Extrahepatic Drug Transporters in Liver Failure: Focus on Kidney and Gastrointestinal Tract
Emerging information suggests that liver pathological states may affect the expression and function of membrane transporters in the gastrointestinal tract and the kidney. Altered status of the transporters could affect drug as well as endogenous compounds handling with subsequent clinical consequenc...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-08-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/21/16/5737 |
| _version_ | 1797559135848366080 |
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| author | Marek Droździk Stefan Oswald Agnieszka Droździk |
| author_facet | Marek Droździk Stefan Oswald Agnieszka Droździk |
| author_sort | Marek Droździk |
| collection | DOAJ |
| description | Emerging information suggests that liver pathological states may affect the expression and function of membrane transporters in the gastrointestinal tract and the kidney. Altered status of the transporters could affect drug as well as endogenous compounds handling with subsequent clinical consequences. It seems that changes in intestinal and kidney transporter functions provide the compensatory activity of eliminating endogenous compounds (e.g., bile acids) generated and accumulated due to liver dysfunction. A literature search was conducted on the Ovid and PubMed databases to select relevant in vitro, animal and human studies that have reported expression, protein abundance and function of the gastrointestinal and kidney operating ABC (ATP-binding cassette) transporters and SLC (solute carriers) carriers. The accumulated data suggest that liver failure-associated transporter alterations in the gastrointestinal tract and kidney may affect drug pharmacokinetics. The altered status of drug transporters in those organs in liver dysfunction conditions may provide compensatory activity in handling endogenous compounds, affecting local drug actions as well as drug pharmacokinetics. |
| first_indexed | 2024-03-10T17:41:08Z |
| format | Article |
| id | doaj.art-c72a69534f974337904f1582d38f718c |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T17:41:08Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-c72a69534f974337904f1582d38f718c2023-11-20T09:42:08ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-08-012116573710.3390/ijms21165737Extrahepatic Drug Transporters in Liver Failure: Focus on Kidney and Gastrointestinal TractMarek Droździk0Stefan Oswald1Agnieszka Droździk2Department of Pharmacology, Pomeranian Medical University, Powstancow Wlkp 72, 70-111 Szczecin, PolandInstitute of Pharmacology and Toxicology, Rostock University Medical Center, 18051 Rostock, GermanyDepartment of Integrated Dentistry, Pomeranian Medical University, Powstancow Wlkp 72, 70-111 Szczecin, PolandEmerging information suggests that liver pathological states may affect the expression and function of membrane transporters in the gastrointestinal tract and the kidney. Altered status of the transporters could affect drug as well as endogenous compounds handling with subsequent clinical consequences. It seems that changes in intestinal and kidney transporter functions provide the compensatory activity of eliminating endogenous compounds (e.g., bile acids) generated and accumulated due to liver dysfunction. A literature search was conducted on the Ovid and PubMed databases to select relevant in vitro, animal and human studies that have reported expression, protein abundance and function of the gastrointestinal and kidney operating ABC (ATP-binding cassette) transporters and SLC (solute carriers) carriers. The accumulated data suggest that liver failure-associated transporter alterations in the gastrointestinal tract and kidney may affect drug pharmacokinetics. The altered status of drug transporters in those organs in liver dysfunction conditions may provide compensatory activity in handling endogenous compounds, affecting local drug actions as well as drug pharmacokinetics.https://www.mdpi.com/1422-0067/21/16/5737drug transportersliver pathologygastrointestinal tractkidney |
| spellingShingle | Marek Droździk Stefan Oswald Agnieszka Droździk Extrahepatic Drug Transporters in Liver Failure: Focus on Kidney and Gastrointestinal Tract International Journal of Molecular Sciences drug transporters liver pathology gastrointestinal tract kidney |
| title | Extrahepatic Drug Transporters in Liver Failure: Focus on Kidney and Gastrointestinal Tract |
| title_full | Extrahepatic Drug Transporters in Liver Failure: Focus on Kidney and Gastrointestinal Tract |
| title_fullStr | Extrahepatic Drug Transporters in Liver Failure: Focus on Kidney and Gastrointestinal Tract |
| title_full_unstemmed | Extrahepatic Drug Transporters in Liver Failure: Focus on Kidney and Gastrointestinal Tract |
| title_short | Extrahepatic Drug Transporters in Liver Failure: Focus on Kidney and Gastrointestinal Tract |
| title_sort | extrahepatic drug transporters in liver failure focus on kidney and gastrointestinal tract |
| topic | drug transporters liver pathology gastrointestinal tract kidney |
| url | https://www.mdpi.com/1422-0067/21/16/5737 |
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