Effects of age and sex on photoperiod modulation of nucleus accumbens monoamine content and release in adolescence and adulthood
Day length, or photoperiod, is a reliable environmental cue encoded by the brain's circadian clock that indicates changing seasons and induces seasonal biological processes. In humans, photoperiod, age, and sex have been linked to seasonality in neuropsychiatric disorders, as seen in Seasonal A...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-05-01
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| Series: | Neurobiology of Sleep and Circadian Rhythms |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2451994424000014 |
| _version_ | 1797235563435130880 |
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| author | Alexis N. Jameson Justin K. Siemann Carrie A. Grueter BradA. Grueter Douglas G. McMahon |
| author_facet | Alexis N. Jameson Justin K. Siemann Carrie A. Grueter BradA. Grueter Douglas G. McMahon |
| author_sort | Alexis N. Jameson |
| collection | DOAJ |
| description | Day length, or photoperiod, is a reliable environmental cue encoded by the brain's circadian clock that indicates changing seasons and induces seasonal biological processes. In humans, photoperiod, age, and sex have been linked to seasonality in neuropsychiatric disorders, as seen in Seasonal Affective Disorder, Major Depressive Disorder, and Bipolar Disorder. The nucleus accumbens is a key locus for the regulation of motivated behaviors and neuropsychiatric disorders. Using periadolescent and young adult male and female mice, here we assessed photoperiod's effect on serotonin and dopamine tissue content in the nucleus accumbens core, as well as on accumbal synaptic dopamine release and uptake. We found greater serotonin and dopamine tissue content in the nucleus accumbens from young adult mice raised in a Short winter-like photoperiod. In addition, dopamine release and clearance were greater in the nucleus accumbens from young adult mice raised in a Long summer-like photoperiod. Importantly, we found that photoperiod's effects on accumbal dopamine tissue content and release were sex-specific to young adult females. These findings support that in mice there are interactions across age, sex, and photoperiod that impact critical monoamine neuromodulators in the nucleus accumbens which may provide mechanistic insight into the age and sex dependencies in seasonality of neuropsychiatric disorders in humans. |
| first_indexed | 2024-04-24T16:49:57Z |
| format | Article |
| id | doaj.art-c73078bb0bf04a5394eca550b288e048 |
| institution | Directory Open Access Journal |
| issn | 2451-9944 |
| language | English |
| last_indexed | 2024-04-24T16:49:57Z |
| publishDate | 2024-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Sleep and Circadian Rhythms |
| spelling | doaj.art-c73078bb0bf04a5394eca550b288e0482024-03-29T05:50:48ZengElsevierNeurobiology of Sleep and Circadian Rhythms2451-99442024-05-0116100103Effects of age and sex on photoperiod modulation of nucleus accumbens monoamine content and release in adolescence and adulthoodAlexis N. Jameson0Justin K. Siemann1Carrie A. Grueter2BradA. Grueter3Douglas G. McMahon4Neuroscience Graduate Program, Vanderbilt University, Nashville, TN, 37232, USAVanderbilt Brain Institute, Vanderbilt University, Nashville, TN, 37232, USA; Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, TN, 37232, USAKennedy Center for Research on Human Development, Vanderbilt University, Nashville, TN, 37232, USA; Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN, 37232, USA; Vanderbilt Center for Addiction Research, Vanderbilt University, Nashville, TN 37232, USA; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, 37232, USA; Department of Pharmacology, Vanderbilt University, Nashville, TN, 37232, USAVanderbilt Brain Institute, Vanderbilt University, Nashville, TN, 37232, USAVanderbilt Brain Institute, Vanderbilt University, Nashville, TN, 37232, USA; Department of Pharmacology, Vanderbilt University, Nashville, TN, 37232, USA; Department of Biological Sciences, Vanderbilt University, Nashville, TN, 37232, USA; Corresponding author. Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, 37232, USA.Day length, or photoperiod, is a reliable environmental cue encoded by the brain's circadian clock that indicates changing seasons and induces seasonal biological processes. In humans, photoperiod, age, and sex have been linked to seasonality in neuropsychiatric disorders, as seen in Seasonal Affective Disorder, Major Depressive Disorder, and Bipolar Disorder. The nucleus accumbens is a key locus for the regulation of motivated behaviors and neuropsychiatric disorders. Using periadolescent and young adult male and female mice, here we assessed photoperiod's effect on serotonin and dopamine tissue content in the nucleus accumbens core, as well as on accumbal synaptic dopamine release and uptake. We found greater serotonin and dopamine tissue content in the nucleus accumbens from young adult mice raised in a Short winter-like photoperiod. In addition, dopamine release and clearance were greater in the nucleus accumbens from young adult mice raised in a Long summer-like photoperiod. Importantly, we found that photoperiod's effects on accumbal dopamine tissue content and release were sex-specific to young adult females. These findings support that in mice there are interactions across age, sex, and photoperiod that impact critical monoamine neuromodulators in the nucleus accumbens which may provide mechanistic insight into the age and sex dependencies in seasonality of neuropsychiatric disorders in humans.http://www.sciencedirect.com/science/article/pii/S2451994424000014PhotoperiodAdolescenceDopamineNucleus accumbensSex differences |
| spellingShingle | Alexis N. Jameson Justin K. Siemann Carrie A. Grueter BradA. Grueter Douglas G. McMahon Effects of age and sex on photoperiod modulation of nucleus accumbens monoamine content and release in adolescence and adulthood Neurobiology of Sleep and Circadian Rhythms Photoperiod Adolescence Dopamine Nucleus accumbens Sex differences |
| title | Effects of age and sex on photoperiod modulation of nucleus accumbens monoamine content and release in adolescence and adulthood |
| title_full | Effects of age and sex on photoperiod modulation of nucleus accumbens monoamine content and release in adolescence and adulthood |
| title_fullStr | Effects of age and sex on photoperiod modulation of nucleus accumbens monoamine content and release in adolescence and adulthood |
| title_full_unstemmed | Effects of age and sex on photoperiod modulation of nucleus accumbens monoamine content and release in adolescence and adulthood |
| title_short | Effects of age and sex on photoperiod modulation of nucleus accumbens monoamine content and release in adolescence and adulthood |
| title_sort | effects of age and sex on photoperiod modulation of nucleus accumbens monoamine content and release in adolescence and adulthood |
| topic | Photoperiod Adolescence Dopamine Nucleus accumbens Sex differences |
| url | http://www.sciencedirect.com/science/article/pii/S2451994424000014 |
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