Role of Protein Carbonylation in Skeletal Muscle Mass Loss Associated with Chronic Conditions
Muscle dysfunction, characterized by a reductive remodeling of muscle fibers, is a common systemic manifestation in highly prevalent conditions such as chronic heart failure (CHF), chronic obstructive pulmonary disease (COPD), cancer cachexia, and critically ill patients. Skeletal muscle dysfunction...
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| Format: | Article |
| Language: | English |
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MDPI AG
2016-05-01
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| Series: | Proteomes |
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| Online Access: | http://www.mdpi.com/2227-7382/4/2/18 |
| _version_ | 1798043453674749952 |
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| author | Esther Barreiro |
| author_facet | Esther Barreiro |
| author_sort | Esther Barreiro |
| collection | DOAJ |
| description | Muscle dysfunction, characterized by a reductive remodeling of muscle fibers, is a common systemic manifestation in highly prevalent conditions such as chronic heart failure (CHF), chronic obstructive pulmonary disease (COPD), cancer cachexia, and critically ill patients. Skeletal muscle dysfunction and impaired muscle mass may predict morbidity and mortality in patients with chronic diseases, regardless of the underlying condition. High levels of oxidants may alter function and structure of key cellular molecules such as proteins, DNA, and lipids, leading to cellular injury and death. Protein oxidation including protein carbonylation was demonstrated to modify enzyme activity and DNA binding of transcription factors, while also rendering proteins more prone to proteolytic degradation. Given the relevance of protein oxidation in the pathophysiology of many chronic conditions and their comorbidities, the current review focuses on the analysis of different studies in which the biological and clinical significance of the modifications induced by reactive carbonyls on proteins have been explored so far in skeletal muscles of patients and animal models of chronic conditions such as COPD, disuse muscle atrophy, cancer cachexia, sepsis, and physiological aging. Future research will elucidate the specific impact and sites of reactive carbonyls on muscle protein content and function in human conditions. |
| first_indexed | 2024-04-11T22:49:20Z |
| format | Article |
| id | doaj.art-c72c89bffedc45319e4443c6760d2421 |
| institution | Directory Open Access Journal |
| issn | 2227-7382 |
| language | English |
| last_indexed | 2024-04-11T22:49:20Z |
| publishDate | 2016-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Proteomes |
| spelling | doaj.art-c72c89bffedc45319e4443c6760d24212022-12-22T03:58:38ZengMDPI AGProteomes2227-73822016-05-01421810.3390/proteomes4020018proteomes4020018Role of Protein Carbonylation in Skeletal Muscle Mass Loss Associated with Chronic ConditionsEsther Barreiro0Pulmonology Department and Research Group on Muscle Wasting and Cachexia in Chronic Respiratory Diseases and Lung Cancer, Institut Hospital del Mar d’Investigacions Mèdiques (IMIM)-Hospital del Mar, Health and Experimental Sciences Department (CEXS), Pompeu Fabra University (UPF), Barcelona Biomedical Research Park (PRBB), C/Dr. Aiguader, 88, Barcelona E-08003, SpainMuscle dysfunction, characterized by a reductive remodeling of muscle fibers, is a common systemic manifestation in highly prevalent conditions such as chronic heart failure (CHF), chronic obstructive pulmonary disease (COPD), cancer cachexia, and critically ill patients. Skeletal muscle dysfunction and impaired muscle mass may predict morbidity and mortality in patients with chronic diseases, regardless of the underlying condition. High levels of oxidants may alter function and structure of key cellular molecules such as proteins, DNA, and lipids, leading to cellular injury and death. Protein oxidation including protein carbonylation was demonstrated to modify enzyme activity and DNA binding of transcription factors, while also rendering proteins more prone to proteolytic degradation. Given the relevance of protein oxidation in the pathophysiology of many chronic conditions and their comorbidities, the current review focuses on the analysis of different studies in which the biological and clinical significance of the modifications induced by reactive carbonyls on proteins have been explored so far in skeletal muscles of patients and animal models of chronic conditions such as COPD, disuse muscle atrophy, cancer cachexia, sepsis, and physiological aging. Future research will elucidate the specific impact and sites of reactive carbonyls on muscle protein content and function in human conditions.http://www.mdpi.com/2227-7382/4/2/18oxidantsprotein carbonylationskeletal muscle wasting and dysfunctiondisuse muscle atrophyagingcigarette smokingCOPDcancer-induced cachexiaseptic muscles |
| spellingShingle | Esther Barreiro Role of Protein Carbonylation in Skeletal Muscle Mass Loss Associated with Chronic Conditions Proteomes oxidants protein carbonylation skeletal muscle wasting and dysfunction disuse muscle atrophy aging cigarette smoking COPD cancer-induced cachexia septic muscles |
| title | Role of Protein Carbonylation in Skeletal Muscle Mass Loss Associated with Chronic Conditions |
| title_full | Role of Protein Carbonylation in Skeletal Muscle Mass Loss Associated with Chronic Conditions |
| title_fullStr | Role of Protein Carbonylation in Skeletal Muscle Mass Loss Associated with Chronic Conditions |
| title_full_unstemmed | Role of Protein Carbonylation in Skeletal Muscle Mass Loss Associated with Chronic Conditions |
| title_short | Role of Protein Carbonylation in Skeletal Muscle Mass Loss Associated with Chronic Conditions |
| title_sort | role of protein carbonylation in skeletal muscle mass loss associated with chronic conditions |
| topic | oxidants protein carbonylation skeletal muscle wasting and dysfunction disuse muscle atrophy aging cigarette smoking COPD cancer-induced cachexia septic muscles |
| url | http://www.mdpi.com/2227-7382/4/2/18 |
| work_keys_str_mv | AT estherbarreiro roleofproteincarbonylationinskeletalmusclemasslossassociatedwithchronicconditions |