneration in osteonecrosis |
| title_short | Engineered three-dimensional scaffolds for enhanced bone regeneration in osteonecrosis |
| title_sort | engineered three dimensional scaffolds for enhanced bone regeneration in osteonecrosis |
| topic | Three-dimensional scaffold Functionalization Bone regeneration Bone tissue engineering Osteonecrosis therapy |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X20300682 |
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