Achyrocline satureioides (Lam.) DC extracts acting as enzyme modulators: digestion, inflammation, and hemostasis
Achyrocline satureioides is popularly known for its richness in phenolic compounds and medicinal properties (anti-inflammatory, analgesic, and hepatoprotective). The present study aimed at broadening the knowledge about the pharmacological potential exerted by the aqueous and ethanolic extracts of A...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Universidade Estadual de Londrina
2022-02-01
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| Series: | Semina: Ciências Biológicas e da Saúde |
| Subjects: | |
| Online Access: | https://ojs.uel.br/revistas/uel/index.php/seminabio/article/view/43898 |
| _version_ | 1797949079921098752 |
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| author | Mariana Aparecida Braga Tatiane Abreu Marcus Vinicius Trento Pedro Henrique Cesar Tamara Rezende Marques Sérgio Scherrer Thomasi Silvana Marcussi |
| author_facet | Mariana Aparecida Braga Tatiane Abreu Marcus Vinicius Trento Pedro Henrique Cesar Tamara Rezende Marques Sérgio Scherrer Thomasi Silvana Marcussi |
| author_sort | Mariana Aparecida Braga |
| collection | DOAJ |
| description | Achyrocline satureioides is popularly known for its richness in phenolic compounds and medicinal properties (anti-inflammatory, analgesic, and hepatoprotective). The present study aimed at broadening the knowledge about the pharmacological potential exerted by the aqueous and ethanolic extracts of A. satureioides. These extracts were characterized by HPLC and tested for their modulatory action on phospholipases A2 and proteases of snake venoms. In addition, they were tested on the activities of digestive enzymes. Snake venoms were used as tools since they have enzymes with high functional and structural homology to human enzymes. The results demonstrate that the extracts of A. satureioides act as enzymatic inhibitors or potentiators, interfering in processes related to the hemostasis, such as coagulation and thrombus dissolution. In addition, the anti-genotoxic activity and inhibitions exerted on digestive enzymes suggests their potential use in the prevention and/or treatment of several pathologies. New studies could provide information on how the compounds present in the extracts and the different enzymes interact. |
| first_indexed | 2024-04-10T21:53:42Z |
| format | Article |
| id | doaj.art-c72affadc4c34ffbac23820a0f5c746f |
| institution | Directory Open Access Journal |
| issn | 1679-0367 |
| language | English |
| last_indexed | 2024-04-10T21:53:42Z |
| publishDate | 2022-02-01 |
| publisher | Universidade Estadual de Londrina |
| record_format | Article |
| series | Semina: Ciências Biológicas e da Saúde |
| spelling | doaj.art-c72affadc4c34ffbac23820a0f5c746f2023-01-18T10:55:35ZengUniversidade Estadual de LondrinaSemina: Ciências Biológicas e da Saúde1679-03672022-02-0143110111810.5433/1679-0367.2022v43n1p101Achyrocline satureioides (Lam.) DC extracts acting as enzyme modulators: digestion, inflammation, and hemostasisMariana Aparecida Braga0https://orcid.org/0000-0003-0758-3993Tatiane Abreu1https://orcid.org/0000-0002-3809-5442Marcus Vinicius Trento2https://orcid.org/0000-0001-8463-9052Pedro Henrique Cesar3Tamara Rezende Marques4https://orcid.org/0000-0003-3981-2527Sérgio Scherrer Thomasi5https://orcid.org/0000-0001-6493-0723Silvana Marcussi6https://orcid.org/0000-0002-4674-6911Universidade Federal de Lavras - UFLAUniversidade Federal de Lavras - UFLAUniversidade Federal de Lavras - UFLAUniversidade Federal de Lavras - UFLAUniversidade Federal de Lavras - UFLAUniversidade Federal de Lavras - UFLAUniversidade Federal de Lavras - UFLAAchyrocline satureioides is popularly known for its richness in phenolic compounds and medicinal properties (anti-inflammatory, analgesic, and hepatoprotective). The present study aimed at broadening the knowledge about the pharmacological potential exerted by the aqueous and ethanolic extracts of A. satureioides. These extracts were characterized by HPLC and tested for their modulatory action on phospholipases A2 and proteases of snake venoms. In addition, they were tested on the activities of digestive enzymes. Snake venoms were used as tools since they have enzymes with high functional and structural homology to human enzymes. The results demonstrate that the extracts of A. satureioides act as enzymatic inhibitors or potentiators, interfering in processes related to the hemostasis, such as coagulation and thrombus dissolution. In addition, the anti-genotoxic activity and inhibitions exerted on digestive enzymes suggests their potential use in the prevention and/or treatment of several pathologies. New studies could provide information on how the compounds present in the extracts and the different enzymes interact.https://ojs.uel.br/revistas/uel/index.php/seminabio/article/view/43898comet assayproteases inhibitorsphospholipases inhibitorsmedicinal plantstoxins as tools |
| spellingShingle | Mariana Aparecida Braga Tatiane Abreu Marcus Vinicius Trento Pedro Henrique Cesar Tamara Rezende Marques Sérgio Scherrer Thomasi Silvana Marcussi Achyrocline satureioides (Lam.) DC extracts acting as enzyme modulators: digestion, inflammation, and hemostasis Semina: Ciências Biológicas e da Saúde comet assay proteases inhibitors phospholipases inhibitors medicinal plants toxins as tools |
| title | Achyrocline satureioides (Lam.) DC extracts acting as enzyme modulators: digestion, inflammation, and hemostasis |
| title_full | Achyrocline satureioides (Lam.) DC extracts acting as enzyme modulators: digestion, inflammation, and hemostasis |
| title_fullStr | Achyrocline satureioides (Lam.) DC extracts acting as enzyme modulators: digestion, inflammation, and hemostasis |
| title_full_unstemmed | Achyrocline satureioides (Lam.) DC extracts acting as enzyme modulators: digestion, inflammation, and hemostasis |
| title_short | Achyrocline satureioides (Lam.) DC extracts acting as enzyme modulators: digestion, inflammation, and hemostasis |
| title_sort | achyrocline satureioides lam dc extracts acting as enzyme modulators digestion inflammation and hemostasis |
| topic | comet assay proteases inhibitors phospholipases inhibitors medicinal plants toxins as tools |
| url | https://ojs.uel.br/revistas/uel/index.php/seminabio/article/view/43898 |
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