JNK-dependent cell cycle stalling in G2 promotes survival and senescence-like phenotypes in tissue stress

JNK-dependent cell cycle stalling in G2 promotes survival and senescence-like phenotypes in tissue stress

The restoration of homeostasis after tissue damage relies on proper spatial-temporal control of damage-induced apoptosis and compensatory proliferation. In Drosophila imaginal discs these processes are coordinated by the stress response pathway JNK. We demonstrate that JNK signaling induces a dose-d...

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Bibliographic Details
Main Authors: Andrea Cosolo, Janhvi Jaiswal, Gábor Csordás, Isabelle Grass, Mirka Uhlirova, Anne-Kathrin Classen
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-02-01
Series:eLife
Subjects:
G2 arrest
JNK
senescence
tissue damage
non-autonomous overgrowth
injury-induced apoptosis
Online Access:https://elifesciences.org/articles/41036

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