Sickle Cell Trait Increases Red Blood Cell Storage Hemolysis and Post-Transfusion Clearance in Mice

Sickle Cell Trait Increases Red Blood Cell Storage Hemolysis and Post-Transfusion Clearance in Mice

Background: Transfusion of blood at the limits of approved storage time is associated with lower red blood cell (RBC) post-transfusion recovery and hemolysis, which increases plasma cell-free hemoglobin and iron, proposed to induce endothelial dysfunction and impair host defense. There is noted vari...

Full description

Bibliographic Details
Main Authors: David O. Osei-Hwedieh, PhD, Tamir Kanias, PhD, Claudette St. Croix, PhD, Morgan Jessup, BS, Zeyu Xiong, MD, Derek Sinchar, BS, Jonathan Franks, MS, Qinzi Xu, MD, Enrico M. Novelli, MD, Jonas T. Sertorio, PhD, Karin Potoka, MD, Robert J. Binder, PhD, Swati Basu, PhD, Andrea M. Belanger, PhD, Daniel B. Kim-Shapiro, PhD, Darrell Triulzi, MD, Janet S. Lee, MD, Mark T. Gladwin, MD
Format: Article
Language:English
Published: Elsevier 2016-09-01
Series:EBioMedicine
Subjects:
Sickle cell trait
Red cell storage
Blood
Post-transfusion survival
Transfusion practice
RBC hemolysis
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396416303553

Internet

http://www.sciencedirect.com/science/article/pii/S2352396416303553

Similar Items