Human Endogenous Retrovirus, SARS-CoV-2, and HIV Promote PAH via Inflammation and Growth Stimulation
Pulmonary arterial hypertension (PAH) is a pulmonary vascular disease characterized by the progressive elevation of pulmonary arterial pressures. It is becoming increasingly apparent that inflammation contributes to the pathogenesis and progression of PAH. Several viruses are known to cause PAH, suc...
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| Format: | Article |
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MDPI AG
2023-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/8/7472 |
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| author | Desheng Wang Marta T. Gomes Yanfei Mo Clare C. Prohaska Lu Zhang Sarvesh Chelvanambi Matthias A. Clauss Dongfang Zhang Roberto F. Machado Mingqi Gao Yang Bai |
| author_facet | Desheng Wang Marta T. Gomes Yanfei Mo Clare C. Prohaska Lu Zhang Sarvesh Chelvanambi Matthias A. Clauss Dongfang Zhang Roberto F. Machado Mingqi Gao Yang Bai |
| author_sort | Desheng Wang |
| collection | DOAJ |
| description | Pulmonary arterial hypertension (PAH) is a pulmonary vascular disease characterized by the progressive elevation of pulmonary arterial pressures. It is becoming increasingly apparent that inflammation contributes to the pathogenesis and progression of PAH. Several viruses are known to cause PAH, such as severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), human endogenous retrovirus K(HERV-K), and human immunodeficiency virus (HIV), in part due to acute and chronic inflammation. In this review, we discuss the connections between HERV-K, HIV, SARS-CoV-2, and PAH, to stimulate research regarding new therapeutic options and provide new targets for the treatment of the disease. |
| first_indexed | 2024-03-11T04:56:29Z |
| format | Article |
| id | doaj.art-c72ca65734a449cca5cf2dff81420202 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T04:56:29Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-c72ca65734a449cca5cf2dff814202022023-11-17T19:40:57ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-04-01248747210.3390/ijms24087472Human Endogenous Retrovirus, SARS-CoV-2, and HIV Promote PAH via Inflammation and Growth StimulationDesheng Wang0Marta T. Gomes1Yanfei Mo2Clare C. Prohaska3Lu Zhang4Sarvesh Chelvanambi5Matthias A. Clauss6Dongfang Zhang7Roberto F. Machado8Mingqi Gao9Yang Bai10Department of Clinical Pharmacology, School of Pharmacy, China Medical University, Shenyang 110122, ChinaDivision of Pulmonary, Critical Care, Sleep, and Occupational Medicine, Department of Medicine, Indiana University, Indianapolis, IN 46202, USADepartment of Clinical Pharmacology, School of Pharmacy, China Medical University, Shenyang 110122, ChinaDivision of Pulmonary, Critical Care, Sleep, and Occupational Medicine, Department of Medicine, Indiana University, Indianapolis, IN 46202, USADepartment of Clinical Pharmacology, School of Pharmacy, China Medical University, Shenyang 110122, ChinaDivision of Pulmonary, Critical Care, Sleep, and Occupational Medicine, Department of Medicine, Indiana University, Indianapolis, IN 46202, USADivision of Pulmonary, Critical Care, Sleep, and Occupational Medicine, Department of Medicine, Indiana University, Indianapolis, IN 46202, USADepartment of Pharmacognosy, School of Pharmacy, China Medical University, Shenyang 110122, ChinaDivision of Pulmonary, Critical Care, Sleep, and Occupational Medicine, Department of Medicine, Indiana University, Indianapolis, IN 46202, USADepartment of Clinical Pharmacology, School of Pharmacy, China Medical University, Shenyang 110122, ChinaDepartment of Clinical Pharmacology, School of Pharmacy, China Medical University, Shenyang 110122, ChinaPulmonary arterial hypertension (PAH) is a pulmonary vascular disease characterized by the progressive elevation of pulmonary arterial pressures. It is becoming increasingly apparent that inflammation contributes to the pathogenesis and progression of PAH. Several viruses are known to cause PAH, such as severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), human endogenous retrovirus K(HERV-K), and human immunodeficiency virus (HIV), in part due to acute and chronic inflammation. In this review, we discuss the connections between HERV-K, HIV, SARS-CoV-2, and PAH, to stimulate research regarding new therapeutic options and provide new targets for the treatment of the disease.https://www.mdpi.com/1422-0067/24/8/7472human endogenous retrovirus Kpulmonary arterial hypertensionhuman immunodeficiency virusSARS-CoV-2inflammation |
| spellingShingle | Desheng Wang Marta T. Gomes Yanfei Mo Clare C. Prohaska Lu Zhang Sarvesh Chelvanambi Matthias A. Clauss Dongfang Zhang Roberto F. Machado Mingqi Gao Yang Bai Human Endogenous Retrovirus, SARS-CoV-2, and HIV Promote PAH via Inflammation and Growth Stimulation International Journal of Molecular Sciences human endogenous retrovirus K pulmonary arterial hypertension human immunodeficiency virus SARS-CoV-2 inflammation |
| title | Human Endogenous Retrovirus, SARS-CoV-2, and HIV Promote PAH via Inflammation and Growth Stimulation |
| title_full | Human Endogenous Retrovirus, SARS-CoV-2, and HIV Promote PAH via Inflammation and Growth Stimulation |
| title_fullStr | Human Endogenous Retrovirus, SARS-CoV-2, and HIV Promote PAH via Inflammation and Growth Stimulation |
| title_full_unstemmed | Human Endogenous Retrovirus, SARS-CoV-2, and HIV Promote PAH via Inflammation and Growth Stimulation |
| title_short | Human Endogenous Retrovirus, SARS-CoV-2, and HIV Promote PAH via Inflammation and Growth Stimulation |
| title_sort | human endogenous retrovirus sars cov 2 and hiv promote pah via inflammation and growth stimulation |
| topic | human endogenous retrovirus K pulmonary arterial hypertension human immunodeficiency virus SARS-CoV-2 inflammation |
| url | https://www.mdpi.com/1422-0067/24/8/7472 |
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