Restorative biodegradable two-layered hybrid microneedles for melanoma photothermal/chemo co-therapy and wound healing
Abstract Tumor killing and wound healing are two complementary and influential processes during the treatment of melanoma. Herein, a two-layered microneedle platform was developed with bifunctional effect of chemo-photothermal synergistic melanoma therapy and skin regeneration. The bifunctional plat...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-05-01
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| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12951-022-01426-5 |
| _version_ | 1798005434370490368 |
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| author | Yue Shan Bowen Tan Min Zhang Xi Xie Jinfeng Liao |
| author_facet | Yue Shan Bowen Tan Min Zhang Xi Xie Jinfeng Liao |
| author_sort | Yue Shan |
| collection | DOAJ |
| description | Abstract Tumor killing and wound healing are two complementary and influential processes during the treatment of melanoma. Herein, a two-layered microneedle platform was developed with bifunctional effect of chemo-photothermal synergistic melanoma therapy and skin regeneration. The bifunctional platform composed of embeddable curcumin nanodrugs/new Indocyanine Green/hyaluronic acid (Cur NDs/IR820/HA) microneedles and sodium alginate/gelatin/hyaluronic acid (SA/Ge/HA) supporting backing layer was prepared through a two-step casting process. With uniform incorporation of curcumin nanodrugs and IR820, the microneedles exhibited excellent photothermal performance under external near-infrared (NIR) light stimulation and tumor co-therapy ability. Once the embeddable microneedles were inserted into skin, they would rapidly dissolve and activate drug release successfully for tumor treatment. Moreover, the SA/Ge/HA supporting backing layer was left behind to cover the wound and promote the proliferation of endothelial and fibroblasts cells for enhanced skin regeneration. The two-layered microneedles platform can simultaneously eliminate the tumor and accelerate wounding healing, which may be potentially employed as a competitive strategy for the treatment of melanoma. Graphical Abstract |
| first_indexed | 2024-04-11T12:39:10Z |
| format | Article |
| id | doaj.art-c72fd5c01f1f4d4782da7fd47c3093f7 |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-04-11T12:39:10Z |
| publishDate | 2022-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-c72fd5c01f1f4d4782da7fd47c3093f72022-12-22T04:23:33ZengBMCJournal of Nanobiotechnology1477-31552022-05-0120111610.1186/s12951-022-01426-5Restorative biodegradable two-layered hybrid microneedles for melanoma photothermal/chemo co-therapy and wound healingYue Shan0Bowen Tan1Min Zhang2Xi Xie3Jinfeng Liao4State Key Laboratory of Oral Diseases, National Clinical Research Centre for Oral Diseases, West China Hospital of Stomatology, Sichuan UniversityState Key Laboratory of Oral Diseases, National Clinical Research Centre for Oral Diseases, West China Hospital of Stomatology, Sichuan UniversityState Key Laboratory of Oral Diseases, National Clinical Research Centre for Oral Diseases, West China Hospital of Stomatology, Sichuan UniversityState Key Laboratory of Oral Diseases, National Clinical Research Centre for Oral Diseases, West China Hospital of Stomatology, Sichuan UniversityState Key Laboratory of Oral Diseases, National Clinical Research Centre for Oral Diseases, West China Hospital of Stomatology, Sichuan UniversityAbstract Tumor killing and wound healing are two complementary and influential processes during the treatment of melanoma. Herein, a two-layered microneedle platform was developed with bifunctional effect of chemo-photothermal synergistic melanoma therapy and skin regeneration. The bifunctional platform composed of embeddable curcumin nanodrugs/new Indocyanine Green/hyaluronic acid (Cur NDs/IR820/HA) microneedles and sodium alginate/gelatin/hyaluronic acid (SA/Ge/HA) supporting backing layer was prepared through a two-step casting process. With uniform incorporation of curcumin nanodrugs and IR820, the microneedles exhibited excellent photothermal performance under external near-infrared (NIR) light stimulation and tumor co-therapy ability. Once the embeddable microneedles were inserted into skin, they would rapidly dissolve and activate drug release successfully for tumor treatment. Moreover, the SA/Ge/HA supporting backing layer was left behind to cover the wound and promote the proliferation of endothelial and fibroblasts cells for enhanced skin regeneration. The two-layered microneedles platform can simultaneously eliminate the tumor and accelerate wounding healing, which may be potentially employed as a competitive strategy for the treatment of melanoma. Graphical Abstracthttps://doi.org/10.1186/s12951-022-01426-5Two-layered microneedleMelanomaPhotothermal therapySkin regeneration |
| spellingShingle | Yue Shan Bowen Tan Min Zhang Xi Xie Jinfeng Liao Restorative biodegradable two-layered hybrid microneedles for melanoma photothermal/chemo co-therapy and wound healing Journal of Nanobiotechnology Two-layered microneedle Melanoma Photothermal therapy Skin regeneration |
| title | Restorative biodegradable two-layered hybrid microneedles for melanoma photothermal/chemo co-therapy and wound healing |
| title_full | Restorative biodegradable two-layered hybrid microneedles for melanoma photothermal/chemo co-therapy and wound healing |
| title_fullStr | Restorative biodegradable two-layered hybrid microneedles for melanoma photothermal/chemo co-therapy and wound healing |
| title_full_unstemmed | Restorative biodegradable two-layered hybrid microneedles for melanoma photothermal/chemo co-therapy and wound healing |
| title_short | Restorative biodegradable two-layered hybrid microneedles for melanoma photothermal/chemo co-therapy and wound healing |
| title_sort | restorative biodegradable two layered hybrid microneedles for melanoma photothermal chemo co therapy and wound healing |
| topic | Two-layered microneedle Melanoma Photothermal therapy Skin regeneration |
| url | https://doi.org/10.1186/s12951-022-01426-5 |
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